Metaberine is a berberine extract from Berberis aristata, created by India-based ingredient developer Zeus Hygia Life Sciences using its proprietary BioSOLVE processing technology. It is distributed in North America by CK Nutraceuticals. <\/p>\n
In the randomized, double-blind, placebo-controlled crossover study, published in the International Journal of Clinical Trials<\/a>, fasting GLP-1 rose 29% and postprandial GLP-1 rose 22% with Metaberine, while placebo produced little change. <\/p>\n The 14-day trial reported a statistically significant difference in weight change between the two treatments: weight held roughly level with Metaberine but rose slightly with placebo, a gap of about 0.35 kg (under 1 lb). The 36 participants had a mean BMI of about 25.8. <\/p>\n However, Mouli Srikar Avileli, senior business development manager at Zeus Hygia, told NutraIngredients that the trial was not designed to establish weight-loss efficacy of the ingredient. <\/p>\n Beyond the GLP-1 findings, the trial reported reductions in glucose exposure and peak glucose, and modest favorable lipid changes, including lower LDL and higher HDL cholesterol. <\/p>\n Managing expectations <\/p>\n Berberine has developed a reputation as \u201cnature\u2019s Ozempic<\/a>,\u201d fueling consumer demand, and coinciding with a surge in sales<\/a>. Avileli said brands should avoid encouraging that comparison. <\/p>\n \u201cBrands should clearly distinguish support for the body\u2019s natural GLP-1 response from prescription GLP-1 receptor agonist medications,\u201d Avileli said. \u201cThese are not equivalent approaches, and consumers should not be led to expect comparable weight-loss results from a botanical supplement.\u201d <\/p>\n He said brands should focus on the glucose-metabolism benefits and endogenous GLP-1 response seen in the study, adding that weight-management claims \u201cshould be supported by appropriate clinical evidence rather than inferred solely from changes in GLP-1 levels.\u201d <\/p>\n Avileli added that GLP-1 plays a role in glucose regulation, insulin secretion and appetite signaling, and that the findings suggest Metaberine \u201cmay support metabolic health\u201d through the body\u2019s natural incretin response. <\/p>\n Next steps <\/p>\n Zeus Hygia says its processing improves berberine\u2019s solubility and absorption, allowing a daily dose of 200 mg rather than the 500 to 1,500 mg typical of standard extracts. <\/p>\n In a separate pharmacokinetic study, the company reports, a 200 mg dose of Metaberine reached a peak concentration 37 times that of a conventional berberine powder, within 30 minutes rather than eight hours, and was about nine times more bioavailable. <\/p>\n Avileli said the lower dose could allow smaller dosage forms and more flexible multi-ingredient formulas, and may simplify daily supplementation by reducing pill burden. However, longer-term comparative studies are needed to show whether it improves adherence or tolerability, he said. <\/p>\n Further than this, Avileli also confirmed that a second clinical study is underway, evaluating additional weight-management markers, including changes in BMI and waist circumference. <\/p>\n \u201cThe findings are expected to provide further insights into whether the metabolic benefits observed translate into measurable weight-management outcomes,\u201d he said. <\/p>\n","protected":false},"excerpt":{"rendered":"Metaberine is a berberine extract from Berberis aristata, created by India-based ingredient developer Zeus Hygia Life Sciences using…\n","protected":false},"author":2,"featured_media":904404,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[61],"tags":[378506,378507,378508,9070,19485,378509,277679,226297,378510,99910,378511,378512,69773,378513,173901,378514,378515,2854,97,9081,27087,378516,378517,29772,269,79224,378518,38782,378519,44489,378520,378521],"class_list":["post-904403","post","type-post","status-publish","format-standard","has-post-thumbnail","category-nutrition","tag-allocryptopine","tag-argemone","tag-argemone-mexicana","tag-background","tag-beautiful","tag-bermuda-thistle","tag-bloom","tag-blooming","tag-blue-sky","tag-cardo","tag-cardosanto","tag-chelerythrine","tag-closeup","tag-coptisine","tag-flora","tag-floral","tag-flowering-thistle","tag-green","tag-health","tag-macro","tag-mexican","tag-mexican-prickly-poppy","tag-mexicana","tag-natural","tag-nutrition","tag-outdoor","tag-spiky-leaves","tag-spring","tag-thorny-plant","tag-wild","tag-wild-flower","tag-yellow-flower"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/904403","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/comments?post=904403"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/904403\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media\/904404"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media?parent=904403"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/categories?post=904403"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/tags?post=904403"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}