{"id":102521,"date":"2025-08-22T19:27:09","date_gmt":"2025-08-22T19:27:09","guid":{"rendered":"https:\/\/www.newsbeep.com\/us\/102521\/"},"modified":"2025-08-22T19:27:09","modified_gmt":"2025-08-22T19:27:09","slug":"growth-hormone-benefits-kids-with-rare-genetic-condition","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/us\/102521\/","title":{"rendered":"Growth Hormone Benefits Kids With Rare Genetic Condition"},"content":{"rendered":"

TOPLINE:<\/p>\n

A standard-dose recombinant growth hormone therapy administered for 2 years demonstrated positive effects on both growth and nutritional status in prepubertal children with Silver-Russell syndrome<\/a>, a condition characterized by severe growth retardation and feeding difficulties. Initiating treatment before the age of 4 years optimized height gains in these patients.<\/p>\n

METHODOLOGY:About 90% of children with Silver-Russell syndrome have severe feeding difficulties, primarily before the age of 6 years, and nearly 70% are malnourished. Data on the effects of recombinant growth hormone, especially during the initial years of therapy, are limited.To address this gap, researchers conducted a retrospective single-center analysis of 77 children (including 36 girls) with no sign of puberty and molecularly confirmed Silver-Russell syndrome who initiated growth hormone therapy at a mean age of 3.7 years.A clinical file, including extensive clinical, radiological, and biological data; growth charts; and a detailed phenotypic description, was completed for all children; these data were retrospectively collected at the initiation of treatment, 1 year before treatment, and 1-2 years after treatment onset.Changes in height standard deviation score (SDS) and ideal weight-for-height (as a proxy for nutritional status) were tracked.TAKEAWAY:Children showed a significant improvement in height, gaining 0.8 SDS after 1 year and 1.3 SDS after 2 years of treatment, with most (71.4%) achieving normal height (greater than -2 SDS); girls had greater gains in both height and BMI than boys (P < .05 for both).After 2 years of treatment, children who started growth hormone therapy before the age of 4 years (n = 46) achieved greater height gains than those who started therapy later (1.5 vs 1.1 SDS; P = .012).The ideal weight-for-height increased from a median of 80% at the initiation of therapy to 84% after 1 year and 86% after 2 years (P < .001 for both).The proportion of children with weight-for-height less than 75% declined after 2 years of therapy, whereas those surpassing the 85% target increased.IN PRACTICE:<\/p>\n

\u201cThe nutritional status is crucial for these children, especially during the early years of life, as there is a high risk of hypoglycemia; therefore, nutritional interventions, such as early oral feeding therapy, nutritional enrichment, and cyproheptadine for those who are severely undernourished is essential,\u201d the authors of the study wrote.<\/p>\n

\u201cWe show here that rGH [recombinant growth hormone] also plays a part in the nutritional intervention,\u201d they added.<\/p>\n

SOURCE:<\/p>\n

This study was led by Elo\u00efse Giabicani and Rapha\u00eblle Billette de Villemeur of the H\u00f4pital Armand Trousseau in Paris, France. It was published online<\/a> on August 19, 2025, in The Journal of Clinical Endocrinology & Metabolism.<\/p>\n

LIMITATIONS:<\/p>\n

This study did not discuss any limitations.<\/p>\n

DISCLOSURES:<\/p>\n

This study received funding from the Rare Disorders Reference Centre (CRESCENDO). The authors reported having no conflicts of interest.<\/p>\n

This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.<\/p>\n","protected":false},"excerpt":{"rendered":"TOPLINE: A standard-dose recombinant growth hormone therapy administered for 2 years demonstrated positive effects on both growth and…\n","protected":false},"author":2,"featured_media":102522,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[50],"tags":[182,181,1879,32899,36727,13097,22015,151,1875,46618,200,25984,68427,68426,68428,67692,8284,1877,1878,1876,9778,79,68429],"class_list":["post-102521","post","type-post","status-publish","format-standard","has-post-thumbnail","category-genetics","tag-ai","tag-artificial-intelligence","tag-artificial-neural-networks","tag-bmi","tag-body-mass-index","tag-child","tag-childhood","tag-children","tag-deep-learning","tag-endocrinology","tag-genetics","tag-genomics-genomic-medicine","tag-growth-hormone","tag-growth-hormone-deficiency-gh-deficiency-growth-hormone-deficiency-ghd","tag-hormonal-therapy","tag-hormone-therapy","tag-kids","tag-machine-learning","tag-ml-natural-language-processing","tag-npl","tag-pediatrics","tag-science","tag-silver-russell-syndrome"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/102521","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/comments?post=102521"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/102521\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media\/102522"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media?parent=102521"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/categories?post=102521"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/tags?post=102521"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}