{"id":883024,"date":"2026-10-15T09:50:12","date_gmt":"2026-10-15T09:50:12","guid":{"rendered":"https:\/\/www.newsbeep.com\/us\/883024\/"},"modified":"2026-10-15T09:50:12","modified_gmt":"2026-10-15T09:50:12","slug":"colossal-biosciences-announces-new-ai-platform-to-help-accelerate-de-extinction-efforts","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/us\/883024\/","title":{"rendered":"Colossal Biosciences announces new AI platform to help accelerate de-extinction efforts"},"content":{"rendered":"

Colossal Biosciences announced Wednesday <\/a>a new AI platform to help accelerate its efforts to bring back extinct species, TechCrunch can exclusively report.\u00a0<\/p>\n

The platform, called GenoMorph, uses advanced 3D morphology, comparative genomics, and developmental biology to identify genes that could be edited in de-extinction projects with limited gene data. The company is using it as part of its effort to bring back the dodo bird, for which there are limited genomes to work with.\u00a0<\/p>\n

For example, the company is working with only one dodo genome compared to the 100 genomes it has been able to obtain as part of its woolly mammoth de-extinction project. DNA from the woolly mammoth is more plentiful because the colder climates the animal lived in preserve the DNA better than the tropics where the dodo lived, the company said.<\/p>\n

\u201cNormally, scientists can compare many genomes to understand which genetic differences are responsible for certain traits,\u201d Colossal CEO and co-founder Ben Lamm told TechCrunch. \u201cWe don\u2019t have that luxury with ancient DNA from extinct species whose DNA is severely limited, and we can only get a small number of complete genomes.\u201d\u00a0<\/p>\n

To build GenoMorph, Lamm said the company collected a bunch of developmental data from \u201cchickens, quail, ducks, and pigeons,\u201d and combined it with the \u201cgenetic information and 3D skull measurements from more than 70 bird species.\u201d He said it took more than a year of work to build this platform, which also builds on the company\u2019s years of work in de-extinction.\u00a0<\/p>\n

\u201cThe AI learns which regions of DNA are active as different birds develop their beaks and facial structures, and uses that information to predict which genetic switches may have given the dodo its iconic appearance.\u201d He said to think of the platform as a \u201ctreasure map for the dodo genome,\u201d where, rather than searching through a bunch of potential genetic differences, GenoMorph can help the Colossal team find only the genetic differences that matter.\u00a0<\/p>\n

\"\"Image Credits:Colossal Labs<\/p>\n

\u201cSo far we\u2019ve identified approximately 2,300 promising DNA editing targets for the dodo cranial facial morphology that we can now test in the lab,\u201d he continued. He said GenoMorph will help the company tackle one of its biggest bottlenecks in trying to de-extinct animals \u2014 finding out which changes actually make an extinct species unique. But Lamm said scientists also need to test whether those edits can create the physical traits they need.\u00a0<\/p>\n

\u201cWe\u2019ve developed a new system that uses lipid nanoparticles to deliver gene-editing tools directly into developing bird embryos,\u201d he said. This will help the team see how certain genetic changes impact the development of a bird \u201cwithout having to wait through an entire breeding cycle that requires\u00a0birds to reach sexual maturity.\u201d\u00a0<\/p>\n

The company also announced Wednesday that its Nicobar pigeon colony now has 36 birds and that it has successfully created the essential cells that become eggs and sperm. <\/p>\n

\u201cBecause the Nicobar pigeon is the dodo\u2019s closest living relative, those cells are a critical part of our strategy for creating birds that carry dodo traits,\u201d he said.\u00a0Next, the company is hoping to prove what GenoMorph predicts in a lab. \u201cWhat\u2019s most exciting is that we\u2019re reaching a point where the different technologies we\u2019ve been developing are starting to converge together and help other projects we are working on in a completely different part of the tree of life,\u201d Lamm continued.\u00a0<\/p>\n

When asked whether it was safe to edit genes this way, Lamm said the point of developing a technology like GenoMorph is to make genetic engineering \u201cmore precise, controlled, and testable.\u201d He said the product doesn\u2019t edit genes itself, but helps their team identify which genetic changes are worth investigating.\u00a0<\/p>\n

\u201cIdentifying a potential edit doesn\u2019t mean we immediately introduce it into an animal or assume it\u2019s safe,\u201d he continued. \u201cThe more precisely we can identify and validate these changes, the more informed our decisions become throughout the process.\u201d\u00a0<\/p>\n

Meanwhile, Colossal Biosciences\u2019 latest technology has already obtained a vote of confidence from XPRIZE founder Peter Diamandis. Diamandis, who is an investor in Colossal, announced<\/a> on Wednesday that he has founded a new VC firm, NeoGenesis Capital,<\/a> to back companies using Colossal Biosciences\u2019 programmable biology platform across health, agriculture, and conservation.<\/p>\n

When you purchase through links in our articles, we may earn a small commission<\/a>. This doesn\u2019t affect our editorial independence.<\/p>\n","protected":false},"excerpt":{"rendered":"Colossal Biosciences announced Wednesday a new AI platform to help accelerate its efforts to bring back extinct species,…\n","protected":false},"author":2,"featured_media":883025,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[32],"tags":[182,55602,79],"class_list":["post-883024","post","type-post","status-publish","format-standard","has-post-thumbnail","category-science","tag-ai","tag-colossal-biosciences","tag-science"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/883024","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/comments?post=883024"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/883024\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media\/883025"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media?parent=883024"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/categories?post=883024"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/tags?post=883024"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}