An Upstate South Carolina city continues to hold the title of “rattiest city” in the state and sits among the top 50 rat-infested cities in the U.S.<\/p>\n
Greenville continues to hold a place in Orkin’s “Rattiest Cities” list in 2026, but it has dropped a number of spots since 2025.<\/a> Orkin assesses the “rattiest cities”<\/a> by tracking new rodent services in owner-occupied residences during 12 months between Aug. 9, 2025, and Aug. 9, 2026.<\/p>\n “There’s no single type of city or climate that’s immune to rodent pressure,” said Dr. Shannon Sked, National Technical Director at Orkin. “Rats and mice are highly adaptable and can thrive in communities across the country wherever they can find food, water and shelter.”<\/p>\n Here’s where Greenville ranks among the “rattiest cities” in the U.S. for 2026.<\/p>\n Where did Greenville rank in Orkin’s rattiest cities?<\/p>\n In 2026, Greenville landed at No. 40 of the most rat-infested cities in the U.S., a drop of 10 spots from 2025.<\/p>\n Greenville was the only South Carolina city to make the top 50.<\/p>\n What city has the most rats in the U.S.?<\/p>\n Los Angeles still holds the title of “rattiest city” for the second year in a row. The City of Angels out-ratted Chicago<\/a> in 2025, which held the top spot on Orkin’s list for a decade.<\/p>\n Orkin’s top 10 ‘Rattiest Cities’<\/p>\n Orkin found the “Rattiest Cities” in the U.S. Here’s the top 10.<\/p>\n Philadelphia, Pennsylvania<\/p>\n