{"id":858979,"date":"2026-09-24T13:24:11","date_gmt":"2026-09-24T13:24:11","guid":{"rendered":"https:\/\/www.newsbeep.com\/us\/858979\/"},"modified":"2026-09-24T13:24:11","modified_gmt":"2026-09-24T13:24:11","slug":"lsp2-links-mtorc1-to-top-mrna-translation-and-lifespan-in-drosophila","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/us\/858979\/","title":{"rendered":"Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila"},"content":{"rendered":"

Liu, G. Y. & Sabatini, D. M. mTOR at the nexus of nutrition, growth, ageing and disease. Nat. Rev. Mol. Cell Biol. 21, 183\u2013203 https:\/\/doi.org\/10.1038\/s41580-019-0199-y<\/a> (2020).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Meyuhas, O. & Kahan, T. The race to decipher the top secrets of TOP mRNAs. Biochim. Biophys. Acta 1849, 801\u2013811 https:\/\/doi.org\/10.1016\/j.bbagrm.2014.08.015<\/a> (2015).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Thoreen, C. C. et al. A unifying model for mTORC1-mediated regulation of mRNA translation. Nature 485, 109\u2013113 https:\/\/doi.org\/10.1038\/nature11083<\/a> (2012).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Valzania, L., Alami, A. & Leopold, P. A temporal allocation of amino acid resources ensures fitness and body allometry in Drosophila. Dev. Cell 59, 2277\u20132286 https:\/\/doi.org\/10.1016\/j.devcel.2024.05.018<\/a> (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Fontana, L. & Partridge, L. Promoting health and longevity through diet: from model organisms to humans. Cell 161, 106\u2013118 https:\/\/doi.org\/10.1016\/j.cell.2015.02.020<\/a> (2015).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Obata, F. & Miura, M. Regulatory mechanisms of aging through the nutritional and metabolic control of amino acid signaling in model organisms. Annu. Rev. Genet. 58, 19\u201341 https:\/\/doi.org\/10.1146\/annurev-genet-111523-102042<\/a> (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Valvezan, A. J. & Manning, B. D. Molecular logic of mTORC1 signalling as a metabolic rheostat. Nat. Metab. 1, 321\u2013333 https:\/\/doi.org\/10.1038\/s42255-019-0038-7<\/a> (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

MacInnes, A. W. The role of the ribosome in the regulation of longevity and lifespan extension. Wiley Interdiscip. Rev. RNA 7, 198\u2013212 https:\/\/doi.org\/10.1002\/wrna.1325<\/a> (2016).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Bjedov, I. et al. Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab. 11, 35\u201346 https:\/\/doi.org\/10.1016\/j.cmet.2009.11.010<\/a> (2010).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Johnson, S. C., Rabinovitch, P. S. & Kaeberlein, M. mTOR is a key modulator of ageing and age-related disease. Nature 493, 338\u2013345 https:\/\/doi.org\/10.1038\/nature11861<\/a> (2013).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Mannick, J. B. & Lamming, D. W. Targeting the biology of aging with mTOR inhibitors. Nat. Aging 3, 642\u2013660 https:\/\/doi.org\/10.1038\/s43587-023-00416-y<\/a> (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Hsieh, A. C. et al. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature 485, 55\u201361 https:\/\/doi.org\/10.1038\/nature10912<\/a> (2012).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Peter, D. et al. Molecular architecture of 4E-BP translational inhibitors bound to eIF4E. Mol. Cell 57, 1074\u20131087 https:\/\/doi.org\/10.1016\/j.molcel.2015.01.017<\/a> (2015).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Gingras, A. C. et al. Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev. 15, 2852\u20132864 https:\/\/doi.org\/10.1101\/gad.912401<\/a> (2001).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Morita, M. et al. mTOR controls mitochondrial dynamics and cell survival via MTFP1. Mol. Cell 67, 922\u2013935 https:\/\/doi.org\/10.1016\/j.molcel.2017.08.013<\/a> (2017).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Tatar, M., Post, S. & Yu, K. Nutrient control of Drosophila longevity. Trends Endocrinol. Metab. 25, 509\u2013517 https:\/\/doi.org\/10.1016\/j.tem.2014.02.006<\/a> (2014).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Teleman, A. A., Chen, Y. W. & Cohen, S. M. 4E-BP functions as a metabolic brake used under stress conditions but not during normal growth. Genes Dev. 19, 1844\u20131848 https:\/\/doi.org\/10.1101\/gad.341505<\/a> (2005).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Tettweiler, G., Miron, M., Jenkins, M., Sonenberg, N. & Lasko, P. F. Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP. Genes Dev. 19, 1840\u20131843 https:\/\/doi.org\/10.1101\/gad.1311805<\/a> (2005).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zid, B. M. et al. 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Cell 139, 149\u2013160 https:\/\/doi.org\/10.1016\/j.cell.2009.07.034<\/a> (2009).