U.S. regulators on Monday gave the green light to a pill version of the blockbuster weight-loss drug Wegovy, the first daily oral medication to treat obesity.<\/p>\n
The U.S. Food and Drug Administration\u2019s approval handed drugmaker Novo Nordisk an edge over rival Eli Lilly in the race to market an obesity pill. Lilly\u2019s oral drug, orforglipron, is still under review.<\/p>\n
The pill will be produced in North Carolina.<\/p>\n
\u201cWe have a strong, reliable supply of Wegovy pill,” said Dave Moore, executive vice president of the company’s US Operations. “We planned ahead, and over the years have made significant multi-billion dollar investments in building production capacity. The active ingredient in Wegovy pill will be produced from end-to-end in North Carolina \u2013 made by Americans for Americans. We are confident and ready to meet demand so patients can count on timely access to Wegovy pill.\u201d<\/p>\n
Both pills are GLP-1 drugs that work like widely used injectables to mimic a natural hormone that controls appetite and feelings of fullness.<\/p>\n
In recent years, Novo Nordisk\u2019s injectable Wegovy and Lilly\u2019s Zepbound have revolutionized obesity treatment globally and in the U.S., where 100 million people have the chronic disease.<\/p>\n
The Wegovy pills are expected to be available within weeks, company officials said. Availability of oral pills to treat obesity could expand the booming market for obesity treatments by broadening access and reducing costs, experts said. <\/p>\n
About 1 in 8 Americans have used injectable GLP-1 drugs, according to a survey from KFF, a nonprofit health policy research group. But many more have trouble affording the costly shots.<\/p>\n
\u201cThere\u2019s an entire demographic that can benefit from the pills,\u201d said Dr. Fatima Cody Stanford, a Massachusetts General Hospital obesity expert. \u201cFor me, it\u2019s not just about who gets it across the finish line first. It\u2019s about having these options available to patients.\u201d<\/p>\n
The Novo Nordisk obesity pill contains 25 milligrams of semaglutide. That’s the same ingredient in injectables Wegovy and Ozempic and in Rybelsus, a lower-dose pill approved to treat diabetes in 2019.<\/p>\n
In a clinical trial, participants who took oral Wegovy lost 13.6% of their total body weight on average over about 15 months, compared with a 2.2% loss if they took a placebo, or dummy pill. That\u2019s nearly the same as injectable Wegovy, with an average weight loss of about 15%.<\/p>\n
Chris Mertens, 35, a pediatric lung doctor in Menomonee Falls, Wisconsin, joined the Novo Nordisk trial in 2022 and lost about 40 pounds using the Wegovy pill. The daily medication worked to decrease his appetite and invasive thoughts of food, he said. <\/p>\n
\u201cIf there were days where I missed a meal, I almost didn\u2019t realize it,\u201d Mertens said.<\/p>\n
Participants in a clinical trial who took the highest dose of Lilly\u2019s orforglipron lost 11.2% of their total body weight on average over nearly 17 months, compared with a 2.1% loss in those who took a placebo.<\/p>\n
Both pills resulted in less weight loss than the average achieved with Lilly\u2019s Zepbound, or tirzepatide, which targets two gut hormones, GLP-1 and GIP, and led to a 21% average weight loss.<\/p>\n
All the GLP-1 drugs, oral or injectable, have similar side effects, including nausea and diarrhea.<\/p>\n
Both daily pills promise convenience, but the Wegovy pill must be taken with a sip of water in the morning on an empty stomach, with a 30-minute break before eating or drinking.<\/p>\n
That\u2019s because Novo Nordisk had to design the pill in a way that prevented the drug from being broken down in the stomach before it could be absorbed by the bloodstream. The drugmaker added an ingredient that protects the medication for about 30 minutes in the gut and makes it easier to take effect.<\/p>\n
By contrast, Lilly\u2019s orforglipron has no dosing restrictions. That drug is being considered under the FDA\u2019s new priority voucher program aimed at cutting drug approval times. A decision is expected by spring.<\/p>\n
Producing pills is generally cheaper than making drugs delivered via injections, so the cost for the new oral medications could be lower. The Trump administration earlier this year said officials had worked with drugmakers to negotiate lower prices for the GLP-1 drugs, which can cost upwards of $1,000 a month.<\/p>\n
The company said the starting dose would be available for $149 per month from some providers. Additional information on cost will be available in January.<\/p>\n
It\u2019s not clear whether daily pills or weekly injections will be preferred by patients. Although some patients dislike needles, others don’t seem to mind the weekly injections, obesity experts said. Mertens turned to injectable Zepbound when he regained weight after the end of the Wegovy pill clinical trial.<\/p>\n
He said he liked the discipline of the daily pill.<\/p>\n
\u201cIt was a little bit of an intentional routine and a reminder of today I\u2019m taking this so that I know my choices are going to be affected for the day,\u201d he said.<\/p>\n
Dr. Angela Fitch, an obesity expert and chief medical officer of knownwell, a health care company, said whatever the format, the biggest benefit will be in making weight-loss medications more widely accessible and affordable.<\/p>\n
\u201cIt\u2019s all about the price,\u201d she said. \u201cJust give me a drug at $100 a month that is relatively effective.\u201d<\/p>\n
___ <\/p>\n
The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute\u2019s Department of Science Education and the Robert Wood Johnson Foundation. The AP is solely responsible for all content.<\/p>\n","protected":false},"excerpt":{"rendered":"U.S. regulators on Monday gave the green light to a pill version of the blockbuster weight-loss drug Wegovy,…\n","protected":false},"author":2,"featured_media":375785,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[58],"tags":[153360,179403,2724,97,243],"class_list":["post-375784","post","type-post","status-publish","format-standard","has-post-thumbnail","category-medication","tag-ap-business","tag-ap-health","tag-associated-press","tag-health","tag-medication"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/375784","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/comments?post=375784"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/375784\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media\/375785"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media?parent=375784"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/categories?post=375784"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/tags?post=375784"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}