Language model-guided anticipation and discovery of mammalian metabolites
Training dataset A training dataset of known human metabolites was obtained from the HMDB, the largest and most…
Direct observation of the Migdal effect induced by neutron bombardment
Theory For a gas mixture, the differential cross-section of Migdal effect from neutron–nucleus scattering in the soft limit…
A foundation model for continuous glucose monitoring data
Shilo, S. et al. 10 K: a large-scale prospective longitudinal study in Israel. Eur. J. Epidemiol. 36, 1187–1194…
Disease tolerance and infection pathogenesis age-related tradeoffs in mice
Mice For LD50 and inhibitor experiments, C57BL/6 female mice from Jackson Laboratories (000664) were used. Young mice were…
Ligand-specific activation trajectories dictate GPCR signalling in cells
Biosensor constructionGibson assembly All cloning, except for site-directed mutagenesis, was conducted using Gibson assembly (NEBuilder HiFi DNA Assembly…
3D-printed low-voltage-driven ciliary hydrogel microactuators
Single-layer microelectrodes fabrication Extended Data Fig. 2 illustrates the fabrication process of single-layer microelectrodes. Below are the step-by-step details:…
JWST interferometric imaging reveals the dusty torus obscuring the supermassive black hole of Circinus galaxy
Observations Circinus was observed (ID: 4611; PI: Lopez-Rodriguez, E.) on 20240715 and 20250427 using the Aperture Masking Interferometry…
The ubiquitin ligase KLHL6 drives resistance to CD8+ T cell dysfunction
Mice Male and female mice were used for the study. CD45.1+ OT-I or P14 TCR-transgenic mice were housed…
Global subsidence of river deltas
Selection of global river deltas We selected 40 deltas globally, prioritizing 35 deltaic systems with the greatest exposed…
Dominant contribution of Asgard archaea to eukaryogenesis
Database curation For prokaryotes, 75 million sequences were curated from 47,545 fully sequenced prokaryotic genomes obtained from the NCBI…
An electrically injected solid-state surface acoustic wave phonon laser
Morgan, D. Surface Acoustic Wave Filters: With Applications to Electronic Communications and Signal Processing (Academic Press, 2010). Hashimoto,…
Cancer might evade immune defences by stealing mitochondria
Mitochondria produce energy for the cell, but have a number of other important roles.Credit: Professors P. Motta &…