\u00a0<\/p>\n
As filed with the Securities and Exchange Commission
\non July 11, 2025<\/p>\n
\u00a0<\/p>\n
Registration No. 333-__________<\/p>\n
\u00a0<\/p>\n
UNITED STATES<\/p>\n
SECURITIES AND EXCHANGE COMMISSION<\/p>\n
Washington, D.C. 20549<\/p>\n
\u00a0<\/p>\n
FORM S-8<\/p>\n
\u00a0<\/p>\n
REGISTRATION STATEMENT UNDER<\/p>\n
THE SECURITIES ACT OF 1933<\/p>\n
\u00a0<\/p>\n
SOPHiA GENETICS SA<\/p>\n
(Exact name of registrant as specified in its charter)<\/p>\n
\u00a0<\/p>\n
Switzerland
\n \u00a0
\n Not Applicable<\/p>\n
(State or other jurisdiction of<\/p>\n
incorporation or organization)<\/p>\n
\u00a0<\/p>\n
(I.R.S. Employer<\/p>\n
Identification No.)<\/p>\n
\u00a0<\/p>\n
La Pi\u00e8ce 12, CH-1180 Rolle, Switzerland<\/p>\n
(Address of Principal Executive Offices)<\/p>\n
\u00a0<\/p>\n
\u00a0<\/p>\n
SOPHiA
\nGENETICS SA 2021 Equity Incentive Plan <\/p>\n
(Full title of the plan)<\/p>\n
\u00a0<\/p>\n
\u00a0<\/p>\n
SOPHiA GENETICS, Inc.<\/p>\n
401 Park Drive, Suite 505<\/p>\n
Boston, MA 02215<\/p>\n
(Name and Address of Agent For Service)<\/p>\n
\u00a0<\/p>\n
(617) 982-1210<\/p>\n
(Telephone number, Including Area Code, of Agent For Service)<\/p>\n
\u00a0<\/p>\n
\u00a0<\/p>\n
Copies of all communications, including all communications sent
\nto the agent for service, should be sent to:<\/p>\n
Kyoko Takahashi Lin<\/p>\n
Davis Polk & Wardwell LLP<\/p>\n
450 Lexington Avenue<\/p>\n
New York, NY 10017<\/p>\n
(212) 450-4000<\/p>\n
\u00a0<\/p>\n
\u00a0<\/p>\n
Indicate by check mark whether the registrant is a large accelerated
\nfiler, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of
\n\u201clarge accelerated filer,\u201d \u201caccelerated filer,\u201d \u201csmaller reporting company\u201d and \u201cemerging growth
\ncompany\u201d in Rule 12b-2 of the Exchange Act.<\/p>\n
\u00a0<\/p>\n
Large accelerated filer o
\n \u00a0
\n Accelerated filer x<\/p>\n
Non-accelerated filer o
\n \u00a0
\n Smaller reporting company o<\/p>\n
\u00a0<\/p>\n
(Do not check if a smaller reporting company)
\n \u00a0
\n Emerging Growth Company x<\/p>\n
\u00a0<\/p>\n
If an emerging growth company, indicate by check mark if the registrant
\nhas elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
\nto Section 7(a)(2)(B) of the Securities Act. o<\/p>\n
\u00a0<\/p>\n
PART I<\/p>\n
\u00a0<\/p>\n
INFORMATION REQUIRED IN
\nTHE SECTION 10(a) PROSPECTUS<\/p>\n
\u00a0<\/p>\n
Pursuant to General Instruction E to Form S-8,
\nSOPHiA GENETICS SA (the \u201cRegistrant\u201d) is filing this Registration Statement on Form S-8 (this \u201cRegistration
\nStatement\u201d) with the U.S. Securities and Exchange Commission (the \u201cCommission\u201d) to register 15,693,055 additional
\nordinary shares, par value CHF 0.05 per share, of the Registrant (the \u201cShares\u201d), for issuance under the Registrant\u2019s
\n2021 Equity Incentive Plan. This Registration Statement hereby incorporates by reference the contents of the Registrant\u2019s registration
\nstatements on Form S-8 filed with the Commission on July 23, 2021 (Registration No. 333-258121). In accordance with the instructional
\nnote to Part I of Form S-8 as promulgated by the Commission, the information specified by Part I of Form S-8 has been omitted from this
\nRegistration Statement.<\/p>\n
\u00a0<\/p>\n
PART II<\/p>\n
\u00a0<\/p>\n
INFORMATION REQUIRED IN
\nTHE REGISTRATION STATEMENT<\/p>\n
\u00a0<\/p>\n
Item 3. Incorporation of Documents by Reference.<\/p>\n
\u00a0<\/p>\n
The following documents are incorporated herein by reference:<\/p>\n
\u00a0<\/p>\n
(a)The latest Registrant\u2019s Form 20-F filed with the Commission on March 04, 2025 (the \u201cForm 20-F\u201d) pursuant
\nto Section 13(a) or 15(d) of the Exchange Act (the \u201cExchange Act\u201d), which contains the Registrant\u2019s audited financial
\nstatements for the latest fiscal year for which such statements have been filed (File No. 001-40627);<\/p>\n
