Homologous recombination deficiency and hemizygosity drive resistance in breast cancer
Study cohort and prospective sequencing The study cohort comprised 6,927 tumour samples from 5,881 patients with breast cancer.…
Meta-analysis reveals differences in somatic alterations by genetic ancestry across common cancers
Genetic ancestry is a quantitative measure of inherited genetic variation and correlates with human migration patterns1. It contributes…
Tracing the evolution of single-cell 3D genomes in Kras-driven cancers
Ethics Statement All animal studies were approved by the Institutional Animal Care and Use Committee of Yale University.…