{"id":80374,"date":"2025-08-13T19:40:08","date_gmt":"2025-08-13T19:40:08","guid":{"rendered":"https:\/\/www.newsbeep.com\/us\/80374\/"},"modified":"2025-08-13T19:40:08","modified_gmt":"2025-08-13T19:40:08","slug":"how-to-manage-autoimmune-disease-risk-with-primary-immunodeficiency","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/us\/80374\/","title":{"rendered":"How to Manage Autoimmune Disease Risk With Primary Immunodeficiency"},"content":{"rendered":"<p>To understand how PI can raise your risk of <a class=\"cr-anchor\" href=\"https:\/\/www.everydayhealth.com\/autoimmune-diseases\/\" rel=\"nofollow noopener\" target=\"_blank\">autoimmune diseases<\/a>, it\u2019s helpful to know a bit more about how the immune system works. In immunology, there is a concept called self-tolerance, which is the immune system\u2019s ability to differentiate between its own cells and foreign bodies, such as bacteria.<\/p>\n<p class=\"view-sources\">[2]<\/p>\n<p>\u00a0If self-tolerance fails, says Dr. Ballow, the body may attack its own healthy cells, which is known as autoimmunity. The immune system abnormalities in PI can cause these disruptions, potentially causing autoimmune disease.<\/p>\n<p class=\"view-sources\">[3]<\/p>\n<p>Autoimmune problems can affect both children and adults with PI. They\u2019re especially common in certain types of PI, including common variable immune deficiency, complement deficiencies, Good syndrome, hyper immunoglobulin M syndrome, idiopathic T cell lymphocytopenia, selective immunoglobulin A deficiency, and Wiskott-Aldrich syndrome.<\/p>\n<p>While there\u2019s no proven way to prevent autoimmune diseases in people with PI, staying proactive about your healthcare may make a difference. \u201cWe can\u2019t really predict which patients will develop autoimmune disease,\u201d says Ballow. \u201cHowever, if we do genetic testing and we define a genetic abnormality &#8230; we can follow you a little more closely and perhaps catch an autoimmune process a little earlier.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"To understand how PI can raise your risk of autoimmune diseases, it\u2019s helpful to know a bit more&hellip;\n","protected":false},"author":2,"featured_media":80375,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[50],"tags":[200,79],"class_list":["post-80374","post","type-post","status-publish","format-standard","has-post-thumbnail","category-genetics","tag-genetics","tag-science"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/80374","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/comments?post=80374"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/80374\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media\/80375"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media?parent=80374"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/categories?post=80374"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/tags?post=80374"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}