\u00a0<\/p>\n
(b)The Registrant\u2019s Current Report on Form 6-K, filed with the SEC on May 6, 2025 (other than Exhibit 99.3 thereto) (File No. 001-40627);
\nand<\/p>\n
\u00a0<\/p>\n
(c)The description of the Registrant\u2019s share capital which is included as Exhibit 2.1 to the Form 20-F, including any amendment
\nor supplements thereto.<\/p>\n
\u00a0<\/p>\n
In addition, all documents subsequently filed by the Registrant with
\nthe Commission pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective amendment
\nto this Registration Statement which indicates that all securities offered have been sold or which deregisters all securities then remaining
\nunsold, including any Reports of Foreign Private Issuers on Form 6-K submitted during such period (or portion thereof) that is identified
\nin such form as being incorporated by reference into this Registration Statement, shall be deemed to be incorporated by reference in this
\nRegistration Statement and to be a part hereof from the date of the filing of such documents. The Registrant is not incorporating by reference
\nany documents or portions thereof, whether specifically listed above or filed in the future, that are not deemed \u201cfiled\u201d with
\nthe Commission.<\/p>\n
\u00a0<\/p>\n
Any statement contained in a document incorporated or deemed to be
\nincorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent
\nthat a statement contained herein, (or in any other subsequently filed document which also is incorporated or deemed to be incorporated
\nby reference herein), modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except
\nas so modified or superseded, to constitute a part of this Registration Statement.<\/p>\n
\u00a0<\/p>\n
Item 8. Exhibits.<\/p>\n
\u00a0<\/p>\n
Exhibit Number<\/p>\n
\u00a0<\/p>\n
4
\n Amended Articles of Association of SOPHiA GENETICS SA (incorporated herein by reference to Exhibit 99.1 to the Registrant\u2019s Form 6-K, filed on June 18, 2025)<\/p>\n
\u00a0
\n \u00a0<\/p>\n
5
\n Opinion of Niederer Kraft Frey Ltd., Swiss counsel of SOPHiA GENETICS SA (filed herewith)<\/p>\n
\u00a0
\n \u00a0<\/p>\n
23.1
\n Consent of PricewaterhouseCoopers SA, independent registered public accounting firm (filed herewith)<\/p>\n
\u00a0
\n \u00a0<\/p>\n
23.2
\n Consent of Niederer Kraft Frey Ltd.,Swiss counsel of SOPHiA GENETICS SA (included in Exhibit 5)<\/p>\n
\u00a0
\n \u00a0<\/p>\n
24
\n Powers of Attorney (included in the signature pages hereto)<\/p>\n
\u00a0
\n \u00a0<\/p>\n
99.1
\n SOPHiA GENETICS SA 2021 Equity Incentive Plan (incorporated herein by reference to Exhibit 10.13 to the Registrant\u2019s Registration Statement on Form F-1, filed on July 2, 2021)<\/p>\n
\u00a0
\n \u00a0<\/p>\n
107
\n Filing Fee Table (filed herewith)<\/p>\n
\u00a0<\/p>\n
SIGNATURES<\/p>\n
\u00a0<\/p>\n
Pursuant to the requirements of the Securities
\nAct of 1933, as amended (the \u201cSecurities Act\u201d), the Registrant certifies that it has reasonable grounds to believe
\nthat it meets all of the requirements for filing this Registration Statement and has duly caused this Registration Statement to be signed
\non its behalf by the undersigned, thereunto duly authorized, in the municipality of Rolle, Switzerland on July 11,
\n2025.<\/p>\n
\u00a0<\/p>\n
\u00a0
\n SOPHiA GENETICS SA
\n \u00a0<\/p>\n
\u00a0
\n \u00a0
\n \u00a0<\/p>\n
\u00a0
\n \u00a0
\n \u00a0<\/p>\n
\u00a0
\n By:
\n \/s\/ Ross Muken
\n \u00a0<\/p>\n
\u00a0
\n Name:
\n Ross Muken
\n \u00a0<\/p>\n
\u00a0
\n Title:
\n President
\n \u00a0<\/p>\n
\u00a0<\/p>\n
POWER OF ATTORNEY<\/p>\n
\u00a0<\/p>\n
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature
\nappears below hereby constitutes and appoints Jurgi Camblong, Ross Muken and Daan van Well and each of them, individually, as his or her
