A data-driven framework reconstructs the molecular continuum of human MASLD progression
Transcriptomics-based disease trajectory analysis captures MASLD progression We first sought to determine whether MASLD progression could be represented…
The blood metabolome of brain health in midlife and influences of genes, microbiome and exposome
Study populationRotterdam Study The Rotterdam Study is a prospective population-based study from the Ommoord district of Rotterdam, The…
A deep-learning framework reveals whole-body perturbations at cell level
Animals Male Uchl1-eGFP and Cd68-eGFP mice (aged 8 weeks) on the C57BL/6J background or wild-type C57BL/6J mice were fed either a…
Single-cell spatial transcriptomic analysis of human skin anatomy
A single-cell spatial MERFISH atlas of normal human skin To map the cellular and spatial diversity of human…