Why machine learning fails at mass spectrometry for small molecules
Machine learning approaches are increasingly being used to aid small-molecule structure elucidation from mass spectrometry data. Surprisingly, however,…
Distinct genetic architecture in the tails of complex traits
Data processingUKB genotype data The UKB is a prospective cohort study of approximately 500,000 participants recruited across the…
Towards improved fine-mapping of candidate causal variants
Visscher, P. M. et al. 10 years of GWAS discovery: biology, function, and translation. Am. J. Hum. Genet.…
Mapping trait-associated cells with spatial transcriptomics
Genome-wide association studies (GWAS) have uncovered numerous genetic variants associated with complex traits. However, a critical gap remains…