{"id":726928,"date":"2026-06-26T09:18:18","date_gmt":"2026-06-26T09:18:18","guid":{"rendered":"https:\/\/www.newsbeep.com\/us\/726928\/"},"modified":"2026-06-26T09:18:18","modified_gmt":"2026-06-26T09:18:18","slug":"how-long-term-dietary-cholesterol-can-slow-down-its-own-clearance-by-liver-cells","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/us\/726928\/","title":{"rendered":"How long-term dietary cholesterol can slow down its own clearance by liver cells"},"content":{"rendered":"<p>                RESEARCH BRIEFINGS<br \/>\n                25 June 2026<\/p>\n<p>\n                    Cholesterol carried by low-density lipoprotein (LDL) drives heart disease and is cleared by liver cells expressing the receptor LDLR. A cell-signalling mechanism has been discovered through which high cholesterol promotes the enzyme-mediated degradation of LDLR. Blocking this enzyme restores LDLR levels in liver cells, suggesting a new strategy for treating high cholesterol.\n                <\/p>\n","protected":false},"excerpt":{"rendered":"RESEARCH BRIEFINGS 25 June 2026 Cholesterol carried by low-density lipoprotein (LDL) drives heart disease and is cleared by&hellip;\n","protected":false},"author":2,"featured_media":726929,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[32],"tags":[30589,1159,3625,1160,5963,79],"class_list":["post-726928","post","type-post","status-publish","format-standard","has-post-thumbnail","category-science","tag-cell-biology","tag-humanities-and-social-sciences","tag-metabolism","tag-multidisciplinary","tag-physiology","tag-science"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/726928","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/comments?post=726928"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/726928\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media\/726929"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media?parent=726928"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/categories?post=726928"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/tags?post=726928"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}