\ntrue and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution, for him or her and in his or her name,
\nplace and stead, in any and all capacities, in connection with this registration statement, including to sign in the name and on behalf
\nof the undersigned, this Registration Statement and any and all amendments thereto, including post-effective amendments and registrations
\nfiled pursuant to Rule 462 under the Securities Act, as amended, and to file the same, with all exhibits thereto, and other documents
\nin connection therewith, with the U.S. Securities and Exchange Commission, granting unto each such attorney-in-fact and agent full power
\nand authority to do and perform each and every act in person, hereby ratifying and confirming all that each said attorney-in-fact and
\nagent, or his or her substitutes, may lawfully do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities
\nAct, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.<\/p>\n
\u00a0<\/p>\n
Signature
\n \u00a0
\n Title
\n Date<\/p>\n
\u00a0
\n \u00a0
\n \u00a0
\n \u00a0<\/p>\n
\/s\/ Jurgi Camblong
\n \u00a0
\n Chief Executive Officer and Director
\n July 11,
\n2025<\/p>\n
Jurgi Camblong
\n \u00a0
\n (Principal Executive Officer)
\n \u00a0<\/p>\n
\u00a0
\n \u00a0
\n \u00a0
\n \u00a0<\/p>\n
\/s\/ George Cardoza
\n \u00a0
\n Chief Financial Officer
\n July 11,
\n2025<\/p>\n
George Cardoza
\n \u00a0
\n (Principal Financial and Accounting Officer)
\n \u00a0<\/p>\n
\u00a0
\n \u00a0
\n \u00a0
\n \u00a0<\/p>\n
\/s\/ Troy Cox
\n \u00a0
\n \u00a0
\n July 11,
\n2025<\/p>\n
Troy Cox
\n \u00a0
\n Chairman of the Board of Directors
\n \u00a0<\/p>\n
\u00a0
\n \u00a0
\n \u00a0
\n \u00a0<\/p>\n
\/s\/ Tomer Berkovitz\u00a0
\n \u00a0
\n \u00a0
\n July 11,
\n2025<\/p>\n
Tomer Berkovitz
\n \u00a0
\n Director
\n \u00a0<\/p>\n
\u00a0
\n \u00a0
\n \u00a0
\n \u00a0<\/p>\n
\/s\/ Kathy Hibbs
\n \u00a0
\n \u00a0
\n July 11,
\n2025<\/p>\n
Kathy Hibbs
\n \u00a0
\n Director
\n \u00a0<\/p>\n
\u00a0
\n \u00a0
\n \u00a0
\n \u00a0<\/p>\n
\/s\/ Didier Hirsch
\n \u00a0
\n \u00a0
\n July 11,
\n2025<\/p>\n
Didier Hirsch
\n \u00a0
\n Director
\n \u00a0<\/p>\n
\u00a0
\n \u00a0
\n \u00a0
\n \u00a0<\/p>\n
\/s\/ Vincent Ossipow
\n \u00a0
\n \u00a0
\n July 11,
\n2025<\/p>\n
Vincent Ossipow
\n \u00a0
\n Director
\n \u00a0<\/p>\n
\u00a0
\n \u00a0
\n \u00a0
\n \u00a0<\/p>\n
\/s\/ Jean-Michel Coss\u00e9ry
\n \u00a0
\n \u00a0
\n July 11,
\n2025<\/p>\n
Jean-Michel Coss\u00e9ry
\n \u00a0
\n Director
\n \u00a0<\/p>\n
\u00a0
\n \u00a0
\n \u00a0
\n \u00a0<\/p>\n
\/s\/ Ross Muken
\n \u00a0
\n \u00a0
\n July 11,
\n2025<\/p>\n
Ross Muken
\n \u00a0
\n President, Authorized Representative in the United States
\n \u00a0<\/p>\n
\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"\u00a0 As filed with the Securities and Exchange Commission on July 11, 2025 \u00a0 Registration No. 333-__________ \u00a0…\n","protected":false},"author":2,"featured_media":3491,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[50],"tags":[4071,4069,4070,4068,200,4072,4066,4065,4067,79],"class_list":{"0":"post-3490","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-genetics","8":"tag-5m-divestiture","9":"tag-debt-reduction","10":"tag-form-8-k","11":"tag-fortman-sale","12":"tag-genetics","13":"tag-interest-savings","14":"tag-reli","15":"tag-reliance-global-group","16":"tag-reliw","17":"tag-science"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/3490","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/comments?post=3490"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/3490\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media\/3491"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media?parent=3490"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/categories?post=3490"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/tags?post=3490"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}