{"id":106909,"date":"2025-08-24T16:12:19","date_gmt":"2025-08-24T16:12:19","guid":{"rendered":"https:\/\/www.newsbeep.com\/us\/106909\/"},"modified":"2025-08-24T16:12:19","modified_gmt":"2025-08-24T16:12:19","slug":"bacteria-strains-infecting-cattle-and-humans-in-us-are-highly-similar","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/us\/106909\/","title":{"rendered":"Bacteria strains infecting cattle and humans in US are highly similar"},"content":{"rendered":"<p>Using the publicly available date, the team looked for genetic components associated with enhanced pathogenicity, such as virulence \u2014 the severity or harmfulness of a disease \u2014 and antimicrobial resistance. They found that bovine strains \u2014 from cattle \u2014 had the highest prevalence of certain antimicrobial resistance genes, a higher prevalence of a small section of circular genetic material separate from the main genome called a plasmid with multidrug resistance and the greatest genetic diversity, indicating more variation among cattle strains. Despite some genetic differences depending on the strain source, the genetic components \u2014 called the genomic core \u2014 shared across all 2,150 strains, was highly similar regardless of source, the researchers said.<\/p>\n<p>\u201cHumans usually get infected by eating contaminated beef, milk or cheese, but direct contact with cattle by farm workers, for example, is also a risk,\u201d Ganda said. \u201cThis study shows that to tackle antibiotic-resistant Salmonella Dublin, we must use a One Health approach \u2014 looking at how humans, animals and the environment are interconnected in the spread and evolution of this dangerous pathogen.\u201d<\/p>\n<p>This study took a different approach to Salmonella Dublin than past research, noted study first author <a href=\"https:\/\/animalscience.psu.edu\/directory\/smk459\" rel=\"nofollow noopener\" target=\"_blank\">Sophia Kenney<\/a>, postdoctoral scholar in the Department of Animal Science.<\/p>\n<p>\u201cMany past studies looked at specific sources such as only cattle, regions or time periods, but this study used all publicly available U.S. whole-genome sequenced strains from human, cattle and environmental strains,\u201d she said. \u201cWe wanted to get at the potential One Health dynamics of this pathogen in the U.S., a major beef and dairy producing country, by examining genomic differences and stability across strains from the different yet related sources and over time.\u201d<\/p>\n<p>The evolution of some Salmonella\u00a0Dublin toward increased multidrug resistance is a concern and definitely something to keep an eye on, Kenney noted.<\/p>\n<p>\u201cIt complicates treatment for both cattle and humans, but knowing the genetic trends of Salmonella Dublin across multiple sources in the U.S. can better inform disease control and more targeted surveillance efforts,\u201d she said.<\/p>\n<p>Nkuchia M\u2019ikanatha, lead epidemiologist for the Pennsylvania Department of Health and an affiliated researcher in Penn State\u2019s Department of Food Science, contributed to this study.<\/p>\n<p>This research was supported, in part, by the U.S. Department of Agriculture\u2019s National Institute of Food and Agriculture, and the U.S. Department of Agriculture Animal and Plant Health Inspection Service National Bio and Agro-Defense Facility Scientist Training Program.<\/p>\n","protected":false},"excerpt":{"rendered":"Using the publicly available date, the team looked for genetic components associated with enhanced pathogenicity, such as virulence&hellip;\n","protected":false},"author":2,"featured_media":106910,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[50],"tags":[200,79],"class_list":["post-106909","post","type-post","status-publish","format-standard","has-post-thumbnail","category-genetics","tag-genetics","tag-science"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/106909","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/comments?post=106909"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/106909\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media\/106910"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media?parent=106909"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/categories?post=106909"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/tags?post=106909"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}