PA Media\/dpa(TNS)<\/p>\n
London \u2014 Existing evidence does not show a clear link between taking Tylenol in pregnancy and autism and ADHD<\/a> in children, an in-depth review has concluded.<\/p>\n Researchers trawled all studies<\/a> on the issue and concluded they were low quality, with \u201clow to critically low\u201d confidence in any findings suggesting a link.<\/p>\n U.S. President Donald Trump said<\/a> in September there has been a \u201cmeteoric rise\u201d in cases of autism and that Tylenol, or acetaminophen \u2013 which is called paracetamol in the UK \u2013 was a potential cause.<\/p>\n Trump said the painkiller should not be taken during pregnancy, suggesting pregnant women should \u201ctough it out.\u201d His comments were criticized by autism campaigners and scientists in the UK and around the world.<\/p>\n Now in a new study, published in the British Medical Journal (BMJ), experts including from the universities of Liverpool and Birmingham concluded that women should continue to be advised to take acetaminophen \/ paracetamol when needed to treat pain and fever in pregnancy.<\/p>\n They said there was a \u201clack of robust evidence linking paracetamol use in pregnancy and autism and ADHD in offspring.\u201d<\/p>\n Furthermore, untreated fever, particularly in the first trimester, has been linked to an increased risk of miscarriage, birth defects and premature birth \u2013 underlining the need for women to be able to take paracetamol.<\/p>\n The team also suggested that any apparent link between paracetamol and autism and ADHD in previous studies may be driven by shared genetic and environmental factors within families.<\/p>\n For the latest study, researchers examined nine systematic reviews that included a total of 40 observational studies reporting on paracetamol use during pregnancy and the risk of autism, ADHD, or other neurodevelopmental outcomes.<\/p>\n All reviews reported a possible to strong association between a mother\u2019s paracetamol intake and autism or ADHD, or both, in children, but seven of the nine reviews advised caution when interpreting the findings.<\/p>\n Overall, experts in the BMJ concluded that confidence in the findings of these reviews was low (for two reviews) to critically low (for seven reviews).<\/p>\n They added: \u201cExisting evidence does not show a clear link between in utero exposure to paracetamol and autism and ADHD in offspring.<\/p>\n \u201cAny apparent effect observed after in utero exposure to paracetamol on autism and ADHD in childhood might be driven by familial genetic and environmental factors and unmeasured confounders.\u201d<\/p>\n Dimitrios Siassakos, professor in obstetrics and gynaecology from University College London, said: \u201cThe high-quality methodology used in this new umbrella review confirms what experts around the globe have been saying.<\/p>\n \u201cThe evidence that links paracetamol use in pregnancy to autism is tenuous and those studies which do report an association are confounded by the association of autism or ADHD with factors shared by families such as genetics and lifestyle.\u201d<\/p>\n \u00a92025 dpa GmbH. 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