{"id":547409,"date":"2026-03-27T00:28:23","date_gmt":"2026-03-27T00:28:23","guid":{"rendered":"https:\/\/www.newsbeep.com\/us\/547409\/"},"modified":"2026-03-27T00:28:23","modified_gmt":"2026-03-27T00:28:23","slug":"structural-basis-of-supercoiling-induced-crispr-cas9-off-target-activity","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/us\/547409\/","title":{"rendered":"Structural basis of supercoiling-induced CRISPR\u2013Cas9 off-target activity"},"content":{"rendered":"<p class=\"c-article-references__text\" id=\"ref-CR1\">Pacesa, M., Pelea, O. &amp; Jinek, M. Past, present, and future of CRISPR genome editing technologies. 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