Three NHS genetics labs fail to routinely share vital variant data
Three out of England’s seven NHS genetics laboratories are failing to routinely share vital information about genetic variants…
DNA Puts Humans in the Americas at the Height of the Last Ice Age, but the Debate Isn’t Over
Compared to the rest of the world, the American continent welcomed its first humans relatively later. You’d think…
Reference genomes and fossils revise bat family phylogeny and biogeography
Senckenberg-Leibniz Institution for Biodiversity and Earth System Research, Senckenberganlage, Frankfurt, Germany Ariadna E. Morales, Evgeny V. Leushkin, Alexander Ben Hamadou, Alejandro…
New study uncovers bacterial route to testosterone production
Many prostate cancers depend on androgen hormones, including testosterone, to grow. That is why treatments for advanced disease…
Genetic trade-offs in fertility and longevity explain the maintenance of disease-associated alleles in humans
Welter, D. et al. The NHGRI GWAS Catalog, a curated resource of SNP-trait associations. Nucleic Acids Res. 42,…
‘Edited’ human embryos reveal secrets of our development — and fuel ethical debate
A human embryo ‘base edited’ so that it can’t produce a key protein (right), fails to form the…
Whole-genome duplication shaped cell-type evolution in the vertebrate brain
Vertebrate scRNA and snRNA atlas collection, filtering and preprocessing Cell atlases were retrieved from previous publications2,3,4,5. Low-quality cells…
Non-invasive profiling of the tumour microenvironment with spatial ecotypes
Human subjects All human samples included in this study were collected with informed consent for research use and…
Genomic approaches for understanding the evolution of the human brain
Nurk, S. et al. The complete sequence of a human genome. Science 376, 44–53 (2022). Article PubMed PubMed…
Female mice grow testes after this single DNA tweak
Small changes to the non-coding genome can alter whether a mouse embryo (pictured here at 9.5 days old)…
Single-cell spatiotemporal dissection of the human maternal–fetal interface
Tissue acquisition and processing for joint single-nucleus multiome profiling and spatial transcriptomics Snap-frozen decidual and basal plate samples…
How DNA in dirt is shaking up the study of human origins
When he was a doctoral student at the University of Copenhagen, Eske Willerslev was a nobody. At least,…