{"id":229725,"date":"2025-10-16T19:19:10","date_gmt":"2025-10-16T19:19:10","guid":{"rendered":"https:\/\/www.newsbeep.com\/us\/229725\/"},"modified":"2025-10-16T19:19:10","modified_gmt":"2025-10-16T19:19:10","slug":"cancer-vaccine-blocks-multiple-tumors-in-mice-for-250-days-sciencealert","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/us\/229725\/","title":{"rendered":"Cancer Vaccine Blocks Multiple Tumors in Mice For 250 Days : ScienceAlert"},"content":{"rendered":"

A new vaccine can effectively prevent multiple types of cancer<\/a>, with up to 88 percent efficacy for some forms of tumor in mouse tests.<\/p>\n

Like a vaccine designed to prevent or reduce illness from viral infections<\/a>, this cancer vaccine works by training the immune system to attack tumors when they next appear.<\/p>\n

Nanoparticles in the vaccine present a recognizable component of cancer cells as an antigen \u2013 a label that alerts our immune cells to a threat. A second material, described as a ‘super’ adjuvant<\/a>, further stimulates the immune system to go on the offensive.<\/p>\n

Related: ‘Universal’ Cancer Vaccine Destroys Resistant Tumors in Mice<\/a><\/p>\n

In the first tests, scientists at the University of Massachusetts Amherst vaccinated a group of mice with nanoparticles containing melanoma peptides, before exposing the test animals to melanoma cells a few weeks later.<\/p>\n

Of the mice that received the nanoparticle vaccine, 80 percent survived and stayed tumor-free for the 250-day duration of the study. By contrast, all of the mice that weren’t vaccinated or were given different formulations succumbed within seven weeks.<\/p>\n

In the second test, the team used a more general antigen \u2013 a substance called tumor lysate, made of broken-up cancer cells. It was hypothesized that the lysate may alert the immune system to a range of cancer types, which would be helpful in preventative cases.<\/p>\n

Mice were given this version of the vaccine before being exposed to either melanoma, pancreatic, or triple-negative breast cancer. And again, the majority remained tumor-free: 88 percent of those exposed to pancreatic cancer, 75 percent for breast cancer, and 69 percent for melanoma.<\/p>\n

\"CancerA graphical abstract of how the cancer vaccine works. (Kane et al., Cell Rep. Med. 2025)<\/p>\n

The researchers unsuccessfully attempted to simulate the spread of cancer in the surviving mice, finding 100 percent of them remained tumor-free.<\/p>\n

“By engineering these nanoparticles to activate the immune system via multi-pathway activation that combines with cancer-specific antigens, we can prevent tumor growth with remarkable survival rates,” says<\/a> Prabhani Atukorale, biomedical engineer at UMass Amherst.<\/p>\n

The team says the key is the so-called super adjuvant, which consists of lipid nanoparticles that encapsulate two immune adjuvants and deliver them together to boost the immune response.
\"Mid<\/a>
Of course, at this stage, the work has only been conducted in mice, so there’s no guarantee that results will translate to humans.<\/p>\n

But this technique could potentially be adaptable to a range of different cancer types, helping to both treat patients after diagnosis<\/a> and prevent cancer from taking hold in high-risk patients.<\/p>\n

The research was published in the journal Cell Reports Medicine<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"A new vaccine can effectively prevent multiple types of cancer, with up to 88 percent efficacy for some…\n","protected":false},"author":2,"featured_media":229726,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[97,1352],"class_list":["post-229725","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-msft-content"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/229725","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/comments?post=229725"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/229725\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media\/229726"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media?parent=229725"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/categories?post=229725"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/tags?post=229725"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}