De novo design of cysteine proteases
Radzicka, A. & Wolfenden, R. Rates of uncatalyzed peptide bond hydrolysis in neutral solution and the transition state…
AI-redesigned starting points and outcomes enhance protein evolution
General methods Antibiotics from Gold Biotechnology were prepared in 1,000× stock solutions in water unless otherwise indicated: chloramphenicol…
De novo design of quasisymmetric two-component protein cages
Caspar, D. L. D. & Klug, A. Physical principles in the construction of regular viruses. Cold Spring Harb.…
Engineered prime editors with minimal genomic errors
Mammalian cell culture All mammalian cell cultures were maintained in a 37 °C incubator at 5% CO2. HEK293T human…
Introducing Latent-X, a Frontier Generative AI Model for Protein Binder Design Accessible via No-Code Platform for Push-Button Protein Design
Latent-X generates lab-ready macrocycles and protein mini-binders at all-atom resolution to accelerate drug design The model can be…