Thymulin restrains age-associated myeloid inflammation and enhances cancer immunotherapy
Ethics statement All animal experiments were performed in accordance with and approved by the Institutional Animal Care and…
Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC
Trial design and data reporting The primary objective of this open-label, first-in-human, phase 1, three-arm umbrella trial (ClinicalTrials.gov:…
The ubiquitin ligase KLHL6 drives resistance to CD8+ T cell dysfunction
Mice Male and female mice were used for the study. CD45.1+ OT-I or P14 TCR-transgenic mice were housed…
Proteotoxic stress response drives T cell exhaustion and immune evasion
Cell lines The MC38 cell line was purchased from Kerafast (ENH204-FP). The MB49 cell line was purchased from…
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours
DeNardo, D. G. & Ruffell, B. Macrophages as regulators of tumour immunity and immunotherapy. Nat. Rev. Immunol. 19,…
Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy
Clinical samples and cohorts Supplementary Table 10 summarizes the different clinical cohorts used in this Article, and presents…