Ageing promotes metastasis via activation of the integrated stress response
Mice and in vivo studies KrasLSL-G12D/+Trp53flox/flox mice (designated as KP)60 were maintained on a mixed C57BL/6-129/Sv genetic background.…
Fecal microbiota transplantation plus immunotherapy in non-small cell lung cancer and melanoma: the phase 2 FMT-LUMINate trial
Study participants and clinical trial design The FMT-LUMINate trial (NCT04951583) is a multicenter, open-label, phase 2 trial that…
Machine learning models can predict urgent care eeds for patients with non–small cell lung cancer
A new study published in JCO Clinical Cancer Informatics demonstrates that machine learning models incorporating patient-reported outcomes and…
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours
DeNardo, D. G. & Ruffell, B. Macrophages as regulators of tumour immunity and immunotherapy. Nat. Rev. Immunol. 19,…
AI Model Finds Gene Targets and Drug Combos to Reprogram Diseased Cells
Credit: FlashMovie/Getty Images Traditional drug discovery has often followed the “one drug, one target” paradigm—developing compounds against individual…
Tracing the evolution of single-cell 3D genomes in Kras-driven cancers
Ethics Statement All animal studies were approved by the Institutional Animal Care and Use Committee of Yale University.…