{"id":610839,"date":"2026-04-28T07:46:11","date_gmt":"2026-04-28T07:46:11","guid":{"rendered":"https:\/\/www.newsbeep.com\/us\/610839\/"},"modified":"2026-04-28T07:46:11","modified_gmt":"2026-04-28T07:46:11","slug":"scientists-discover-molecular-switch-that-fuels-alzheimers-brain-inflammation","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/us\/610839\/","title":{"rendered":"Scientists Discover \u201cMolecular Switch\u201d That Fuels Alzheimer\u2019s Brain Inflammation"},"content":{"rendered":"

\"Brain<\/a>Scientists have uncovered a molecular switch in the brain\u2019s immune system that may help explain why inflammation spirals out of control in Alzheimer\u2019s disease. By identifying how a key protein becomes overactive, the study points to a possible way to interrupt this damaging cycle and protect brain connections. Credit: Shutterstock<\/p>\n

A newly identified trigger of brain inflammation could offer a fresh target for slowing Alzheimer\u2019s progression.<\/p>\n

The brain has its own built-in immune system that identifies threats and responds to them. In Alzheimer\u2019s disease, growing evidence shows that this system becomes persistently overactive. The result is chronic inflammation that damages the connections between brain cells.<\/p>\n

In a preclinical study using human Alzheimer\u2019s brain cells, scientists at Scripps Research<\/a> have identified a molecular trigger behind this process. The finding points to a potential drug target that could help control harmful inflammation.<\/p>\n

A Molecular Switch Behind Inflammation<\/p>\n

The study, published in Cell Chemical Biology, focuses on a protein called STING. Under normal conditions, STING acts as part of the immune system\u2019s early warning network. In Alzheimer\u2019s brains, however, researchers found that STING undergoes a chemical change called S-nitrosylation (or SNO, a reaction involving sulfur, oxygen and nitrogen). This modification drives the protein into an overactive state. When scientists blocked this change in a mouse model, brain inflammation was reduced.<\/p>\n

\u201cThis is a new and important therapeutic target for Alzheimer\u2019s disease,\u201d says senior author Stuart Lipton, the Step Family Foundation Endowed Chair at Scripps Research and a clinical neurologist. \u201cIt\u2019s exciting to see that blocking this switch in mice reduces inflammation and protects the very brain cell connections that are lost in Alzheimer\u2019s, especially because we found the same pathway to be activated in human Alzheimer\u2019s brain samples and in human stem cell-derived models.\u201d<\/p>\n

\"Connections<\/a>Connections between nerve cells in the brain (synapses, labeled green) usually deteriorate in the brains of Alzheimer\u2019s mouse models (left). Stopping the formation of a molecule known as SNO-STING protects these connections between cells (right). Credit: Scripps Research<\/p>\n

More than 30 years ago, Lipton, who also co-directs the Neurodegeneration New Medicines Center at Scripps Research, first described S-nitrosylation. In this process, a molecule related to nitric oxide (NO) attaches to a cysteine amino acid in proteins, forming \u201cSNO\u201d and altering how the protein behaves.<\/p>\n

His lab later showed that SNO can be triggered by aging, inflammation, and environmental exposures such as air pollution and wildfire smoke. These changes can disrupt many proteins throughout the body. This widespread effect, referred to as a \u201cSNO-STORM,\u201d has been linked to diseases including cancer<\/a>, Parkinson\u2019s disease<\/a>, and Alzheimer\u2019s<\/a>.<\/p>\n

Pinpointing STING\u2019s Weak Spot<\/p>\n

In the new study, researchers took a closer look at STING, which had already been associated with Alzheimer\u2019s-related inflammation. Lipton\u2019s team, led by postdoctoral researcher Lauren Carnevale, worked with Professor John Yates III, a mass spectrometry expert at Scripps Research and holder of the John Lytton Young Endowed Chair.<\/p>\n

They identified the exact location where S-nitrosylation occurs on STING, focusing on a single amino acid known as cysteine 148. When this site is modified, STING forms clusters and sets off inflammatory signaling.<\/p>\n

Elevated levels of this altered form, called SNO-STING, were detected in postmortem brain tissue from Alzheimer\u2019s patients, in lab-grown human brain immune cells exposed to Alzheimer\u2019s proteins, and in mice with the disease.<\/p>\n

Further experiments revealed that hallmark Alzheimer\u2019s protein clumps, including amyloid-beta and alpha-synuclein, can directly trigger S-nitrosylation of STING. This suggests a feedback loop. Protein buildup, along with aging and environmental stress, may spark inflammation that produces nitric oxide. That, in turn, modifies STING and amplifies inflammation even further.<\/p>\n

Protecting Brain Connections<\/p>\n

To test this mechanism, the team created a version of STING that lacks cysteine 148, preventing the S-nitrosylation step. When introduced into a mouse model of Alzheimer\u2019s, this modified protein significantly reduced inflammation in brain immune cells.<\/p>\n

Importantly, it also preserved synapses, the connections between nerve cells that are essential for memory and thinking. Loss of synapses is closely linked to cognitive decline in dementia, so protecting them is a key goal in Alzheimer\u2019s research.<\/p>\n

\u201cWhat makes this target particularly promising is that we can quiet the pathological overactivation of STING without shutting down the normal immune response,\u201d says Lipton. \u201cYou still need STING to protect yourself from infections, and when we target cysteine 148, we\u2019re not blocking the entire molecule; we\u2019re just preventing STING from becoming overactivated.\u201d<\/p>\n

Lipton\u2019s team is now developing small molecules designed to block cysteine 148, with plans to test them in future preclinical studies.<\/p>\n

Reference: \u201cRedox regulation of neuroinflammatory pathways contributes to damage in Alzheimer\u2019s disease brain\u201d by Lauren N. Carnevale, Piu Banerjee, Xu Zhang, Jazmin Navarro, Charlene K Raspur, Parth Patel, Tomohiro Nakamura, Emily Schahrer, Henry Scott, Nhi Lang, Jolene K. Diedrich, Amanda J. Roberts, John R. Yates and Stuart A. Lipton, 23 April 2026, Cell Chemical Biology.
DOI: 10.1016\/j.chembiol.2026.03.017<\/a><\/p>\n

This work was supported in part by the National Institutes of Health (R35 AG071734, U01 AG088679, RF1 AG057409, R01 AG078756, R01 AG056259, R01 DA048882, DP1 DA041722 and R01 AG077046), and the U.S. Department of Defense\/U.S. Department of the Army (AR230101).<\/p>\n

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