{"id":273093,"date":"2025-11-05T13:34:12","date_gmt":"2025-11-05T13:34:12","guid":{"rendered":"https:\/\/www.newsbeep.com\/us\/273093\/"},"modified":"2025-11-05T13:34:12","modified_gmt":"2025-11-05T13:34:12","slug":"skye-bioscience-shows-18-1-vs-49-8-weight-regain-in-phase-2","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/us\/273093\/","title":{"rendered":"Skye Bioscience Shows 18.1% vs 49.8% Weight Regain in Phase 2"},"content":{"rendered":"


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Skye Bioscience (Nasdaq: SKYE) will present a late-breaking oral abstract at ObesityWeek 2025 on November 7, 2025 summarizing topline CBeyond\u2122 Phase 2 data.<\/p>\n

Key findings: nimacimab 200 mg weekly plus semaglutide blunted 12-week post-treatment weight regain (18.1% vs 49.8%), maintained significant weight loss vs placebo at 12 weeks post-treatment (p=0.006), and previously produced additional on\u2011treatment weight loss (-13.2% vs -10.25%, p=0.0372). Waist circumference improved by 3.17 cm more versus semaglutide alone (p=0.0492). Presentation: Dr. Louis Aronne, Nov 7, 2025, 9:15\u20139:30am EDT, GWCC-A411-A412.<\/p>\n

Skye Bioscience (Nasdaq: SKYE) presenter\u00e0 un abstract orale dell’ultima ora a ObesityWeek 2025 il 7 novembre 2025 riassumendo i dati di fase 2 topline di CBeyond\u2122.<\/p>\n

Scoperte chiave: nimacimab 200 mg settimanali pi\u00f9 semaglutide hanno attenuato il recupero di peso 12 settimane dopo il trattamento (18,1% contro 49,8%), mantenuto una perdita di peso significativa rispetto al placebo a 12 settimane dal termine del trattamento (p=0,006), e in precedenza ha prodotto ulteriori perdite di peso durante il trattamento (-13,2% vs -10,25%, p=0,0372). La circonferenza della vita \u00e8 migliorata di 3,17 cm rispetto al solo semaglutide (p=0,0492). Presentazione: Dr. Louis Aronne, 7 nov 2025, ore 9:15\u20139:30 EDT, GWCC-A411-A412.<\/p>\n

Skye Bioscience (Nasdaq: SKYE) presentar\u00e1 un resumen oral de \u00faltima hora en ObesityWeek 2025 el 7 de noviembre de 2025 resumiendo los datos de fase 2 topline de CBeyond\u2122.<\/p>\n

Principales hallazgos: nimacimab 200 mg semanal m\u00e1s semaglutida atenuaron la ganancia de peso de 12 semanas post-tratamiento (18,1% frente a 49,8%), mantuvieron una p\u00e9rdida de peso significativa frente a placebo a las 12 semanas post-tratamiento (p=0,006), y previamente produjeron una p\u00e9rdida adicional de peso durante el tratamiento (-13,2% frente a -10,25%, p=0,0372). La circunferencia de la cintura mejor\u00f3 en 3,17 cm frente a solo semaglutida (p=0,0492). Presentaci\u00f3n: Dr. Louis Aronne, 7 de nov de 2025, 9:15\u20139:30 a.m. EDT, GWCC-A411-A412.<\/p>\n

Skye Bioscience (Nasdaq: SKYE)\ub294 ObesityWeek 2025\uc5d0\uc11c 2025\ub144 11\uc6d4 7\uc77c\uc5d0 CBeyond\u2122 2\uc0c1 topline \ub370\uc774\ud130\ub97c \uc694\uc57d\ud558\ub294 \ucd5c\uc2e0 \uad6c\ub450 \ucd08\ub85d\uc744 \ubc1c\ud45c\ud569\ub2c8\ub2e4.<\/p>\n