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Bai, H., Post, S., Kang, P. & Tatar, M. Drosophila longevity assurance conferred by reduced insulin receptor substrate chicopartially requires d4eBP. PLoS ONE 10, e0134415 https:\/\/doi.org\/10.1371\/journal.pone.0134415<\/a> (2015).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Grandison, R. C., Piper, M. D. & Partridge, L. Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila. Nature 462, 1061\u20131064 https:\/\/doi.org\/10.1038\/nature08619<\/a> (2009).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Bene\u0161, H. et al. Adult expression of the Drosophila Lsp-2 gene. Dev. Biol. 142, 138\u2013146 https:\/\/doi.org\/10.1016\/0012-1606(90)90157-e<\/a> (1990).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Sang, J. H. & King, R. C. Nutritional requirements of axenically cultured Drosophila melanogaster adults. J. Exp. Biol. 38, 793\u2013809 https:\/\/doi.org\/10.1242\/jeb.38.4.793<\/a> (1961).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Tiebe, M. et al. REPTOR and REPTOR-BP regulate organismal metabolism and transcription downstream of TORC1. Dev. Cell 33, 272\u2013284 https:\/\/doi.org\/10.1016\/j.devcel.2015.03.013<\/a> (2015).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Liu, G. Y., Jouandin, P., Bahng, R. E., Perrimon, N. & Sabatini, D. M. An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway. Nat. Commun. 15, 2517 https:\/\/doi.org\/10.1038\/s41467-024-46680-3<\/a> (2024).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Gu, X. et al. Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila. Nature 608, 209\u2013216 https:\/\/doi.org\/10.1038\/s41586-022-04960-2<\/a> (2022).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Lu, J. et al. Sestrin is a key regulator of stem cell function and lifespan in response to dietary amino acids. Nat. Aging 1, 60\u201372 https:\/\/doi.org\/10.1038\/s43587-020-00001-7<\/a> (2021).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Hwangbo, D. S., Gershman, B., Tu, M. P., Palmer, M. & Tatar, M. Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 429, 562\u2013566 https:\/\/doi.org\/10.1038\/nature02549<\/a> (2004).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Figlia, G. et al. mTORC1 senses glutamine and other amino acids through GCN2. EMBO J. 44, 4825\u20134866 https:\/\/doi.org\/10.1038\/s44318-025-00505-1<\/a> (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ye, J. et al. GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2. Genes Dev. 29, 2331\u20132336 https:\/\/doi.org\/10.1101\/gad.269324.115<\/a> (2015).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Carvalho-Santos, Z. & Ribeiro, C. Gonadal ecdysone titers are modulated by protein availability but do not impact protein appetite. J. Insect Physiol. 106, 30\u201335 https:\/\/doi.org\/10.1016\/j.jinsphys.2017.08.006<\/a> (2018).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Benes, H. et al. Overlapping Lsp-2 gene sequences target expression to both the larval and adult Drosophila fat body. Insect Mol. Biol. 5, 39\u201349 https:\/\/doi.org\/10.1111\/j.1365-2583.1996.tb00039.x<\/a> (1996).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kapahi, P. et al. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr. Biol. 14, 885\u2013890 https:\/\/doi.org\/10.1016\/j.cub.2004.03.059<\/a> (2004).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Bass, T. M. et al. Optimization of dietary restriction protocols in Drosophila. J. Gerontol. A 62, 1071\u20131081 https:\/\/doi.org\/10.1093\/gerona\/62.10.1071<\/a> (2007).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Clancy, D. J. et al. Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292, 104\u2013106 https:\/\/doi.org\/10.1126\/science.1057991<\/a> (2001).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Tatar, M. et al. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292, 107\u2013110 https:\/\/doi.org\/10.1126\/science.1057987<\/a> (2001).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

O\u2019Brien, D. M., Min, K.-J., Larsen, T. & Tatar, M. Use of stable isotopes to examine how dietary restriction extends Drosophila lifespan. Curr. Biol. 18, R155\u2013R156 https:\/\/doi.org\/10.1016\/j.cub.2008.01.021<\/a> (2008).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Yamamoto, R., Palmer, M., Koski, H., Curtis-Joseph, N. & Tatar, M. Aging modulated by the Drosophila insulin receptor through distinct structure-defined mechanisms. Genetics 217, iyaa037 https:\/\/doi.org\/10.1093\/genetics\/iyaa037<\/a> (2021).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zanco, B., Mirth, C. K., Sgr\u00f2, C. M. & Piper, M. D. A dietary sterol trade-off determines lifespan responses to dietary restriction in Drosophila melanogaster females. eLife 10, e62335 https:\/\/doi.org\/10.7554\/eLife.62335<\/a> (2021).