Performance and safety of a multi-cancer early detection test: the PATHFINDER 2 study
Ethical approval and consent This study was performed in accordance with the Declaration of Helsinki. All study procedures…
Psilocybin-assisted therapy for treatment-resistant major depressive disorder in a public healthcare setting: a randomized controlled trial
This study of psilocybin assisted-therapy for TRD—to our knowledge, the first RCT in this population to assess feasibility…
Health system learning enables generalist neuroimaging models
Health system learning We define ‘health system learning’ as learning directly from uncurated data generated during routine clinical…
Prevalence and severity of mental health problems in early-career researchers: a systematic review and meta-analysis
Evans, T. M., Bira, L., Gastelum, J. B., Weiss, L. T. & Vanderford, N. L. Evidence for a…
Generative AI-enabled clinical decision support system in primary care: a pragmatic, cluster-randomized trial
Design We conducted a pragmatic, multicenter, parallel-group cluster-randomized controlled trial across a network of 16 primary care facilities…
Evaluating the robustness and readiness of large frontier models in health AI applications
Singhal, K. et al. Large language models encode clinical knowledge. Nature 620, 172–180 (2023). Article CAS PubMed PubMed…
Apitegromab for lean mass preservation during tirzepatide-induced weight loss: a randomized, double-blind, placebo-controlled phase 2 trial
Trial details EMBRAZE was a randomized, double-blind, placebo-controlled, phase 2 trial (NCT06445075) conducted at seven sites in the…
A reporting checklist for large language models in behavioural science
LMU Munich, Munich, Germany Stefan Feuerriegel, Kerstin Forster, Dominique Geissler, Abdurahman Maarouf, Sebastian Maier & Barbara Plank Munich Center for Machine Learning, Munich, Germany…
A systematic overview and second-order meta-analysis of nature-based interventions for stress, anxiety and depression
McGrath, J. J. et al. Age of onset and cumulative risk of mental disorders: a cross-national analysis of…
MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial
Study conduct The trial was conducted from 19 May 2022 to 2 March 2026 (data cutoff date) in…
The healing power of nature reduces stress, anxiety and depression
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This…
Advancing conversational diagnostic AI with multimodal reasoning
This work advances the diagnostic capabilities of the multimodal AMIE system4,5 by integrating multimodal perception, enabling it to…