{"id":880494,"date":"2026-10-13T05:22:09","date_gmt":"2026-10-13T05:22:09","guid":{"rendered":"https:\/\/www.newsbeep.com\/us\/880494\/"},"modified":"2026-10-13T05:22:09","modified_gmt":"2026-10-13T05:22:09","slug":"the-untapped-promise-of-genetics-in-multiple-sclerosis-neurologylive","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/us\/880494\/","title":{"rendered":"The Untapped Promise of Genetics in Multiple Sclerosis | NeurologyLive"},"content":{"rendered":"\n<p class=\"\">In episode 4, the panel turns to genetics and pharmacogenomics. McGinley admits that outside of label-required steps such as CYP2C9 genotyping before starting siponimod, pharmacogenetic data play little role in her daily practice. Cebull recalls a recent patient with a less common CYP2C9 variant that sent her team to the pharmacy and the manufacturer to sort out dosing. She notes that the experience underscored the need for genetically diverse clinical trial populations.<\/p>\n<p class=\"\">Bermel argues that the future likely lies not in a single gene but in multidimensional biological profiling that could predict disease course and guide treatment choices, such as whether a patient is better suited to a B-cell\u2013depleting therapy or a Bruton tyrosine kinase inhibitor. He contrasts MS, which is still classified by observed phenotype, with oncology, where a term like \u201ctriple-negative breast cancer\u201d immediately conveys biology and prognosis. Cebull adds that patients often ask about their children\u2019s risk, and reliable genetic predictors could one day help answer those questions.<\/p>\n","protected":false},"excerpt":{"rendered":"In episode 4, the panel turns to genetics and pharmacogenomics. McGinley admits that outside of label-required steps such&hellip;\n","protected":false},"author":2,"featured_media":880495,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[50],"tags":[200,79],"class_list":["post-880494","post","type-post","status-publish","format-standard","has-post-thumbnail","category-genetics","tag-genetics","tag-science"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/880494","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/comments?post=880494"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/880494\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media\/880495"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media?parent=880494"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/categories?post=880494"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/tags?post=880494"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}