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Yamamoto, R., Bai, H., Dolezal, A. G., Amdam, G. & Tatar, M. Juvenile hormone regulation of Drosophila aging. BMC Biol. 11, 85 https:\/\/doi.org\/10.1186\/1741-7007-11-85<\/a> (2013).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wek, R. C. Role of eIF2\u03b1 kinases in translational control and adaptation to cellular stress. Cold Spring Harb. Perspect. Biol. 10, a032870 https:\/\/doi.org\/10.1101\/cshperspect.a032870<\/a> (2018).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kim, H. S. et al. Early-adulthood spike in protein translation drives aging via juvenile hormone\/germline signaling. Nat. Commun. 14, 5021 https:\/\/doi.org\/10.1038\/s41467-023-40618-x<\/a> (2023).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Recasens-Alvarez, C. et al. Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition. Nat. Cell Biol. 23, 127\u2013135 https:\/\/doi.org\/10.1038\/s41556-020-00626-1<\/a> (2021).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Sung, M. K. et al. A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins. eLife 5, e19105 https:\/\/doi.org\/10.7554\/eLife.19105<\/a> (2016).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Romero-Pozuelo, J., Demetriades, C., Schroeder, P. & Teleman, A. A. CycD\/Cdk4 and discontinuities in Dpp signaling activate TORC1 in the Drosophila wing disc. Dev. Cell 42, 376\u2013387 https:\/\/doi.org\/10.1016\/j.devcel.2017.07.019<\/a> (2017).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kosakamoto, H. et al. Lsp2 links early-life diet to adult translation and lifespan in Drosophila. Nature https:\/\/doi.org\/10.1038\/s41586-026-11031-3<\/a> (2026).<\/p>\n

Philippe, L., van den Elzen, A. M. G., Watson, M. J. & Thoreen, C. C. Global analysis of LARP1 translation targets reveals tunable and dynamic features of 5\u2032 TOP motifs. Proc. Natl Acad. Sci. USA 117, 5319\u20135328 https:\/\/doi.org\/10.1073\/pnas.1912864117<\/a> (2020).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Meyuhas, O. Synthesis of the translational apparatus is regulated at the translational level. Eur. J. Biochem. 267, 6321\u20136330 https:\/\/doi.org\/10.1046\/j.1432-1327.2000.01719.x<\/a> (2000).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Marygold, S. J. et al. The ribosomal protein genes and Minute loci of Drosophila melanogaster. Genome Biol. 8, R216 https:\/\/doi.org\/10.1186\/gb-2007-8-10-r216<\/a> (2007).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Leader, D. P., Krause, S. A., Pandit, A., Davies, S. A. & Dow, J. A. T. FlyAtlas 2: a new version of the Drosophila melanogaster expression atlas with RNA-seq, miRNA-seq and sex-specific data. Nucleic Acids Res. 46, D809\u2013D815 https:\/\/doi.org\/10.1093\/nar\/gkx976<\/a> (2018).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Hern\u00e1ndez, G., Altmann, M. & Lasko, P. Origins and evolution of the mechanisms regulating translation initiation in eukaryotes. Trends Biochem. Sci. 35, 63\u201373 https:\/\/doi.org\/10.1016\/j.tibs.2009.10.009<\/a> (2010).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Sun, J. et al. Drosophila FIT is a protein-specific satiety hormone essential for feeding control. Nat. Commun. 8, 14161 https:\/\/doi.org\/10.1038\/ncomms14161<\/a> (2017).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Vidarsson, G., Dekkers, G. & Rispens, T. IgG subclasses and allotypes: from structure to effector functions. Front. Immunol. 5, 520 https:\/\/doi.org\/10.3389\/fimmu.2014.00520<\/a> (2014).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Jones, D. D. et al. mTOR has distinct functions in generating versus sustaining humoral immunity. J. Clin. Invest. 126, 4250\u20134261 https:\/\/doi.org\/10.1172\/JCI86504<\/a> (2016).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Yu, L. et al. IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline. Cell Metab. 36, 793\u2013807 https:\/\/doi.org\/10.1016\/j.cmet.2024.01.015<\/a> (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ma, S. et al. Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging. Cell 187, 7025\u20137044 https:\/\/doi.org\/10.1016\/j.cell.2024.10.019<\/a> (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Jin, H. et al. TRIBE editing reveals specific mRNA targets of eIF4E-BP in Drosophila and in mammals. Sci. Adv. 6, eabb8771 https:\/\/doi.org\/10.1126\/sciadv.abb8771<\/a> (2020).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Berman, A. J. et al. Controversies around the function of LARP1. RNA Biol. 18, 207\u2013217 https:\/\/doi.org\/10.1080\/15476286.2020.1733787<\/a> (2021).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Blagden, S. P. et al. Drosophila Larp associates with poly(A)-binding protein and is required for male fertility and syncytial embryo development. Dev. Biol. 334, 186\u2013197 https:\/\/doi.org\/10.1016\/j.ydbio.2009.07.016<\/a> (2009).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Narla, A. & Ebert, B. L. Ribosomopathies: human disorders of ribosome dysfunction. Blood 115, 3196\u20133205 https:\/\/doi.org\/10.1182\/blood-2009-10-178129<\/a> (2010).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

