{"id":214672,"date":"2025-10-10T16:23:09","date_gmt":"2025-10-10T16:23:09","guid":{"rendered":"https:\/\/www.newsbeep.com\/us\/214672\/"},"modified":"2025-10-10T16:23:09","modified_gmt":"2025-10-10T16:23:09","slug":"genes-have-harnessed-physics-to-help-grow-living-things","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/us\/214672\/","title":{"rendered":"Genes Have Harnessed Physics to Help Grow Living Things"},"content":{"rendered":"

\u201cThe hypothesis is that physics and mechanics can help us understand the biology at the tissue scale,\u201d said Alexandre Kabla<\/a>, a physicist and engineer at the University of Cambridge.<\/p>\n

The task now is to understand the interplay of causes, where genes and physics somehow act hand in hand to sculpt organisms.<\/p>\n

Grow With the Flow <\/p>\n

Mechanical models of embryo and tissue growth are not new, but biologists long lacked ways of testing these ideas. Just seeing embryos is difficult; they are small and diffusive, bouncing light in all directions like frosted glass. But new microscopy and image analysis techniques have opened a clearer window on development.<\/p>\n

Lenne and his co-workers applied some of the new techniques to observe the motion of cells inside mouse gastruloids: bundles of stem cells that, as they grow, mimic the early stages of embryo growth.<\/p>\n

\"Two <\/p>\n

Sham Tlili (left), Pierre-Fran\u00e7ois Lenne (right), and their Aix Marseille University colleagues Simon Gsell and Matthias Merkel have unraveled a Marangoni-like flow pattern that occurs in the early stages of embryogenesis.<\/p>\n

Courtesy of Pierre Francois Lenne<\/p>\n

Their observations revealed that cells flow up the sides of the gastruloid, then form a stream of tissue flowing down the middle. For Lenne, the system brought to mind a droplet, and on reviewing the literature on the surface tension in a moving droplet, he hit upon the Marangoni effect.<\/p>\n

James Thomson\u2019s 1855 description of the Marangoni effect explained how, when two liquids that have different surface tensions meet, the fluid with the higher surface tension will pull on the other. This happens because surface tension is just the tendency of the outermost molecules in a fluid to be drawn inward by neighboring molecules. When two fluids meet, the higher-tension fluid will have a stronger pull, so the lower-tension fluid will move in the higher-tension fluid\u2019s direction. In a wineglass, the alcohol on the wetted sides of the glass evaporates quickly, leaving a more watery liquid behind. Water has a higher surface tension than alcohol, so the watery sides drag the wine in the glass up to the top of the wetted area. It eventually drips down under its own weight, forming \u201ctears.\u201d<\/p>\n

This flow of the wine up the sides and down again is similar to the flow of the tissue in the gastruloid. Indeed, when the team tested a model of Marangoni-type gastruloid tissue flow, they found what they considered a striking fit with their experimental data.<\/p>\n

\"\"\"\" <\/p>\n

Mark Belan\/Quanta Magazine; Source: Pierre-Fran\u00e7ois Lenne<\/p>\n

The Marangoni flow is a mechanical effect, but genes are involved too: They set up the surface tension difference. At first, genes produce a higher concentration of two particular proteins in one part of the blob of cells. These proteins lead to lower surface tension, and so tissue flows away from that region. The tissue moves around the periphery of the gastruloid before recirculating down its center \u2014 just as wine tears drip back down the side of a glass. The process elongates the gastruloid. It\u2019s \u201ca very nice example of how mechanics, coupled with all the intrinsic complexity of molecular and cellular biology, has a very important role in shaping organisms,\u201d Kabla said.\u00a0<\/p>\n

Scales of a Feather<\/p>\n

In 2017, Alan Rodrigues<\/a> and Amy Shyer<\/a> couldn\u2019t find what they were looking for. The pair, co-leaders of Rockefeller University\u2019s Laboratory of Morphogenesis, had been trying to figure out how the regular spacing of a bird\u2019s feathers comes about. The popular theory at the time was that bird embryos secrete special molecules called morphogens across their skin tissues. These morphogens would then prompt genes to produce proteins at the right places to form follicles. But the researchers couldn\u2019t find any genetic signal that would start the process.<\/p>\n