\ud575\uc2ec \ubc1c\uacac: nimacimab 200 mg \uc8fc 1\ud68c\uc640 \uc138\ub9c8\uae00\ub8e8\ud0c0\uc774\ub4dc\uc758 \ubcd1\uc6a9\uc740 \uce58\ub8cc \uc885\ub8cc \ud6c4 12\uc8fc \uac04\uc758 \uccb4\uc911 \ud68c\ubcf5\uc744 \uc800\ud558\uc2dc\ucf30\uc73c\uba70 (18.1% \ub300 49.8%), \uce58\ub8cc \uc885\ub8cc 12\uc8fc \ud6c4 \uc704\uc57d \ub300\ube44 \uc720\uc758\ud558\uac8c \uccb4\uc911 \uac10\uc18c\ub97c \uc720\uc9c0\ud588\uace0(p=0.006), \uadf8\ub9ac\uace0 \uc774\uc804\uc5d0 \uce58\ub8cc \uc911 \ucd94\uac00 \uccb4\uc911 \uac10\uc18c\ub97c \ubc1c\uc0dd\uc2dc\ucf30\uc2b5\ub2c8\ub2e4(-13.2% \ub300 -10.25%, p=0.0372). \ud5c8\ub9ac\ub458\ub808\ub3c4 \uc138\ub9c8\uae00\ub8e8\ud0c0\uc774\ub4dc \ub2e8\ub3c5\ubcf4\ub2e4 3.17 cm \ub9cc\ud07c \uac1c\uc120\ub418\uc5c8\uc2b5\ub2c8\ub2e4(p=0.0492). \ubc1c\ud45c: Dr. Louis Aronne, 2025\ub144 11\uc6d4 7\uc77c, \uc624\uc804 9:15\u20139:30 EDT, GWCC-A411-A412.<\/p>\n

Skye Bioscience (Nasdaq: SKYE) pr\u00e9sentera un r\u00e9sum\u00e9 oral de derni\u00e8re minute \u00e0 ObesityWeek 2025 le 7 novembre 2025 r\u00e9sumant les donn\u00e9es topline de la phase 2 CBeyond\u2122.<\/p>\n

Principales conclusions: nimacimab 200 mg hebdomadaire plus s\u00e9maglutide ont att\u00e9nu\u00e9 la reprise de poids 12 semaines apr\u00e8s le traitement (18,1% vs 49,8%), maintenu une perte de poids significative par rapport au placebo \u00e0 12 semaines apr\u00e8s le traitement (p=0,006), et ont pr\u00e9c\u00e9demment produit une perte de poids suppl\u00e9mentaire pendant le traitement (-13,2% vs -10,25%, p=0,0372). Le tour de taille s’est am\u00e9lior\u00e9 de 3,17 cm par rapport au seul s\u00e9maglutide (p=0,0492). Pr\u00e9sentation: Dr. Louis Aronne, 7 nov. 2025, 9:15\u20139:30 EDT, GWCC-A411-A412.<\/p>\n

Skye Bioscience (Nasdaq: SKYE) wird auf der ObesityWeek 2025 am 7. November 2025 einen neuesten m\u00fcndlichen Abstract vorstellen, der topline CBeyond\u2122 Phase-2-Daten zusammenfasst.<\/p>\n

Zentrale Ergebnisse: Nimacimab 200 mg w\u00f6chentlich plus Semaglutid d\u00e4mpften die Gewichtszunahme 12 Wochen nach der Behandlung (18,1% vs 49,8%), behielten eine signifikante Gewichtsabnahme gegen\u00fcber Placebo 12 Wochen nach der Behandlung bei (p=0,006), und hatten zuvor w\u00e4hrend der Behandlung zus\u00e4tzliches Gewicht (-13,2% vs -10,25%, p=0,0372). Taillenumfang verbesserte sich um 3,17 cm gegen\u00fcber Semaglutid allein (p=0,0492). Pr\u00e4sentation: Dr. Louis Aronne, 7. Nov 2025, 9:15\u20139:30 Uhr EDT, GWCC-A411-A412.<\/p>\n

Skye Bioscience (Nasdaq: SKYE) \u0633\u062a\u0642\u062f\u0645 \u0645\u0644\u062e\u0635\u064b\u0627 \u0634\u0641\u0647\u064a\u064b\u0627 \u0639\u0627\u062c\u0644\u0627\u064b \u0641\u064a ObesityWeek 2025 \u0641\u064a 7 \u0646\u0648\u0641\u0645\u0628\u0631 2025 \u064a\u0644\u062e\u0651\u0635 \u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0645\u0631\u062d\u0644\u0629 2 \u0645\u0646 CBeyond\u2122 topline.<\/p>\n

