{"id":857923,"date":"2026-09-23T15:50:11","date_gmt":"2026-09-23T15:50:11","guid":{"rendered":"https:\/\/www.newsbeep.com\/us\/857923\/"},"modified":"2026-09-23T15:50:11","modified_gmt":"2026-09-23T15:50:11","slug":"college-football-odds-picks-predictions-week-4-best-bets","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/us\/857923\/","title":{"rendered":"College football odds, picks, predictions, Week 4 best bets"},"content":{"rendered":"

The Week 4 college football schedule is when conference play officially kicks off for many teams. The Big Ten features the likes of USC vs. Oregon (-3.5) and Michigan vs. Iowa (+5.5) to make Week 4 college football picks on, with the SEC offering Texas vs. Tennessee (+4.5), with Colorado vs. Baylor (-10) over in the Big 12. Elsewhere, Notre Dame vs. Purdue is always a hotly contested in-state rivalry as the two Battle for the Shillelagh Trophy in their 90th all-time meeting, with the Irish, who are favored by 27.5 points, having won each of the last eight matchups.\u00a0Claim the latest Polymarket promo code CBSSPORTS to get a $50 bonus after $10 in trades<\/a>:<\/p>\n

Speaking of in-state matchups, Carolinians will look forward to NC State vs. App State (+14), with the Wolfpack looking to rebound after a shocking last-second defeat to Vanderbilt. Before locking in any Week 4 college football picks, be sure to see the latest college football predictions from SportsLine’s proven model<\/a>.<\/p>\n

The model simulates every FBS game 10,000 times. It is off to a profitable 22-19 start on all top-rated college football picks at\u00a0betting sites<\/a>\u00a0so far this season, and it has been upgraded for the 2026 season to better factor in the transfer portal. Anybody following its picks on college football betting sites<\/a> could have seen strong returns.<\/p>\n

Now, it has turned its attention to the latest college football odds<\/a> for Week 4 and locked in picks for every FBS matchup.\u00a0Head here to see every pick<\/a>.<\/p>\n

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Top college football predictions for Week 4<\/p>\n

One of the top Week 4 college football picks the model is recommending for best betting apps<\/a>: Colorado (+10, 55.5) covers at Baylor in a noon ET kickoff. The Buffs were blown out by Northwestern last week, but Colorado has shown resiliency under Deion Sanders, going 11-5-2 ATS after a loss. That 69% cover rate is 10th-best in FBS since Sanders’ first season in 2023 (min. 5 games). Meanwhile, no team in college football handles success worse than Baylor in terms of the spread. The Bears defeated Louisiana Tech last Saturday, but Baylor is 0-6 ATS after a win, dating back to 2025. The Buffs cover in well over 50% of simulations in an A-rated pick, while the Over hits 56% of the time.<\/p>\n

Another Week 4 prediction: USC (+3, 61.5) covers at home versus Oregon at 7:30 p.m. ET in almost 60% of simulations. QB Jayden Maiava sports an 11-1 home record with USC, and the offense looks unstoppable. USC has scored 35-plus in each of the first four games of a season for just the third time in the storied history of the program. Oregon has struggled in its two games versus FBS teams, defeating Boise State by a touchdown, despite being favored by 25.5 points, and losing to Oklahoma State as 24-point favorites. Maiava is projected to have more yards, more touchdowns and fewer interceptions than his counterpart in Oregon QB Dante Moore. The model has USC covering in a highly-rated pick and says the Under hits more than 60% of the time.\u00a0See which other picks the model likes here<\/a>.<\/p>\n

How to make college football picks for Week 4<\/p>\n

The model has also made the call on who wins and covers in every Week 4 college football game, including a top 5 team which outright loses in one of the week’s biggest games.\u00a0You can only get every pick for every game at SportsLine<\/a>.<\/p>\n

So what college football picks can you make with confidence, and which top-5 ranked team goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that is on a profitable 22-19 run<\/a>, and find out.<\/p>\n

College football odds for Week 4 notable games<\/p>\n

See full Week 4 college football picks, odds, predictions here<\/a>
(odds subject to change)<\/p>\n

Thursday, Sep. 24
Liberty at Coastal Carolina (+2.5, 50.5)<\/p>\n

Friday, Sep. 25
Army at Temple (+3. 48.5)
Navy at UAB (+7, 51.5)
Northwestern at Indiana (-21, 49.5)
Clemson at California (+1.5, 50.5)<\/p>\n

Saturday, Sep. 26
Texas at Tennessee (+4.5, 55.5)
Illinois at Ohio State (-27.5, 53.5)
Oklahoma at Georgia (-14, 44.5)
Ole Miss at Florida (-3.5, 58.5)
Iowa at Michigan (-5.5, 38.5)
Wisconsin at Penn State (-10, 44.5)
South Carolina at Alabama (-12.5, 53.5)
Texas A&M at LSU (-8.5, 51.5)
Oregon at USC (+3, 61.5)
Missouri at Mississippi State (-6.5, 58.5)<\/p>\n","protected":false},"excerpt":{"rendered":"The Week 4 college football schedule is when conference play officially kicks off for many teams. The Big…\n","protected":false},"author":2,"featured_media":857924,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[67],"tags":[1775,2205,56302,69392,95704,113882,93783,362232,362231,1602,399,398,396,397,5693,99,14034],"class_list":["post-857923","post","type-post","status-publish","format-standard","has-post-thumbnail","category-ncaa-football","tag-baylor-bears","tag-betting","tag-college-football-best-bets","tag-college-football-betting","tag-college-football-odds","tag-college-football-picks","tag-college-football-predictions","tag-college-football-week-4-odds","tag-college-football-week-4-picks","tag-colorado-buffaloes","tag-football","tag-ncaa","tag-ncaa-football","tag-ncaafootball","tag-oregon-ducks","tag-sports","tag-usc-trojans"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/857923","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/comments?post=857923"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/857923\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media\/857924"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media?parent=857923"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/categories?post=857923"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/tags?post=857923"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}