Disease tolerance and infection pathogenesis age-related tradeoffs in mice
Mice For LD50 and inhibitor experiments, C57BL/6 female mice from Jackson Laboratories (000664) were used. Young mice were…
Ligand-specific activation trajectories dictate GPCR signalling in cells
Biosensor constructionGibson assembly All cloning, except for site-directed mutagenesis, was conducted using Gibson assembly (NEBuilder HiFi DNA Assembly…
3D-printed low-voltage-driven ciliary hydrogel microactuators
Single-layer microelectrodes fabrication Extended Data Fig. 2 illustrates the fabrication process of single-layer microelectrodes. Below are the step-by-step details:…
JWST interferometric imaging reveals the dusty torus obscuring the supermassive black hole of Circinus galaxy
Observations Circinus was observed (ID: 4611; PI: Lopez-Rodriguez, E.) on 20240715 and 20250427 using the Aperture Masking Interferometry…
The ubiquitin ligase KLHL6 drives resistance to CD8+ T cell dysfunction
Mice Male and female mice were used for the study. CD45.1+ OT-I or P14 TCR-transgenic mice were housed…
Global subsidence of river deltas
Selection of global river deltas We selected 40 deltas globally, prioritizing 35 deltaic systems with the greatest exposed…
Dominant contribution of Asgard archaea to eukaryogenesis
Database curation For prokaryotes, 75 million sequences were curated from 47,545 fully sequenced prokaryotic genomes obtained from the NCBI…
An electrically injected solid-state surface acoustic wave phonon laser
Morgan, D. Surface Acoustic Wave Filters: With Applications to Electronic Communications and Signal Processing (Academic Press, 2010). Hashimoto,…
Cancer might evade immune defences by stealing mitochondria
Mitochondria produce energy for the cell, but have a number of other important roles.Credit: Professors P. Motta &…
Trapping of single atoms in metasurface optical tweezer arrays
Kaufman, A. M. & Ni, K.-K. Quantum science with optical tweezer arrays of ultracold atoms and molecules. Nat.…
Little red dots as young supermassive black holes in dense ionized cocoons
Greene, J. E. et al. UNCOVER spectroscopy confirms the surprising ubiquity of active galactic nuclei in red sources…
why some people die from typically harmless germs
Michael Levin had just started working as a paediatric infectious-disease doctor in London when he received an urgent…