\u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629: nimacimab 200 mg \u0623\u0633\u0628\u0648\u0639\u064a\u064b\u0627 \u0645\u0639 \u0633\u064a\u0645\u064a\u0627\u063a\u0644\u0648\u062a\u064a\u062f \u062e\u0641\u0651\u0636\u0627 \u0627\u0633\u062a\u0639\u0627\u062f\u0629 \u0627\u0644\u0648\u0632\u0646 \u0628\u0639\u062f 12 \u0623\u0633\u0628\u0648\u0639\u064b\u0627 \u0645\u0646 \u0627\u0644\u0639\u0644\u0627\u062c (18.1% \u0645\u0642\u0627\u0628\u0644 49.8%)\u060c \u0648\u0623\u0628\u0642\u064a\u0627 \u0641\u0642\u062f\u0627\u0646 \u0648\u0632\u0646 \u0645\u0647\u0645 \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0648\u0647\u0645\u064a \u0639\u0646\u062f 12 \u0623\u0633\u0628\u0648\u0639\u064b\u0627 \u0628\u0639\u062f \u0627\u0644\u0639\u0644\u0627\u062c (p=0.006)\u060c \u0648\u0628\u0631\u0648\u062d\u064d \u0645\u0646 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0633\u0627\u0628\u0642 \u0623\u064e\u0646\u062a\u062c \u0641\u0642\u062f\u0627\u0646 \u0648\u0632\u0646 \u0625\u0636\u0627\u0641\u064a \u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u0639\u0644\u0627\u062c (-13.2% \u0645\u0642\u0627\u0628\u0644 -10.25%, p=0.0372). \u062a\u062d\u0633\u0646 \u0645\u062d\u064a\u0637 \u0627\u0644\u062e\u0635\u0631 \u0628\u0645\u0642\u062f\u0627\u0631 3.17 \u0633\u0645 \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0633\u064a\u0645\u064a\u0627\u063a\u0644\u0648\u062a\u064a\u062f \u0648\u062d\u062f\u0647 (p=0.0492). \u0627\u0644\u0639\u0631\u0636 \u0627\u0644\u062a\u0642\u062f\u064a\u0645\u064a: \u0627\u0644\u062f\u0643\u062a\u0648\u0631 \u0644\u0648\u064a\u0633 \u0623\u0631\u0648\u0646\u064a\u060c 7 \u0646\u0648\u0641\u0645\u0628\u0631 2025\u060c 9:15\u20139:30 \u0635\u0628\u0627\u062d\u064b\u0627 \u0628\u062a\u0648\u0642\u064a\u062a EDT\u060c GWCC-A411-A412.<\/p>\n

Positive<\/p>\n


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\n Post-treatment weight regain reduced to 18.1% vs 49.8%
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\n On-treatment weight loss -13.2% vs -10.25% (p=0.0372)
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\n Waist circumference improved by 3.17 cm (p=0.0492)
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\n Maintained significance vs placebo at 12 weeks post-treatment (p=0.006)
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Negative<\/p>\n


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\n Nimacimab 200 mg monotherapy did not produce significant weight loss
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\n Semaglutide alone lost significance vs placebo at 12 weeks post-treatment (p=0.12)
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<\/p>\n


\n Insights \n <\/p>\n


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Phase 2 data show nimacimab plus semaglutide reduced rebound weight gain and preserved post\u2011treatment benefit through 12-week.<\/p>\n

In the CBeyond\u2122 Phase 2 subset, the combination of nimacimab 200 mg weekly with semaglutide produced less rebound weight regain over a 12-week post\u2011treatment window (18.1% vs 49.8%) and maintained significant separation from placebo (p=0.006). The combination also showed greater absolute weight loss at Week 26-week (-13.2% vs -10.25%, p=0.0372) and a modest additional reduction in waist circumference (-3.17cm, p=0.0492). These are concrete efficacy signals that support pharmacologic activity when nimacimab is added to a GLP\u20111 agonist.<\/p>\n

The robustness of the finding depends on sample size, multiplicity adjustment, and whether the presented results derive from a pre\u2011specified analysis population; those details are not provided here. Safety is described as not adding concerns, but no specific adverse event rates are reported, so safety interpretation remains limited. Watch the late\u2011breaking oral presentation on November 7, 2025 for full methods, sample counts, subgroup definitions, and detailed safety tables within 30\u201390 days to assess reproducibility and clinical relevance.<\/p>\n


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\n 11\/05\/2025 – 07:05 AM
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During 12-week post-treatment period, nimacimab plus semaglutide blunts weight regain compared to semaglutide alone in subset analysis<\/p>\n

SAN DIEGO, Nov. 05, 2025 (GLOBE NEWSWIRE) — Skye Bioscience, Inc. (Nasdaq: SKYE<\/a>) (\u201cSkye\u201d), a clinical-stage biotechnology company focused on unlocking new therapeutic pathways for obesity and other metabolic health disorders, today announced that it will present a late-breaking oral presentation at ObesityWeek 2025 on November 7, 2025, in Atlanta, Georgia. The presentation will highlight recent topline data from CBeyond\u2122, a Phase 2 proof-of-concept study of nimacimab, Skye\u2019s peripherally-restricted CB1 inhibitor antibody.<\/p>\n

