{"id":443556,"date":"2026-02-01T22:02:36","date_gmt":"2026-02-01T22:02:36","guid":{"rendered":"https:\/\/www.newsbeep.com\/us\/443556\/"},"modified":"2026-02-01T22:02:36","modified_gmt":"2026-02-01T22:02:36","slug":"the-environmental-exposome-in-heart-failure-risk-and-progression","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/us\/443556\/","title":{"rendered":"The environmental exposome in heart failure risk and progression"},"content":{"rendered":"

Ran, J. et al. Global, regional, and national burden of heart failure and its underlying causes, 1990\u20132021: results from the global burden of disease study 2021. Biomark. Res. 13, 16 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Al-Kindi, S. G., Brook, R. D., Biswal, S. & Rajagopalan, S. Environmental determinants of cardiovascular disease: lessons learned from air pollution. Nat. Rev. Cardiol. 17, 656\u2013672 (2020).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Chatterjee, N., Gim, J. & Choi, J. Epigenetic profiling to environmental stressors in model and non-model organisms: ecotoxicology perspective. Environ. Health Toxicol. 33, e2018015 (2018).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Hala, D., Huggett, D. & Burggren, W. Environmental stressors and the epigenome. Drug Discov. Today Technol. 12, e3\u2013e8 (2014).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Perera, F. & Herbstman, J. Prenatal environmental exposures, epigenetics, and disease. Reprod. Toxicol. 31, 363\u2013373 (2011).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wild, C. P. Complementing the genome with an \u201cexposome\u201d: the outstanding challenge of environmental exposure measurement in molecular epidemiology. Cancer Epidemiol. Biomarkers Prev. 14, 1847\u20131850 (2005).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Daiber, A. et al. The \u201cexposome\u201d concept \u2014 how environmental risk factors influence cardiovascular health. Acta Biochim. Pol. 66, 269\u2013283 (2019).<\/p>\n

CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

M\u00fcnzel, T., S\u00f8rensen, M., Hahad, O., Nieuwenhuijsen, M. & Daiber, A. The contribution of the exposome to the burden of cardiovascular disease. Nat. Rev. Cardiol. 20, 651\u2013669 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Khraishah, H., Chen, Z. & Rajagopalan, S. Understanding the cardiovascular and metabolic health effects of air pollution in the context of cumulative exposomic impacts. Circ. Res. 134, 1083\u20131097 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Rajagopalan, S., Al-Kindi, S. G. & Brook, R. D. Air pollution and cardiovascular disease: JACC state-of-the-art review. J. Am. Coll. Cardiol. 72, 2054\u20132070 (2018).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Khraishah, H. et al. Climate change and cardiovascular disease: implications for global health. Nat. Rev. Cardiol. 19, 798\u2013812 (2022).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

M\u00fcnzel, T. et al. Environmental noise and the cardiovascular system. J. Am. Coll. Cardiol. 71, 688\u2013697 (2018).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zielinska-Dabkowska, K. M., Schernhammer, E. S., Hanifin, J. P. & Brainard, G. C. Reducing nighttime light exposure in the urban environment to benefit human health and society. Science 380, 1130\u20131135 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Martinez-Morata, I. et al. Associations between urinary metal levels and incident heart failure: a multi-cohort analysis. JACC Heart Fail. 13, 102510 (2025).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Lamas, G. A. et al. Contaminant metals as cardiovascular risk factors: a scientific statement from the American Heart Association. J. Am. Heart Assoc. 12, e029852 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Hahad, O., Al-Kindi, S., Lelieveld, J., M\u00fcnzel, T. & Daiber, A. Supporting and implementing the beneficial parts of the exposome: the environment can be the problem, but it can also be the solution. Int. J. Hyg. Environ. Health 255, 114290 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zhang, K., Brook, R. D., Li, Y., Rajagopalan, S. & Kim, J. B. Air pollution, built environment, and early cardiovascular disease. Circ. Res. 132, 1707\u20131724 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Rajagopalan, S. et al. The urban environment and cardiometabolic health. Circulation 149, 1298\u20131314 (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ji, L.-D., Tang, N. L. S., Xu, Z. F. & Xu, J. Genes regulate blood pressure, but \u201cenvironments\u201d cause hypertension. Front. Genet. 11, 580443 (2020).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

