{"id":278113,"date":"2025-11-07T22:42:10","date_gmt":"2025-11-07T22:42:10","guid":{"rendered":"https:\/\/www.newsbeep.com\/us\/278113\/"},"modified":"2025-11-07T22:42:10","modified_gmt":"2025-11-07T22:42:10","slug":"jupiters-oral-resveratrol-jotrol-cleared-for-phase-2a-trial-by-fda","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/us\/278113\/","title":{"rendered":"Jupiter’s oral resveratrol Jotrol cleared for Phase 2a trial by FDA"},"content":{"rendered":"

Jotrol, an oral formulation of the natural compound resveratrol, has been cleared for testing in people with Parkinson\u2019s disease<\/a> by the U.S. Food and Drug Administration (FDA).<\/p>\n

Jupiter Neurosciences<\/a> will conduct the Phase 2a clinical trial with Zina Biopharmaceuticals<\/a> to evaluate the safety, tolerability, and pharmacological properties of the treatment, which is designed to harness the anti-inflammatory and antioxidant benefits of resveratrol in a capsule.\u00a0Enrollment is expected to begin in early 2026.<\/p>\n

\u201cThis \u2026 clearance from the FDA is an important step forward for Jupiter and the Parkinson\u2019s community,\u201d Christer Ros\u00e9n, Jupiter\u2019s chairman and CEO, said in a company press release<\/a>. \u201cWe are proud to advance this innovative program and are now one step closer to initiating patient dosing.\u201d<\/p>\n

Recommended Reading<\/p>\n

\"A<\/p>\n

Understanding Parkinson\u2019s and resveratrol\u2019s potential<\/p>\n

Parkinson\u2019s disease is caused<\/a> by the dysfunction and death of dopaminergic neurons, or the nerve cells that produce dopamine, a signaling molecule that nerve cells use to communicate. The loss of dopamine signaling leads to disease symptoms<\/a>, including\u00a0movement and cognitive issues.<\/p>\n

Although the exact trigger for the loss of dopaminergic neurons is not fully understood, neuroinflammation and oxidative stress, a type of cellular damage, are known to be involved. Resveratrol is a naturally occurring compound found in certain plants, such as red grapes, that possesses anti-inflammatory and antioxidant properties, which can help lower inflammation and oxidative stress.<\/p>\n

Despite its potential to treat Parkinson\u2019s, when taken orally at high doses, resveratrol may lead to digestive side effects. Jotrol<\/a> is a new formulation where the compound is contained in a micellar structure, meaning it is dissolved as a soft gel that can be easily consumed as an oral capsule.<\/p>\n

Additionally, Jotrol can cross the blood-brain barrier, a tight layer of cells lining the brain\u2019s blood vessels, that prevents certain molecules, including medications, from entering the brain. This means the treatment can reach the brain and has the potential to treat neurological diseases.<\/p>\n

According to the company, preclinical studies have demonstrated that Jotrol can improve motor function in a mouse model of Parkinson\u2019s. Particularly, Jotrol was found to have a nine times higher bioavailability, or the ability of a substance to be absorbed and used by the body, than traditional resveratrol oral formulations.<\/p>\n

Results<\/a> from a Phase 1 trial (NCT04668274)<\/a> have shown that Jotrol can deliver a therapeutically effective dose without the gastrointestinal side effects that have limited resveratrol\u2019s therapeutic use.<\/p>\n

\u201cJotrol\u2019s unique formulation has demonstrated strong safety and bioavailability data in Phase I and preclinical evidence suggests neuroprotective benefits that may translate into disease-modifying potential in Parkinson\u2019s,\u201d Ros\u00e9n said.<\/p>\n","protected":false},"excerpt":{"rendered":"Jotrol, an oral formulation of the natural compound resveratrol, has been cleared for testing in people with Parkinson\u2019s…\n","protected":false},"author":2,"featured_media":278114,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[61],"tags":[97,269],"class_list":{"0":"post-278113","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-nutrition","8":"tag-health","9":"tag-nutrition"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/278113","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/comments?post=278113"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/278113\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media\/278114"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media?parent=278113"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/categories?post=278113"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/tags?post=278113"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}