published Wednesday in the journal Nature<\/a>, took advantage of a natural experiment: It looked at what happened to gut bacteria in cancer patients who were hospitalized and treated with sustained antibiotics before receiving stem cell transplants. Because the patients only ate food prepared by the hospital, researchers knew exactly what and how much food they ate \u2013 a rarity in nutrition studies, which typically rely on participants to recall what they ate hours or days earlier, something people are notoriously bad at.\n <\/p>\n\n The gut microbiome consists of trillions of bacteria, viruses and other microbes that populate human intestines. These tiny organisms perform a host of functions including helping with digestion, making essential vitamins, and playing a role in immune function. Science has shown the microbiome also communicates with the brain to produce neurotransmitters like serotonin, which are important for sleep, mood and stress levels.\n <\/p>\n
\n Studies have shown that the numbers and variety of bacteria that live in the gut depend largely on diet. People who eat varied, plant-based, fiber-rich diets tend to have higher diversity of organisms in the intestines compared with those who eat diets with more highly processed foods. In general, the more diverse a person\u2019s microbiome is, the healthier it is. A dense, diverse community of bugs in the gut is able to prevent bad actors \u2013 called pathobionts \u2013 from taking over and causing illness.\n <\/p>\n
\n \u201cOne of the things that that differentiates this study from other ones that have been previously published is that the patients are having their microbiome pummeled, and they\u2019re also having their nutritional state disrupted by the cancer treatment,\u201d said study author Dr. Jonathan Peled, a physician scientist at Memorial Sloan Kettering.\n <\/p>\n
\n The research, which was led by scientists at Memorial Sloan Kettering Cancer Center and NYU\u2019s Langone Health in New York, and City of Hope Cancer Center in Los Angeles, looked at what happened after antibiotics and hospital food destabilized and disrupted normal gut flora. They used this state of disruption as a window to see the effects of certain types of foods on the composition of the gut microbiome.\n <\/p>\n
\n \u201cWe sliced and diced the data in different ways,\u201d Peled said.\n <\/p>\n
\n They looked at the relationship between broad categories of macronutrients like fat, carbohydrates and fiber, and different types of gut bacteria. They also looked at the effects of specific foods like chicken, apples and chocolate cake.\n <\/p>\n
\n \u201cAnd the theme that kept popping up over and over again was the more sugary foods you eat, no matter what type of sugar it is \u2013 with particularly noxious effects from added sugars \u2013 it seemed that really seemed to synergize with antibiotics in terms of damaging the microbiome,\u201d Peled said.\n <\/p>\n
\n The study drew its data from more than 1,000 stool samples, collected from 173 patients, who ate more than 9,400 hospital prepared meals.\n <\/p>\n
\n Across the board, the more intense a patient\u2019s antibiotic regimen was, the greater the loss of diversity in their microbiome.\n <\/p>\n
\n They found most types of foods were not associated with changes to the diversity of bacteria found the in the gut. Sweets, however \u2013 which the researchers defined as sugars, and sweetened foods and beverages \u2013 were a different story. For every 3.5-ounce increase in consumption of sweets while on antibiotic treatment, the diversity of a patient\u2019s microbiome measured in their stool sample decreased by about 24%, the study showed.\n <\/p>\n
\n The decrease in gut bacteria diversity was tied to expansions in populations of certain bad actors, such as the bacteria Enterococcus faecium.\n <\/p>\n
\n Enterococcus is an opportunistic organism. It hangs around harmlessly in the gut and is kept in check by other types of bacteria that outcompete it. But when there\u2019s a disruption, such as antibiotic treatment that wipes out the other bacteria, it can start to overgrow. In some cases, it may slip through the gut wall and into the bloodstream, where it can cause sepsis.\n <\/p>\n
\n \u201cIn bone marrow transplant specifically, we found that Enterococcus can make certain complications of transplant worse, something called graft versus host disease,\u201d Peled said.\n <\/p>\n
\n In graft versus host disease, donated stem cells recognize a recipient\u2019s body as foreign and begin to attack their healthy tissues.\n <\/p>\n
\n The team also tested to see if they could recreate the microbiome shifts they saw in human cancer patients in mice. They gave mice a single injection of a broad spectrum antibiotic and saw a small increase in Enterococcus bacteria. When they also fed the mice added sugar after the antibiotic shot, the amount of Enterococci bacteria increased 16-fold by day three and 33-fold by day six.\n <\/p>\n
\n This increase may have real consequences, too.\n <\/p>\n
\n Overall, patients who ate more sugar than average had about a 12% higher risk of dying after their transplants compared with those who didn\u2019t consume as much. It\u2019s a small but significant increase in risk.\n <\/p>\n
\n \u201cIt\u2019s a modest change in their risk profile,\u201d Peled said.\n <\/p>\n
\n The expansion of Enterococcus bacteria lasted about eight days after antibiotic treatment.\n <\/p>\n
\n \u201cIt\u2019s a pretty neat study,\u201d said Dr. Anthony Maresso, professor of virology and microbiology at the Baylor College of Medicine in Houston. \u201cI suspect it\u2019s going to make some waves,\u201d added Maresso, who was not involved in the research.\n <\/p>\n
\n \u201cThis has significance for these transplant recipients because that\u2019s the number one thing hospitals are worried about is that they\u2019re going to get infections in the clinical care setting,\u201d Maresso said. \u201cMakes me wonder about whether we should change the diet of hospitals.\u201d\n <\/p>\n
\n The next question, he said, is whether this study has significance for people who take antibiotics outside a hospital setting. Does a high-sugar diet on antibiotics for, say, an ear infection, set you up for other infections down the road, for example?\n <\/p>\n
\n Peled said while thee study is provocative, it\u2019s not a randomized, controlled clinical trial where researchers are able to test different diets to see which one might be most protective for people taking antibiotics.\n <\/p>\n
\n Because it\u2019s generally a good idea to avoid eating too much sugar, he said, it\u2019s not unreasonable to considering limiting sugar during antibiotic treatment.\n <\/p>\n
\n \u201cWhat our study suggests might work is not to avoid sugar or sugary foods during your entire time, but specifically when you\u2019re on antibiotics,\u201d Peled said.\n <\/p>\n","protected":false},"excerpt":{"rendered":"Sugary foods combined with antibiotic treatment can damage the gut microbiome in ways that could leave people vulnerable…\n","protected":false},"author":2,"featured_media":867318,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[97],"class_list":["post-867317","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/867317","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/comments?post=867317"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/867317\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media\/867318"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media?parent=867317"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/categories?post=867317"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/tags?post=867317"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}