\"A <\/p>\n

Amy Shyer and Alan Rodrigues, co-leaders of Rockefeller University\u2019s Laboratory of Morphogenesis, have homed in on the role of mechanics in shaping bird feather follicles.<\/p>\n

Courtesy of Amy Shyer; Courtesy of Alan Rodrigues<\/p>\n

They came to suspect that mechanical and tensile forces were playing a significant role. In a 2023 report in Science<\/a>, their team found that morphogens were indeed secreted just before a feather follicle started to bud. But the morphogens didn\u2019t seem to be influencing development on the level of individual cells. Instead, they were influencing larger swaths of tissue. The morphogens affected the tissue\u2019s material properties, setting the stage for mechanical forces to push and pull on the tissue for follicle patterning.<\/p>\n

\u201cWhat\u2019s really amazed us is that you might be able to get by with a relatively simple amount of instruction from the genetic and molecular level,\u201d said Rodrigues. \u201cBecause you have additional emergent processes and properties happening at other levels.\u201d<\/p>\n

For Rodrigues, the big issue is how the various processes work together across length scales, from genes to cells to tissues. It\u2019s not that everything starts on the smallest scales and builds from there. In the case of avian feather follicle development, changes at the molecular and tissue levels emerge together. The work \u201cchallenges the general view across much of biology,\u201d Rodrigues said, \u201cthat regulation or causation emerges at the molecular level and then feeds upward across scales to dictate high-level properties such as form.\u201d<\/p>\n

Springing Into Action<\/p>\n

Some proteins do affect material properties within individual cells, setting the stage for mechanical forces to act at that level too. For instance, during the embryogenesis of a fruit fly, cells in the embryo don\u2019t just rearrange themselves; Kabla and his co-authors discovered that the cells also stretch. This stretching appears to be directly attributable to gene activity that results in a curious characteristic of the cells\u2019 stretchiness.<\/p>\n

Take a spring or an elastic material like a rubber band, and the material will extend in proportion to the force applied. This relationship is known as Hooke\u2019s law, and it holds quite generally. Unless, that is, the object being stretched is in some kind of viscous fluid, in which case the amount of extension also depends on time. (Think of stirring molasses: It\u2019s hard to stir fast.)<\/p>\n

\"Side-by-side <\/p>\n

Figures from D\u2019Arcy Thompson\u2019s 1917 tome On Growth and Form.<\/p>\n

Biological organisms appear to share this dependence on time. Several groups have measured the stretching of certain cells in the fruit fly embryo and found that their extension depends on the square root of the amount of time the force is applied. The question then becomes: Where does this behavior come from?<\/p>\n

In a paper in Physical Review Letters<\/a> in June, Konstantin Doubrovinski and colleagues at the University of Texas Southwestern Medical Center explain it in terms of the production of actin, one of the most abundant proteins in these cells. They suggest that the actin filaments effectively pull on the cell like springs as they are produced, creating resistance to the force that stretches the cells and giving rise to the observed behavior.<\/p>\n

Doubrovinski and his team verified the role of actin by repeating the experiment using drugs that prevent the actin protein from assembling. \u201cEssentially, the elastic response more or less completely goes away,\u201d he said.<\/p>\n

Kabla says that while the study makes a strong case, discussion of the stretching behavior continues. One of the challenges facing biology, he points out, is figuring out what is causing what, and whether a given phenomenon is a key driver of change, a contributing factor, or an unimportant consequence.<\/p>\n

These questions echo similar debates<\/a> over the biological significance of the geometric similarities D\u2019Arcy Thompson cataloged more than 100 years ago. But Thompson\u2019s central argument that these geometric forms result from underlying physical forces is standing up to modern scrutiny.<\/p>\n

\u201cTo many of us,\u201d Kabla said, \u201cit seems natural that where there\u2019s motion, mechanics is likely to be involved.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"\u201cThe hypothesis is that physics and mechanics can help us understand the biology at the tissue scale,\u201d said…\n","protected":false},"author":2,"featured_media":214673,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[49],"tags":[199,79],"class_list":{"0":"post-214672","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-physics","8":"tag-physics","9":"tag-science"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/214672","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/comments?post=214672"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/214672\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media\/214673"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media?parent=214672"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/categories?post=214672"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/tags?post=214672"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}