Distinct genetic architecture in the tails of complex traits
Data processingUKB genotype data The UKB is a prospective cohort study of approximately 500,000 participants recruited across the…
Hotspots of human mutation point to clonal expansions in spermatogonia
Lawson, A. R. J. et al. Somatic mutation and selection at population scale. Nature https://doi.org/10.1038/s41586-025-09584-w (2025). Maeda, H.…
Sperm sequencing reveals extensive positive selection in the male germline
Ethics This study was carried out under TwinsUK BioBank ethics, approved by the North West–Liverpool Central Research Ethics…
Whole-genome sequencing of 490,640 UK Biobank participants
We integrated deep phenotyping data27 available for most UKB participants and performed genetic association analysis across selected disease…