Single-cell spatial transcriptomic analysis of human skin anatomy
A single-cell spatial MERFISH atlas of normal human skin To map the cellular and spatial diversity of human…
Youthful antics predict lifespan — at least for these fish
You snooze, you lose: young killifish (Nothobranchius furzeri) that take daytime naps have relatively short lives. Credit: Andrew…
A ‘time capsule for cells’ stores the secret experiences of their past
Ribosomes, pictured here, synthesize proteins by translating messenger RNA (mRNA) into amino acid chains. Credit: Christoph Burgstedt/Science Photo…
Multimodal learning enables chat-based exploration of single-cell data
Multimodal training data of paired transcriptomes and text To establish a large training dataset of transcriptomes and their…
Multi-omic profiling reveals age-related immune dynamics in healthy adults
The Sound Life study cohort Healthy 25- to 35-year-old and 55- to 65-year-old adult donors were prospectively recruited from the greater Seattle,…
Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq
Constructing the scTF-seq library and single-cell atlas To establish scTF-seq, we built a dox-inducible lentiviral open reading frame…
Genetic variants affecting RNA stability influence complex traits and disease risk
Ethics This research study did not require approval from any specific ethics board/committee. CNV removal We obtained absolute…
Personalized Medicine (Biologics, Small Molecules, Gene
Dublin, Sept. 08, 2025 (GLOBE NEWSWIRE) — The “Personalized Medicine: Market Share, and Growth Analysis by Product Type…
A multi-tissue single-cell expression atlas in cattle
The scope of CattleCA After removing low-quality cells and doublets (Methods, Supplementary Fig. 1 and Supplementary Tables 1…
Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states
Regev, A. et al. The human cell atlas. eLife 6, e27041 (2017). PubMed PubMed Central Google Scholar Karlsson,…
Analysis of individual patient pathway coordination in a cross-species single-cell kidney atlas
GBD Chronic Kidney Disease Collaboration Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis…
Methods and applications of in vivo CRISPR screening
Auton, A. et al. A global reference for human genetic variation. Nature 526, 68–74 (2015). Google Scholar GarcÃa-GarcÃa,…