{"id":10814,"date":"2025-07-15T04:57:04","date_gmt":"2025-07-15T04:57:04","guid":{"rendered":"https:\/\/www.newsbeep.com\/us\/10814\/"},"modified":"2025-07-15T04:57:04","modified_gmt":"2025-07-15T04:57:04","slug":"altered-transcription-in-dup15q-syndrome-and-more","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/us\/10814\/","title":{"rendered":"Altered transcription in dup15q syndrome; and more"},"content":{"rendered":"<p>Connecting threads: Transcriptional changes seen in cortical organoids derived from people with dup15q syndrome are consistent with those detected in postmortem brain samples, according to a new study. Affected processes included increased glycolysis, disrupted marker expression and aberrant morphology. Previous work by this research group found <a href=\"https:\/\/www.thetransmitter.org\/spectrum\/consistent-convergent-pathways-link-two-forms-of-autism\/\" rel=\"nofollow noopener\" target=\"_blank\">parallels between dup15q syndrome and idiopathic autism<\/a>. The investigators theorize that the observed metabolic dysregulation \u201cmay lead to altered neuron projection, synaptic dysfunction, and neuron hyperexcitability in dup15q syndrome.\u201d <a href=\"https:\/\/doi.org\/10.1038\/s41467-025-61184-4\" target=\"_blank\" rel=\"nofollow noopener\">Nature Communications<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"Connecting threads: Transcriptional changes seen in cortical organoids derived from people with dup15q syndrome are consistent with those&hellip;\n","protected":false},"author":2,"featured_media":10815,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[50],"tags":[200,79],"class_list":["post-10814","post","type-post","status-publish","format-standard","has-post-thumbnail","category-genetics","tag-genetics","tag-science"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/10814","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/comments?post=10814"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/10814\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media\/10815"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media?parent=10814"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/categories?post=10814"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/tags?post=10814"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}