\u00d8vretveit, K. et al. Polygenic interactions with environmental exposures in blood pressure regulation: the HUNT study. J. Am. Heart Assoc. 13, e034612 (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Keaton, J. M. et al. Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits. Nat. Genet. 56, 778\u2013791 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Pazoki, R. et al. Genetic predisposition to high blood pressure and lifestyle factors: associations with midlife blood pressure levels and cardiovascular events. Circulation 137, 653\u2013661 (2018).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wu, H., Eckhardt, C. M. & Baccarelli, A. A. Molecular mechanisms of environmental exposures and human disease. Nat. Rev. Genet. 24, 332\u2013344 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Baccarelli, A., Dolinoy, D. C. & Walker, C. L. A precision environmental health approach to prevention of human disease. Nat. Commun. 14, 2449 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Tanwar, V. et al. PM2.5 exposure in utero contributes to neonatal cardiac dysfunction in mice. Environ. Pollut. 230, 116\u2013124 (2017).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Tanwar, V. et al. In utero particulate matter exposure produces heart failure, electrical remodeling, and epigenetic changes at adulthood. J. Am. Heart Assoc. 6, e005796 (2017).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ho, F. K. et al. A proteomics-based approach for prediction of different cardiovascular diseases and dementia. Circulation 151, 277\u2013287 (2025).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Government of Canada. Human Health Risk Assessment for Ambient Nitrogen Dioxide https:\/\/www.canada.ca\/en\/health-canada\/services\/publications\/healthy-living\/human-health-risk-assessment-ambient-nitrogen-dioxide.html<\/a> (2016).<\/p>\n

Public Health England. Associations of Long-term Average Concentrations of Nitrogen Dioxide with Mortality (2018): COMEAP Summary https:\/\/www.gov.uk\/government\/publications\/nitrogen-dioxide-effects-on-mortality\/associations-of-long-term-average-concentrations-of-nitrogen-dioxide-with-mortality-2018-comeap-summary<\/a> (2018).<\/p>\n

United States Environmental Protection Agency. Integrated Science Assessment (ISA) for Oxides of Nitrogen \u2013 Health Criteria (Final Report, Jan 2016) https:\/\/cfpub.epa.gov\/ncea\/isa\/recordisplay.cfm?deid=310879<\/a> (2016).<\/p>\n

Thurston, G. D. et al. Ischemic heart disease mortality and long-term exposure to source-related components of U.S. fine particle air pollution. Env. Health Perspect. 124, 785\u2013794 (2016).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Eminson, K. et al. Does air pollution confound associations between environmental noise and cardiovascular outcomes? \u2014 A systematic review. Env. Res. 232, 116075 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Rajagopalan, S. & Landrigan, P. J. Pollution and the heart. N. Engl. J. Med. 385, 1881\u20131892 (2021).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Abohashem, S. et al. A leucopoietic-arterial axis underlying the link between ambient air pollution and cardiovascular disease in humans. Eur. Heart J. 42, 761\u2013772 (2021).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kuntic, M. et al. Differential inflammation, oxidative stress and cardiovascular damage markers of nano- and micro-particle exposure in mice: implications for human disease burden. Redox Biol. 83, 103644 (2025).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wold, L. E. et al. Cardiovascular remodeling in response to long-term exposure to fine particulate matter air pollution. Circ. Heart Fail. 5, 452\u2013461 (2012).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Liu, Q. et al. Potential molecular mechanism of cardiac hypertrophy in mice induced by exposure to ambient PM2. 5. Ecotoxicol. Environ. Saf. 224, 112659 (2021).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wu, T. et al. PM2.5-induced programmed myocardial cell death via mPTP opening results in deteriorated cardiac function in HFpEF mice. Cardiovasc. Toxicol. 22, 746\u2013762 (2022).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Mills, N. L. et al. Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease. N. Engl. J. Med. 357, 1075\u20131082 (2007).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Langrish, J. P. et al. Altered nitric oxide bioavailability contributes to diesel exhaust inhalation-induced cardiovascular dysfunction in man. J. Am. Heart Assoc. 2, e004309 (2013).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Lucking, A. J. et al. Particle traps prevent adverse vascular and prothrombotic effects of diesel engine exhaust inhalation in men. Circulation 123, 1721\u20131728 (2011).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Shah, A. S. et al. Global association of air pollution and heart failure: a systematic review and meta-analysis. Lancet 382, 1039\u20131048 (2013).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Jia, Y. et al. Effect of air pollution on heart failure: systematic review and meta-analysis. Env. Health Perspect. 131, 76001 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wang, M. et al. Joint exposure to various ambient air pollutants and incident heart failure: a prospective analysis in UK Biobank. Eur. Heart J. 42, 1582\u20131591 (2021).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Bai, L. et al. Exposure to ambient air pollution and the incidence of congestive heart failure and acute myocardial infarction: a population-based study of 5.1 million Canadian adults living in Ontario. Env. Int. 132, 105004 (2019).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ward-Caviness, C. K. et al. Long-term exposure to particulate air pollution is associated with 30-day readmissions and hospital visits among patients with heart failure. J. Am. Heart Assoc. 10, e019430 (2021).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Mentias, A. et al. Ambient air pollution exposure and adverse outcomes among medicare beneficiaries with heart failure. J. Am. Heart Assoc. 13, e032902 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Al-Kindi, S. G. et al. Ambient air pollution and mortality after cardiac transplantation. J. Am. Coll. Cardiology 74, 3026\u20133035 (2019).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Vieira, J. L. et al. Respiratory filter reduces the cardiovascular effects associated with diesel exhaust exposure: a randomized, prospective, double-blind, controlled study of heart failure: the FILTER-HF trial. JACC Heart Fail. 4, 55\u201364 (2016).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Vieira, J. L., Guimaraes, G. V., de Andre, P. A., Saldiva, P. H. & Bocchi, E. A. Effects of reducing exposure to air pollution on submaximal cardiopulmonary test in patients with heart failure: analysis of the randomized, double-blind and controlled FILTER-HF trial. Int. J. Cardiol. 215, 92\u201397 (2016).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Rajagopalan, S. et al. Toward heart-healthy and sustainable cities: a policy statement from the American Heart Association. Circulation 149, e1067\u2013e1089 (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Hahad, O. et al. Noise and air pollution as risk factors for hypertension: part. I-epidemiology. Hypertension 80, 1375\u20131383 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Hahad, O. et al. Noise and air pollution as risk factors for hypertension: part. II-pathophysiologic insight. Hypertension 80, 1384\u20131392 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

