Insider Brief<\/p>\n
Researchers developed a single optical technique that simultaneously measures a material\u2019s chemical, structural, and mechanical properties from one point without touching or labeling the sample. <\/p>\n
The method combines three types of light-scattering signals using Specto Photonics\u2019 BIPD filter, allowing researchers to capture information that previously required multiple instruments and measurements. <\/p>\n
Tests on common pharmaceuticals showed the technique can distinguish between different forms of the same drug and could improve drug development, quality control, biomedical research, and materials science.<\/p>\n
Image: Photo by Placidplace<\/a> on Pixabay<\/a><\/p>\n PRESS RELEASE \u2014 An international team of researchers has developed an optical technique that measures the chemical, structural, and mechanical properties of a material at the same time, from a single point, and without touching or labeling the sample. The work, published in Nature Communications, is led by Milan-based deep-tech company Specto Photonics in collaboration with Politecnico di Milano and other academic partners across Italy, Denmark, and Australia.<\/p>\n One measurement instead of many<\/p>\n Until now, obtaining this combination of information meant using separate instruments and multiple measurements. The new method reads all of it from a single voxel of laser light, offering a faster and more complete way to analyze materials in pharmaceutical development, biomedical research, and materials science.<\/p>\n Three signals hidden in scattered light<\/p>\n The advance rests on capturing the full vibrational spectrum: the complete range of ways light scatters as it interacts with a material\u2019s molecular vibrations. Three complementary signals sit within that spectrum. Brillouin scattering reveals mechanical properties, ultra-low-frequency Raman reveals molecular structure and organization, and conventional Raman reveals chemical composition.<\/p>\n The faintest low-frequency signals, which carry the mechanical and structural information, are normally buried under intense scattered laser light, which is why they have been so difficult to capture alongside the rest. Specto Photonics proprietary Birefringence-Induced Phase Delay (BIPD) filter suppresses that background, allowing all three signals to be recorded together from the same spot.<\/p>\n \u201cThis approach reveals the significance of the combined information from different modalities which access the stiffness, molecular orientation and the chemical composition of the material by only shining laser light,\u201d said Dr Giuseppe Antonacci, coordinator of the project.<\/p>\n Proven on everyday medicines<\/p>\n The team tested the platform on widely used active pharmaceutical ingredients, including indomethacin, ibuprofen, and paracetamol. It distinguished between amorphous forms of the same drug produced by different manufacturing routes, a distinction conventional methods often cannot resolve, and mapped the mechanical, structural, and chemical makeup across an ibuprofen tablet.<\/p>\n Why it matters for drug development<\/p>\n A drug\u2019s solid-state form, whether crystalline or amorphous, and the way it is processed, directly affects its solubility, stability, shelf life, and how well the body absorbs it. Amorphous formulations are increasingly common yet notoriously difficult to characterize. A single, label-free measurement that captures mechanical, structural, and chemical detail at once could support formulation design, stability testing, and real-time quality control during manufacturing, with minimal sample waste.<\/p>\n Beyond pharmaceuticals<\/p>\n The applications extend well beyond drug development. Because the method is all-optical, non-contact, and works in three dimensions at diffraction-limited resolution, the researchers point to uses in biomedical research, for example in studying the mechanics and organization of structures inside living cells, and in materials science, where the mechanical, structural, and chemical state of a sample can be read together rather than one property at a time.<\/p>\n What comes next<\/p>\n The authors describe the work as a new framework for multimodal vibrational spectroscopy and imaging, and a step toward fully optical instruments that co-register three-dimensional mechanical, structural, and chemical maps of a sample at sub-micron resolution.<\/p>\n Publication<\/p>\n