New data from an analysis of participants 12 weeks post-treatment demonstrated that nimacimab 200 mg (subcutaneous, weekly) plus semaglutide blunted rebound weight gain compared to semaglutide alone (18.1% versus 49.8% weight regain over 12 weeks). Moreover, at 12 weeks post-treatment, the nimacimab plus semaglutide group maintained significant weight loss compared to the placebo group (p=0.006), while the semaglutide alone group lost significance over the placebo group (p=0.12) and followed a trajectory of rebound weight gain consistent with previously reported data (Wilding et al., 2022, STEP-1 Trial Extension), which demonstrated that patients will gain a majority of weight back within 1-year of stopping treatment with semaglutide. Previously reported results showed that nimacimab 200 mg (subcutaneous, weekly) plus semaglutide achieved additional weight loss compared to semaglutide alone (-13.2% vs -10.25%, p=0.0372, mITT), with no plateau being observed through Week 26.<\/p>\n

Skye also reported changes in waist circumference, a key secondary endpoint. Nimacimab plus semaglutide showed a least-means squared (SE) change of -11.26cm (1.16cm) in waist circumference versus -8.09cm (1.2cm) for semaglutide alone, resulting in a difference of -3.17cm (1.59cm) (p=0.0492).<\/p>\n

Details for the late-breaking abstract oral presentation are:<\/p>\n

Presenter: Dr. Louis Aronne
Presentation Title: CBeyond\u2122, A Phase 2 Trial for Weight Loss with a Peripherally Acting CB1 Receptor Antibody
Presentation Type: Oral Session
Session Date: Friday, November 7, 2025
Session Time: 9:15 \u2013 9:30am EDT
Session Room: GWCC-A411-A412<\/p>\n

\u201cThese new data, including the approximately 30% improvement in weight loss we observed when nimacimab was combined with semaglutide, add to our confidence that nimacimab is clinically active and has a potentially important role for the treatment of obesity,\u201d said Puneet Arora, MD, FACE, Chief Medical Officer at Skye. \u201cWe believe the ability to blunt the weight regain that we typically see when patients stop GLP-1 agonist therapy like semaglutide is clinically significant, and reinforces the target product profile for nimacimab, which can potentially serve multiple needs in the obesity treatment paradigm, not just as a non-incretin add-on or combination, but also potentially in the maintenance setting.\u201d<\/p>\n

Punit Dhillon, President and CEO, added, \u201cWhile nimacimab 200 mg alone did not result in significant weight loss, we are encouraged that this same dose in combination with semaglutide demonstrated 26-week weight loss comparable to tirzepatide and other incretin combinations, without any added safety concerns. These initial monotherapy results have not deterred our development plans for nimacimab since our next steps have always focused on the need to conduct a dose-ranging study to determine the optimal dosing of nimacimab in both monotherapy and combination settings. We are firmly committed to this plan and look forward to providing more details in the near future.\u201d<\/p>\n

About Skye Bioscience <\/p>\n

Skye is focused on unlocking new therapeutic pathways for metabolic health through the development of next-generation molecules that modulate G-protein coupled receptors. Skye’s strategy leverages biologic targets with substantial human proof of mechanism for the development of first-in-class therapeutics with clinical and commercial differentiation. Skye is conducting a Phase 2a clinical trial (ClinicalTrials.gov: NCT06577090<\/a>) in obesity for nimacimab, a negative allosteric modulating antibody that peripherally inhibits CB1. This study is also assessing the combination of nimacimab and a GLP-1R agonist (Wegovy\u00ae). For more information, please visit: www.skyebioscience.com<\/a>. Connect with us on\u00a0LinkedIn<\/a>.<\/p>\n

CONTACTS<\/p>\n

Investor Relations
ir@skyebioscience.com<\/a>
(858) 410-0266<\/p>\n

LifeSci Advisors, Mike Moyer
mmoyer@lifesciadvisors.com<\/a>
(617) 308-4306<\/p>\n

Media Inquiries<\/p>\n

LifeSci Communications, Michael Fitzhugh
mfitzhugh@lifescicomms.com<\/a>
(628) 234-3889<\/p>\n