M\u00fcnzel, T., S\u00f8rensen, M. & Daiber, A. Transportation noise pollution and cardiovascular disease. Nat. Rev. Cardiol 18, 619\u2013636 (2021).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Hahad, O. et al. Cerebral consequences of environmental noise exposure. Environ. Int. 165, 107306 (2022).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Fu, X. et al. Long-term exposure to traffic noise and risk of incident cardiovascular diseases: a systematic review and dose-response meta-analysis. J. Urban Health 100, 788\u2013801 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Heritier, H. et al. Transportation noise exposure and cardiovascular mortality: a nationwide cohort study from Switzerland. Eur. J. Epidemiol. 32, 307\u2013315 (2017).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Vienneau, D. et al. Transportation noise exposure and cardiovascular mortality: 15-years of follow-up in a nationwide prospective cohort in Switzerland. Env. Int. 158, 106974 (2022).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Thacher, J. D. et al. Exposure to transportation noise and risk for cardiovascular disease in a nationwide cohort study from Denmark. Env. Res. 211, 113106 (2022).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Yang, T. et al. Long-term exposure to road traffic noise and incident heart failure: evidence from UK Biobank. JACC Heart Fail. 11, 986\u2013996 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Seidler, A. et al. Aircraft, road and railway traffic noise as risk factors for heart failure and hypertensive heart disease \u2014 a case-control study based on secondary data. Int. J. Hyg. Env. Health 219, 749\u2013758 (2016).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Bai, L. et al. Exposure to road traffic noise and incidence of acute myocardial infarction and congestive heart failure: a population-based cohort study in Toronto, Canada. Env. Health Perspect. 128, 87001 (2020).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Topriceanu, C. C. et al. Higher aircraft noise exposure is linked to worse heart structure and function by cardiovascular MRI. J. Am. Coll. Cardiol. 85, 454\u2013469 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Davies, H. W., Vlaanderen, J. J., Henderson, S. B. & Brauer, M. Correlation between co-exposures to noise and air pollution from traffic sources. Occup. Env. Med. 66, 347\u2013350 (2009).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Gale, J. E. et al. Disruption of circadian rhythms accelerates development of diabetes through pancreatic beta-cell loss and dysfunction. J. Biol. Rhythm. 26, 423\u2013433 (2011).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kurose, T., Yabe, D. & Inagaki, N. Circadian rhythms and diabetes. J. Diabetes Investig. 2, 176\u2013177 (2011).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Qian, J., Yeh, B., Rakshit, K., Colwell, C. S. & Matveyenko, A. V. Circadian disruption and diet-induced obesity synergize to promote development of beta-cell failure and diabetes in male rats. Endocrinology 156, 4426\u20134436 (2015).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Gamble, K. L., Berry, R., Frank, S. J. & Young, M. E. Circadian clock control of endocrine factors. Nat. Rev. Endocrinol. 10, 466\u2013475 (2014).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Stenvers, D. J., Scheer, F., Schrauwen, P., la Fleur, S. E. & Kalsbeek, A. Circadian clocks and insulin resistance. Nat. Rev. Endocrinol. 15, 75\u201389 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Cribbet, M. R. et al. Circadian rhythms and metabolism: from the brain to the gut and back again. Ann. N. Y. Acad. Sci. 1385, 21\u201340 (2016).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Masri, S. & Sassone-Corsi, P. The circadian clock: a framework linking metabolism, epigenetics and neuronal function. Nat. Rev. Neurosci. 14, 69\u201375 (2013).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Masri, S., Zocchi, L., Katada, S., Mora, E. & Sassone-Corsi, P. The circadian clock transcriptional complex: metabolic feedback intersects with epigenetic control. Ann. N. Y. Acad. Sci. 1264, 103\u2013109 (2012).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Patel, V. R., Eckel-Mahan, K., Sassone-Corsi, P. & Baldi, P. CircadiOmics: integrating circadian genomics, transcriptomics, proteomics and metabolomics. Nat. Methods 9, 772\u2013773 (2012).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zubidat, A. E. & Haim, A. Artificial light-at-night \u2014 a novel lifestyle risk factor for metabolic disorder and cancer morbidity. J. Basic Clin. Physiol. Pharmacol. 28, 295\u2013313 (2017).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Palanivel, R. et al. Exposure to air pollution disrupts circadian rhythm through alterations in chromatin dynamics. iScience 23, 101728 (2020).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Xu, C. et al. Shift work, genetic factors, and the risk of heart failure: a prospective study of the UK biobank. Mayo Clin. Proc. 97, 1134\u20131144 (2022).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Li, X., He, Y., Wang, D. & Momeni, M. R. Chronobiological disruptions: unravelling the interplay of shift work, circadian rhythms, and vascular health in the context of stroke risk. Clin. Exp. Med. 25, 6 (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Lane, K. J. et al. Associations between greenness, impervious surface area, and nighttime lights on biomarkers of vascular aging in Chennai, India. Env. Health Perspect. 125, 087003 (2017).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zhang, J. et al. Role of nighttime light in the association between air pollution exposure and cardiovascular disease. J. Am. Heart Assoc. 14, e042835 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Liang, X. et al. Outdoor light at night and mortality in the UK Biobank: a prospective cohort study. Occup. Env. Med. https:\/\/doi.org\/10.1136\/oemed-2023-109036<\/a> (2023).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Martinez-Morata, I. et al. Association of urinary metals with cardiovascular disease incidence and all-cause mortality in the multi-ethnic study of atherosclerosis (MESA). Circulation 150, 758\u2013769 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

