Genetic trade-offs in fertility and longevity explain the maintenance of disease-associated alleles in humans
Welter, D. et al. The NHGRI GWAS Catalog, a curated resource of SNP-trait associations. Nucleic Acids Res. 42,…
‘Edited’ human embryos reveal secrets of our development — and fuel ethical debate
A human embryo ‘base edited’ so that it can’t produce a key protein (right), fails to form the…
Whole-genome duplication shaped cell-type evolution in the vertebrate brain
Vertebrate scRNA and snRNA atlas collection, filtering and preprocessing Cell atlases were retrieved from previous publications2,3,4,5. Low-quality cells…
Non-invasive profiling of the tumour microenvironment with spatial ecotypes
Human subjects All human samples included in this study were collected with informed consent for research use and…
Genomic approaches for understanding the evolution of the human brain
Nurk, S. et al. The complete sequence of a human genome. Science 376, 44–53 (2022). Article PubMed PubMed…
Female mice grow testes after this single DNA tweak
Small changes to the non-coding genome can alter whether a mouse embryo (pictured here at 9.5 days old)…
Single-cell spatiotemporal dissection of the human maternal–fetal interface
Tissue acquisition and processing for joint single-nucleus multiome profiling and spatial transcriptomics Snap-frozen decidual and basal plate samples…
How DNA in dirt is shaking up the study of human origins
When he was a doctoral student at the University of Copenhagen, Eske Willerslev was a nobody. At least,…
‘Zombie cells’ return from the dead — after a genome transplant
These Mycoplasma capricolum bacterial cells have absorbed a genome engineered from a closely related bacterium, Mycoplasma mycoides.Credit: Thomas…
No such thing as a shark? Genomes shake up ocean predator’s family tree
This great white shark (Carcharodon carcharias) is still a shark. Credit: Dave Fleetham/Design Pics Editorial/UIG via Getty In…
Genome modelling and design across all domains of life with Evo 2
Nguyen, E. et al. Sequence modeling and design from molecular to genome scale with Evo. Science 386, eado9336…
How DeepMind’s genome AI could help solve rare disease mysteries
Researchers at a Hackathon used AlphaGenome to search for the genetic causes of 29 undiagnosed diseases.Credit: Peter Kováč/Alamy…