Prion-like transmission of human tau strains in the mouse brain
Peng, C., Trojanowski, J. Q. & Lee, V. M.-Y. Protein transmission in neurodegenerative disease. Nat. Rev. Neurol. 16,…
mTORC1 drives cell-autonomous astrocyte reactivity in tuberous sclerosis
hPS cell culture Derivation, maintenance and differentiation of human pluripotent stem cell lines was approved by the University…
A global molecular code for birth order and neuronal identity in Drosophila
scRNA-seq data generation To discriminate technical from biological variability, we used flies from different genetic backgrounds19,77, enabling us…
Cell-type signatures of Alzheimer’s disease shared across population groups
Study participants, ethics and clinicopathological characterization All brain tissue was obtained from participants in the Religious Order Study…
Hyperglycosylation is a metabolic driver of Alzheimer’s disease
Hyperglycosylation in human AD specimens Recent advances include a multiplexed matrix-assisted laser desorption ionization (MALDI)–mass spectrometry imaging (MSI)…
Astrocyte glucocorticoid receptor signalling restricts neuronal plasticity
Animals Animal care and surgical procedures were approved and overseen by the Harvard University Institutional Animal Care and…
Agouti integrates environmental cues to regulate paternal behaviour
Animals All experiments were conducted in accordance with the guidelines of the Institutional Animal Care and Use Committee…
Pyramidal neurons proportionately alter cortical interneuron subtypes
Yoshimura, Y. & Callaway, E. M. Fine-scale specificity of cortical networks depends on inhibitory cell type and connectivity.…
Thalamocortical transcriptional gates coordinate memory stabilization
Yadav, N., Toader, A. & Rajasethupathy, P. Beyond hippocampus: thalamic and prefrontal contributions to an evolving memory. Neuron…
CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes
Animals All mice were maintained according to the National Institutes of Health guidelines and all procedures used in…