McGraw, K. E. et al. Urinary metal levels and coronary artery calcification: longitudinal evidence in the multi-ethnic study of atherosclerosis. J. Am. Coll. Cardiol. 84, 1545\u20131557 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Paithankar, J. G., Saini, S., Dwivedi, S., Sharma, A. & Chowdhuri, D. K. Heavy metal associated health hazards: an interplay of oxidative stress and signal transduction. Chemosphere 262, 128350 (2021).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Borne, Y. et al. Cadmium exposure and incidence of heart failure and atrial fibrillation: a population-based prospective cohort study. BMJ Open 5, e007366 (2015).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Peters, J. L., Perlstein, T. S., Perry, M. J., McNeely, E. & Weuve, J. Cadmium exposure in association with history of stroke and heart failure. Env. Res. 110, 199\u2013206 (2010).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Vaziri, N. D. Mechanisms of lead-induced hypertension and cardiovascular disease. Am. J. Physiol. Heart Circ. Physiology 295, H454\u2013H465 (2008).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Navas-Acien, A., Guallar, E., Silbergeld, E. K. & Rothenberg, S. J. Lead exposure and cardiovascular disease \u2014 a systematic review. Env. Health Perspect. 115, 472\u2013482 (2007).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Yang, W. Y. et al. Left ventricular structure and function in relation to environmental exposure to lead and cadmium. J. Am. Heart Assoc. 6, e004692 (2017).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Bello, K. A. et al. Chronic exposure to mercury increases arrhythmia and mortality post-acute myocardial infarction in rats. Front. Physiol. 14, 1260509 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Xing, X. et al. Association of selenium and cadmium with heart failure and mortality based on the National Health and Nutrition Examination Survey. J. Hum. Nutr. Diet. 36, 1496\u20131506 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Sears, C. G. et al. Urinary cadmium and incident heart failure: a case-cohort analysis among never-smokers in Denmark. Epidemiology 33, 185\u2013192 (2022).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Lieberman-Cribbin, W. et al. Relationship between urinary uranium and cardiac geometry and left ventricular function: the Strong Heart study. JACC Adv. 3, 101408 (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Pichler, G. et al. Association of arsenic exposure with cardiac geometry and left ventricular function in young adults. Circ. Cardiovasc. Imaging 12, e009018 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