FORWARD LOOKING STATEMENTS<\/p>\n

This press release includes \u201cforward-looking statements\u201d within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release other than statements of historical fact should be considered forward-looking statements, including, without limitation, statements relating to nimacimab\u2019s potentially important role for the treatment of obesity; nimacimab\u2019s ability to serve multiple roles in the obesity treatment paradigm, including in the maintenance setting; plans to advance nimacimab into the next stage of development to optimize dosing; future clinical development of nimacimab, including the initiation and design of any future clinical trials. When used herein, words including \u201canticipate,\u201d \u201cbelieve,\u201d \u201ccan,\u201d \u201ccontinue,\u201d \u201ccould,\u201d “designed,\u201d \u201cestimate,\u201d \u201cexpect,\u201d \u201cforecast,\u201d \u201cgoal,\u201d \u201cintend,\u201d \u201cmay,\u201d \u201cmight,\u201d \u201cplan,\u201d \u201cplanning,\u201d \u201cpossible,\u201d \u201cpotential,\u201d \u201cpredict,\u201d \u201cproject,\u201d \u201cshould,\u201d \u201ctarget,\u201d \u201cwill,\u201d \u201cwould\u201d and similar expressions are intended to identify forward-looking statements, though not all forward-looking statements use these words or expressions. All forward-looking statements are based upon the Company\u2019s current expectations and various assumptions. The Company believes there is a reasonable basis for its expectations and beliefs, but they are inherently uncertain. The Company may not realize its expectations, and its beliefs may not prove correct. Actual results could differ materially from those described or implied by such forward-looking statements as a result of various important risks and uncertainties, including, without limitation, the initiation and design of any future clinical trials will be impacted by the Company\u2019s capital resources, the Company\u2019s ability to obtain additional sources of capital, program considerations and potentially other factors outside the Company\u2019s control; there is no guarantee that higher dosing of nimacimab will achieve increased efficacy, and likewise it is possible that higher dosing will produce adversely different safety and tolerability results than those observed to date; the Company\u2019s dependence on third parties in connection with product manufacturing; research and preclinical and clinical testing; the Company\u2019s ability to advance, obtain regulatory approval of and ultimately commercialize nimacimab, competitive products or approaches limiting the commercial value of nimacimab; the timing and results of preclinical and clinical trials; the Company\u2019s ability to fund development activities and achieve development goals; the impact of any global pandemics, inflation, supply chain issues, government shutdowns, high interest rates, adverse regulatory changes; the Company\u2019s ability to protect its intellectual property; risks associated with the Company\u2019s common stock and the other important factors discussed under the caption \u201cRisk Factors\u201d in the Company\u2019s filings with the Securities and Exchange Commission, including in its Annual Report on Form 10-K for the year ended December 31, 2024, which are accessible on the SEC\u2019s website at www.sec.gov and the Investors section of the Company\u2019s website. Any such forward-looking statements represent management\u2019s estimates as of the date of this press release. While the Company may elect to update such forward-looking statements at some point in the future, except as required by law, it disclaims any obligation to do so, even if subsequent events cause the Company\u2019s views to change. These forward-looking statements should not be relied upon as representing the Company\u2019s views as of any date subsequent to the date of this press release.<\/p>\n

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\n FAQ \n <\/p>\n


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What did Skye Bioscience (SKYE) report about post-treatment weight regain on November 5, 2025?<\/p>\n


\n Skye reported nimacimab plus semaglutide reduced 12-week post-treatment weight regain to 18.1% versus 49.8% with semaglutide alone. \n <\/p>\n


\n <\/p>\n

How much additional weight loss did SKYE’s nimacimab add to semaglutide in the Phase 2 topline results?<\/p>\n


\n Nimacimab plus semaglutide achieved -13.2% weight loss versus -10.25% for semaglutide alone (p=0.0372). \n <\/p>\n


\n <\/p>\n

When and where will Skye (SKYE) present the CBeyond Phase 2 data at ObesityWeek 2025?<\/p>\n


\n Presentation is on November 7, 2025 at 9:15\u20139:30am EDT in room GWCC-A411-A412, Atlanta. \n <\/p>\n


\n <\/p>\n

Did SKYE report meaningful changes in waist circumference in the CBeyond study?<\/p>\n


\n Yes. Nimacimab plus semaglutide showed a 3.17 cm greater reduction versus semaglutide alone (p=0.0492). \n <\/p>\n


\n <\/p>\n

Was nimacimab effective as a standalone treatment in SKYE’s Phase 2 results?<\/p>\n


\n No. The release states nimacimab 200 mg alone did not result in significant weight loss. \n <\/p>\n


\n <\/p>\n

What statistical significance did SKYE report for weight maintenance at 12 weeks post-treatment?<\/p>\n


\n The nimacimab plus semaglutide group remained significant versus placebo at 12 weeks post-treatment (p=0.006), while semaglutide alone did not (p=0.12). \n <\/p>\n


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