{"id":781801,"date":"2026-07-24T12:40:24","date_gmt":"2026-07-24T12:40:24","guid":{"rendered":"https:\/\/www.newsbeep.com\/us\/781801\/"},"modified":"2026-07-24T12:40:24","modified_gmt":"2026-07-24T12:40:24","slug":"all-g-makes-us-debut-with-low-iron-lactoferrin","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/us\/781801\/","title":{"rendered":"All G makes US debut with low-iron lactoferrin"},"content":{"rendered":"

Australian startup All G<\/a> has made its US debut with LFX apo-lactoferrin<\/a>, bovine-equivalent lactoferrin made via precision fermentation with less than 5% iron saturation.<\/p>\n

An iron-binding anti-microbial protein found in mammalian milk, lactoferrin has multiple health\u00a0benefits<\/a>, but has historically only been available in small quantities owing to the high cost of isolating it from cow\u2019s milk.<\/p>\n

As a result, prices can top $650\/kilo, making it an attractive candidate for firms in precision fermentation, who claim they can unlock new markets in active nutrition, gut health, healthy aging, women\u2019s health, immune support, and infant formula.<\/p>\n

With multiple startups now piling into the segment (Vivici, All G, PFerrinX, TurtleTree, Helaina, Eclipse Ingredients, PFx Biotech, Daisy Labs, and Noumi), some players are attempting to differentiate themselves by modulating levels of iron saturation.<\/p>\n

In its \u201capo\u201d state, lactoferrin acts as a sponge for free iron and starves harmful bacteria and fungi that rely on iron to survive, claims All G.<\/p>\n

\u201cWhen iron saturation is low, empty iron-binding sites can bind excess free iron and help regulate homeostasis, limit iron available to harmful bacteria, support gut health, promote immune cell activity, and improve dietary iron absorption without requiring more iron to be consumed. The result is a fundamentally different approach to iron management. LFX works as an iron regulator, not just an iron source.\u201d<\/p>\n

An industry first<\/p>\n

CSO and cofounder Jared Raynes, PhD, told AgFunderNews: \u201cAlthough we welcome any competition, achieving a low iron saturation at commercial scale is significantly more challenging than at lab scale and we have yet to see any other company prove that it can be done.<\/p>\n

\u201cFrom publicly available data relating to our precision fermentation competitors, they are producing lactoferrin that is very highly saturated. On top of our low iron saturation, our product carries over 93% protein content, over 95% purity and over 95% binding to heparin \u2013 the latest industry standard measure for bioactivity.\u201d<\/p>\n

Asked how All G\u2019s apo-lactoferrin compared to animal-derived lactoferrin, he said: \u201cThe regular iron saturation of dairy-derived lactoferrin sits at around ~20%; whereas All G\u2019s specification sits at below 5%. The dairy industry can only achieve apo-lactoferrin through harsh intervention in downstream processing \u2013 by lowering the pH in order to strip the iron from the lactoferrin.\u201d<\/p>\n

According to Raynes, this process is \u201cwell known to degrade the protein. Up until now, apo-lactoferrin has only been offered for pharmaceutical applications as the price is close to double the price of partly saturated lactoferrin.\u201d<\/p>\n

\"AllAll G achieves the low iron saturation during the fermentation process rather than through the downstream processing, says CSO Jared Raynes. Image credit: All G
\nPositive unit economics<\/p>\n

All G, which has an FDA GRAS \u2018no questions\u2019 letter<\/a> for its bovine lactoferrin,\u00a0has proven its tech at pilot scale with D\u00f6hler<\/a> and is scaling up with contract manufacturers, said the firm, which is currently producing LFX at a scale of \u201cmultiple metric tons per year.\u201d<\/p>\n

CEO Jan Pacas added: \u201cWe are currently producing at 60,000-liter scale and at a yield that is giving us positive unit economics when selling at the current market price of milk-derived lactoferrin.<\/p>\n

\u201cWe are producing with one of the top global fermentation CMOs in China that gives us the scale and quality consistency that will allow us to scale precision fermented lactoferrin globally. Talks of a second facility, likely in Europe, are well underway. On this part we are leveraging our established relationships with our joint venture partner Savencia [a leading producer of bovine lactoferrin] and our strategic investor D\u00f6hler. All G keeps local stock in the US for fast fulfilment of US customers.\u201d<\/p>\n

The firm, which is backed by investors including Agronomics and D\u00f6hler Ventures, recently announced a joint venture with French dairy ingredients expert\u00a0Armor Prot\u00e9ines<\/a> and aims to capitalize on the latter\u2019s scientific expertise, distribution channels, and long-standing relationships with leading players in infant formula, adult nutrition, and supplements.<\/p>\n

Human lactoferrin will also come in apo-form<\/p>\n

All G hopes to secure self-affirmed GRAS status for human lactoferrin by the year end and aims to be on the market within six months, said Pacas.<\/p>\n

\u201cThe data we have generated from our scale-up human lactoferrin batches is significantly superior to what is currently on the market. One thing we can share now is that our human lactoferrin will also come in apo-form, mimicking human breast milk at around 4% iron saturation. \u201d<\/p>\n

He added: \u201cWe believe that human and bovine equivalent lactoferrin will co-exist, with human lactoferrin serving the markets where it makes the biggest difference such as women\u2019s health and infant nutrition. At the same time, bovine lactoferrin remains one of the most studied and proven proteins for human health, backed by thousands of peer reviewed papers and dozens of clinical trials. We can\u2019t simply dismiss that body of research and write off this protein just because human lactoferrin is now available.\u201d<\/p>\n

Bovine and human lactoferrin will be priced differently, \u201cputting bovine in a more accessible category and keeping the option open for formulators that are price conscious,\u201d he explained.<\/p>\n

According to Pacas, the \u201cmain market is for supplements, but increasingly we are seeing demand come in for functional foods and sports nutrition. We expect significant growth in the total market size for lactoferrin since lack of supply has been one of the main constraints for brands.\u201d<\/p>\n

Raynes added: \u201cThe traditional claim areas for lactoferrin are iron absorption, gut health and immune support. For all of these claim areas, the mechanisms are strengthened by the low-iron saturation in our apo-lactoferrin.\u201d<\/p>\n

Further reading:\u00a0<\/p>\n

Nestl\u00e9 taps Helaina to explore bioactive proteins in infant nutrition<\/a><\/p>\n

TurtleTree, Novonesis strike partnership to scale up precision-fermented lactoferrin<\/a><\/p>\n

PFerrinX tunes iron saturation for precision-fermented lactoferrin, aims to be \u2018largest and lowest cost producer\u2019<\/a><\/p>\n

Vivici bags $14.4m EIC funding to scale precision-fermented dairy proteins<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"Australian startup All G has made its US debut with LFX apo-lactoferrin, bovine-equivalent lactoferrin made via precision fermentation…\n","protected":false},"author":2,"featured_media":781802,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[61],"tags":[97,269,332830],"class_list":["post-781801","post","type-post","status-publish","format-standard","has-post-thumbnail","category-nutrition","tag-health","tag-nutrition","tag-precision-fermentation"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/781801","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/comments?post=781801"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/781801\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media\/781802"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media?parent=781801"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/categories?post=781801"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/tags?post=781801"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}