George, C. M. et al. Effect of an arsenic mitigation program on arsenic exposure in American Indian communities: a cluster randomized controlled trial of the community-led Strong Heart Water Study program. Env. Health Perspect. 132, 37007 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Lamas, G. A. et al. Edetate disodium-based chelation for patients with a previous myocardial infarction and diabetes: TACT2 randomized clinical trial. JAMA 332, 794\u2013803 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ravalli, F. et al. Chelation therapy in patients with cardiovascular disease: a systematic review. J. Am. Heart Assoc. 11, e024648 (2022).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Chowdhury, R. et al. Environmental toxic metal contaminants and risk of cardiovascular disease: systematic review and meta-analysis. BMJ 362, k3310 (2018).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Alahmad, B. et al. Associations between extreme temperatures and cardiovascular cause-specific mortality: results from 27 countries. Circulation 147, 35\u201346 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Achebak, H. et al. Ambient temperature and risk of cardiovascular and respiratory adverse health outcomes: a nationwide cross-sectional study from Spain. Eur. J. Prev. Cardiol. 31, 1080\u20131089 (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Singh, N. et al. Heat and cardiovascular mortality: an epidemiological perspective. Circ. Res. 134, 1098\u20131112 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

de Schrijver, E. et al. Nationwide projections of heat- and cold-related mortality impacts under various climate change and population development scenarios in Switzerland. Env. Res. Lett. 18, 094010 (2023).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Mugele, H. et al. Control of blood pressure in the cold: differentiation of skin and skeletal muscle vascular resistance. Exp. Physiol. 108, 38\u201349 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kim, J. & Kim, H. Influence of ambient temperature and diurnal temperature range on incidence of cardiac arrhythmias. Int. J. Biometeorol. 61, 407\u2013416 (2017).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Meade, R. D. et al. Meta-analysis of heat-induced changes in cardiac function from over 400 laboratory-based heat exposure studies. Nat. Commun. 16, 2543 (2025).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Cui, J. et al. Effects of heat stress on thermoregulatory responses in congestive heart failure patients. Circulation 112, 2286\u20132292 (2005).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Green, D. J. et al. Impaired skin blood flow response to environmental heating in chronic heart failure. Eur. Heart J. 27, 338\u2013343 (2006).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wilker, E. H. et al. Ambient temperature and biomarkers of heart failure: a repeated measures analysis. Env. Health Perspect. 120, 1083\u20131087 (2012).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Qiu, H. et al. Is greater temperature change within a day associated with increased emergency hospital admissions for heart failure? Circ. Heart Fail. 6, 930\u2013935 (2013).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Pan, R. et al. Association between ambient temperature and cause-specific cardiovascular disease admissions in Japan: a nationwide study. Env. Res. 225, 115610 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Jimba, T. et al. Association of ambient temperature and acute heart failure with preserved and reduced ejection fraction. ESC Heart Fail. 9, 2899\u20132908 (2022).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Munzel, T. et al. Challenges posed by climate hazards to cardiovascular health and cardiac intensive care: implications for mitigation and adaptation. Eur. Heart J. Acute Cardiovasc. Care 13, 731\u2013744 (2024).<\/p>\n

PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Vishram-Nielsen, J. K. et al. Association between the incidence of hospitalizations for acute cardiovascular events, weather, and air pollution. JACC Adv. 2, 100334 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Shih, H.-I. et al. Increased medical visits and mortality among adults with cardiovascular diseases in severely affected areas after Typhoon Morakot. Int. J. Environ. Res. Public Health 17, 6531 (2020).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Yan, M. et al. Tropical cyclone exposures and risks of emergency medicare hospital admission for cardiorespiratory diseases in 175 urban United States counties, 1999\u20132010. Epidemiology 32, 315\u2013326 (2021).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Danesh Yazdi, M. et al. The effect of long-term exposure to air pollution and seasonal temperature on hospital admissions with cardiovascular and respiratory disease in the United States: a difference-in-differences analysis. Sci. Total. Env. 843, 156855 (2022).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Nieuwenhuijsen, M. J. Green infrastructure and health. Annu. Rev. Public Health 42, 317\u2013328 (2021).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Pereira, G. et al. The association between neighborhood greenness and cardiovascular disease: an observational study. BMC Public Health 12, 466 (2012).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Yeager, R. et al. Association between residential greenness and cardiovascular disease risk. J. Am. Heart Assoc. 7, e009117 (2018).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Dazard, J. E. et al. Association of genetic variants with modifiable environmental factor in cardiovascular disease risk: a UK Biobank Mendelian randomization study. J. Am. Coll. Cardiol 85, a331 (2025).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Iyer, H. S. et al. Impact of neighborhood socioeconomic status, income segregation, and greenness on blood biomarkers of inflammation. Env. Int. 162, 107164 (2022).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wang, K. et al. Relationship of neighborhood greenness to heart disease in 249 405 US medicare beneficiaries. J. Am. Heart Assoc. 8, e010258 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Liu, T. et al. Association of neighborhood greenness exposure with cardiovascular diseases and biomarkers. Int. J. Hyg. Env. Health 234, 113738 (2021).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Chen, H. et al. Residential greenness and cardiovascular disease incidence, readmission, and mortality. Env. Health Perspect. 128, 87005 (2020).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Poulsen, A. H. et al. Concomitant exposure to air pollution, green space, and noise and risk of stroke: a cohort study from Denmark. Lancet Reg. Health Eur. 31, 100655 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Mukhopadhyay, A. et al. Neighborhood-level socioeconomic status and prescription fill patterns among patients with heart failure. JAMA Netw. Open 6, e2347519 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kowaleski-Jones, L. et al. Walkable neighborhoods and obesity: evaluating effects with a propensity score approach. SSM Popul. Health 6, 9\u201315 (2017).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Son, W. H., Park, H. T., Jeon, B. H. & Ha, M. S. Moderate intensity walking exercises reduce the body mass index and vascular inflammatory factors in postmenopausal women with obesity: a randomized controlled trial. Sci. Rep. 13, 20172 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Yamamoto, Y. et al. Association between subjective walking speed and metabolic diseases in individuals with obesity: a cross-sectional analysis. Sci. Rep. 14, 28228 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Drexel, H. et al. Downhill hiking improves low-grade inflammation, triglycerides, body weight and glucose tolerance. Sci. Rep. 11, 14503 (2021).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Marshall, J. D., Brauer, M. & Frank, L. D. Healthy neighborhoods: walkability and air pollution. Environ. Health Perspect. 117, 1752\u20131759 (2009).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Howell, N. A., Tu, J. V., Moineddin, R., Chu, A. & Booth, G. L. Association between neighborhood walkability and predicted 10-year cardiovascular disease risk: the CANHEART (Cardiovascular Health in Ambulatory Care Research Team) cohort. J. Am. Heart Assoc. 8, e013146 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Gorczyca, A. M. et al. Change in physical activity and sitting time after myocardial infarction and mortality among postmenopausal women in the Women\u2019s Health Initiative-Observational study. J. Am. Heart Assoc. 6, e005354 (2017).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