McGuire, S. E., Mao, Z. & Davis, R. L. Spatiotemporal gene expression targeting with the TARGET and gene-switch systems in Drosophila. Sci. STKE 2004, pl6 https:\/\/doi.org\/10.1126\/stke.2202004pl6<\/a> (2004).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Osterwalder, T., Yoon, K. S., White, B. H. & Keshishian, H. A conditional tissue-specific transgene expression system using inducible GAL4. Proc. Natl Acad. Sci. USA 98, 12596\u201312601 https:\/\/doi.org\/10.1073\/pnas.221303298<\/a> (2001).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Roman, G., Endo, K., Zong, L. & Davis, R. L. P{Switch}, a system for spatial and temporal control of gene expression in Drosophila melanogaster. Proc. Natl Acad. Sci. USA 98, 12602\u201312607 https:\/\/doi.org\/10.1073\/pnas.221303998<\/a> (2001).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zhang, S. et al. Eclosion muscles secrete ecdysteroids to initiate asymmetric intestinal stem cell division in Drosophila. Dev. Cell 59, 125\u2013140 https:\/\/doi.org\/10.1016\/j.devcel.2023.11.016<\/a> (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Port, F. et al. A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila. eLife 9, e53865 https:\/\/doi.org\/10.7554\/eLife.53865<\/a> (2020).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Piper, M. D. et al. A holidic medium for Drosophila melanogaster. Nat. Methods 11, 100\u2013105 https:\/\/doi.org\/10.1038\/nmeth.2731<\/a> (2014).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kosakamoto, H. et al. Sensing of the non-essential amino acid tyrosine governs the response to protein restriction in Drosophila. Nat. Metab. 4, 944\u2013959 https:\/\/doi.org\/10.1038\/s42255-022-00608-7<\/a> (2022).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zhai, Z., Boquete, J. P. & Lemaitre, B. Cell-specific Imd-NF-\u03baB responses enable simultaneous antibacterial immunity and intestinal epithelial cell shedding upon bacterial infection. Immunity 48, 897\u2013910 https:\/\/doi.org\/10.1016\/j.immuni.2018.04.010<\/a> (2018).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Luo, S. et al. Drosophila ts RNAs preferentially suppress general translation machinery via antisense pairing and participate in cellular starvation response. Nucleic Acids Res. 46, 5250\u20135268 https:\/\/doi.org\/10.1093\/nar\/gky189<\/a> (2018).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Chen, T. et al. The Drosophila NPY-like system protects against chronic stress-induced learning deficit by preventing the disruption of autophagic flux. Proc. Natl Acad. Sci. USA 120, e2307632120 https:\/\/doi.org\/10.1073\/pnas.2307632120<\/a> (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Chothani, S. et al. deltaTE: detection of translationally regulated genes by integrative analysis of Ribo-seq and RNA-seq data. Curr Protoc Mol Biol 129, e108 https:\/\/doi.org\/10.1002\/cpmb.108<\/a> (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Chen, J. et al. Piwi regulates the usage of alternative transcription start sites in the Drosophila ovary. Nucleic Acids Res. 53, gkae1160 https:\/\/doi.org\/10.1093\/nar\/gkae1160<\/a> (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Hoskins, R. A. et al. Genome-wide analysis of promoter architecture in Drosophila melanogaster. Genome Res. 21, 182\u2013192 https:\/\/doi.org\/10.1101\/gr.112466.110<\/a> (2011).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Cai, Z. Code release for \u201cLsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila\u201d. Zenodo https:\/\/doi.org\/10.5281\/zenodo.21473950<\/a> (2026).<\/p>\n","protected":false},"excerpt":{"rendered":"Liu, G. Y. & Sabatini, D. M. mTOR at the nexus of nutrition, growth, ageing and disease. Nat.…\n","protected":false},"author":2,"featured_media":858980,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[32],"tags":[5962,201541,1159,1160,51077,79,92244,362624],"class_list":["post-858979","post","type-post","status-publish","format-standard","has-post-thumbnail","category-science","tag-ageing","tag-animal-physiology","tag-humanities-and-social-sciences","tag-multidisciplinary","tag-ribosome","tag-science","tag-senescence","tag-tor-signalling"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/858979","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/comments?post=858979"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/858979\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media\/858980"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media?parent=858979"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/categories?post=858979"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/tags?post=858979"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}