The blood metabolome of brain health in midlife and influences of genes, microbiome and exposome
Study populationRotterdam Study The Rotterdam Study is a prospective population-based study from the Ommoord district of Rotterdam, The…
Why machine learning fails at mass spectrometry for small molecules
Machine learning approaches are increasingly being used to aid small-molecule structure elucidation from mass spectrometry data. Surprisingly, however,…
Genetic analysis of circulating metabolic traits in 619,372 individuals
Suzuki, K. et al. Genetic drivers of heterogeneity in type 2 diabetes pathophysiology. Nature 627, 347–357 (2024). Article …
Language model-guided anticipation and discovery of mammalian metabolites
Training dataset A training dataset of known human metabolites was obtained from the HMDB, the largest and most…
Neural and molecular changes during a mind-body reconceptualization, meditation, and open label placebo healing intervention
Participant recruitment The study was advertised to all 1444 registered retreat attendees via email invitation, of which 561…
Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD
Cell culture and cell lines The following CRC cell lines were obtained from the American Type Culture Collection…
Genetic architecture of plasma metabolome in 254,825 individuals
Population characteristics We included 254,825 UKB participants with both metabolomic and genomic data available after quality control. The…
MSnLib: efficient generation of open multi-stage fragmentation mass spectral libraries
Materials All solvents used were of LC–MS grade. Methanol, acetonitrile, water and formic acid were obtained from Thermo…