James, P. et al. Interrelationships between walkability, air pollution, greenness, and body mass index. Epidemiology 28, 780\u2013788 (2017).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Appleton, A. A., Holdsworth, E. A. & Kubzansky, L. D. A systematic review of the interplay between social determinants and environmental exposures for early-life outcomes. Curr. Environ. Health Rep. 3, 287\u2013301 (2016).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Motairek, I., Chen, Z., Makhlouf, M. H., Rajagopalan, S. & Al-Kindi, S. Historical neighbourhood redlining and contemporary environmental racism. Local. Environ. 28, 518\u2013528 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Al-Kindi, S. et al. Historical neighborhood redlining and cardiovascular risk in patients with chronic kidney disease. Circulation 148, 280\u2013282 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Mentias, A. et al. Historical redlining, socioeconomic distress, and risk of heart failure among medicare beneficiaries. Circulation 148, 210\u2013219 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Fields, N. D. et al. Historical redlining and heart failure outcomes following hospitalization in the Southeastern United States. J. Am. Heart Assoc. 13, e032019 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Calvillo-King, L. et al. Impact of social factors on risk of readmission or mortality in pneumonia and heart failure: systematic review. J. Gen. Intern. Med. 28, 269\u2013282 (2013).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Hood, E. Dwelling disparities: how poor housing leads to poor health. Env. Health Perspect. 113, A310\u2013A317 (2005).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zuluaga, M. C. et al. Housing conditions and mortality in older patients hospitalized for heart failure. Am. Heart J. 161, 950\u2013955 (2011).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Abohashem, S. et al. Additive effect of high transportation noise exposure and socioeconomic deprivation on stress-associated neural activity, atherosclerotic inflammation, and cardiovascular disease events. J. Expo. Sci. Env. Epidemiol. 35, 62\u201369 (2025).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Dewan, P. et al. Income inequality and outcomes in heart failure: a global between-country analysis. JACC Heart Fail. 7, 336\u2013346 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Tromp, J. et al. Post-discharge prognosis of patients admitted to hospital for heart failure by world region, and national level of income and income disparity (REPORT-HF): a cohort study. Lancet Glob. Health 8, e411\u2013e422 (2020).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Hahad, O. et al. Exposomic determinants of atherosclerosis: recent evidence. Curr. Atheroscler. Rep. 27, 28 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Osborne, M. T. et al. The combined effect of air and transportation noise pollution on atherosclerotic inflammation and risk of cardiovascular disease events. J. Nucl. Cardiol. 30, 665\u2013679 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Al-Kindi, S. Leveraging geospatial data science to uncover novel environmental predictors of cardiovascular disease. JACC Adv. 2, 100371 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ibrahim, R. et al. Big data, big insights: leveraging data analytics to unravel cardiovascular exposome complexities. Methodist. Debakey Cardiovasc. J. 20, 111\u2013123 (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Felker, G. M. & Teerlink, J. R. in Braunwald\u2019s Heart Disease: A Textbook of Cardiovascular Medicine 12th edn Ch. 49 (eds Libby, P. et al.) 946\u2013974 (Elsevier, 2022).<\/p>\n

Zacharias, M., Al-Kindi, S. & Rajagopalan, S. Isolating noise from signals in the air. JACC Heart Fail. 11, 997\u2013999 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Hahad, O. & Al-Kindi, S. Heavy metal, heavy heart: adverse cardiovascular effects of uranium exposure. JACC Adv. 3, 101404 (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Bozkurt, B. et al. HF STATS 2024: heart failure epidemiology and outcomes statistics an updated 2024 report from the Heart Failure Society of America. J. Card. Fail. 31, 66\u2013116 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Cho, Y. et al. Effects of artificial light at night on human health: a literature review of observational and experimental studies applied to exposure assessment. Chronobiol. Int. 32, 1294\u20131310 (2015).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Dar, T. et al. Psychosocial stress and cardiovascular disease. Curr. Treat. Options Cardiovasc. Med. 21, 23 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n","protected":false},"excerpt":{"rendered":"Ran, J. et al. Global, regional, and national burden of heart failure and its underlying causes, 1990\u20132021: results…\n","protected":false},"author":2,"featured_media":443557,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[14298,8694,14297,192,257,19301,256,14296,79],"class_list":{"0":"post-443556","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-environment","8":"tag-cardiac-imaging","9":"tag-cardiac-surgery","10":"tag-cardiology","11":"tag-environment","12":"tag-general","13":"tag-heart-failure","14":"tag-medicine-public-health","15":"tag-risk-factors","16":"tag-science"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/443556","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/comments?post=443556"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/443556\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media\/443557"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media?parent=443556"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/categories?post=443556"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/tags?post=443556"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}