{"id":84854,"date":"2025-08-15T13:41:09","date_gmt":"2025-08-15T13:41:09","guid":{"rendered":"https:\/\/www.newsbeep.com\/us\/84854\/"},"modified":"2025-08-15T13:41:09","modified_gmt":"2025-08-15T13:41:09","slug":"from-gene-hunter-to-drug-hunter","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/us\/84854\/","title":{"rendered":"From gene hunter to drug hunter"},"content":{"rendered":"<p> Howard Chang wasn\u2019t looking for a change from his job at Stanford, where he worked as both a genomic researcher and a dermatologist. His busy lab there was focused on understanding how regulatory programmes drive disease \u2014 unveiling for example how long-non-coding RNA (lncRNA) underpins autoimmunity in women and how extrachromosomal DNA (ecDNA) fuels cancer. And with five biotech startups already under his belt, Chang saw a path to transform these big ideas into drugs. But when he got a call from Amgen\u2019s head of R&amp;D Jay Bradner about joining the big biotech team, he couldn\u2019t resist the change.<\/p>\n<p>                Enjoying our latest content? <br \/>Login or create an account to continue<\/p>\n<p>                Access the most recent journalism from Nature&#8217;s award-winning team<br \/>\n                Explore the latest features &amp; opinion covering groundbreaking research<\/p>\n<p class=\"app-access-wall__option-separator\">or<\/p>\n<p>Interviewed by Asher Mullard<\/p>\n<p>The interview was edited for length and clarity.<\/p>\n","protected":false},"excerpt":{"rendered":"Howard Chang wasn\u2019t looking for a change from his job at Stanford, where he worked as both a&hellip;\n","protected":false},"author":2,"featured_media":84855,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[32],"tags":[258,244,8869,257,58810,8872,13256,79],"class_list":["post-84854","post","type-post","status-publish","format-standard","has-post-thumbnail","category-science","tag-biomedicine","tag-biotechnology","tag-cancer-research","tag-general","tag-medicinal-chemistry","tag-molecular-medicine","tag-pharmacology-toxicology","tag-science"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/84854","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/comments?post=84854"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/84854\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media\/84855"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media?parent=84854"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/categories?post=84854"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/tags?post=84854"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}