{"id":9096,"date":"2025-07-14T12:51:04","date_gmt":"2025-07-14T12:51:04","guid":{"rendered":"https:\/\/www.newsbeep.com\/us\/9096\/"},"modified":"2025-07-14T12:51:04","modified_gmt":"2025-07-14T12:51:04","slug":"unm-researchers-plan-clinical-trials-to-test-vaccine-against-alzheimers-promoting-tau-protein","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/us\/9096\/","title":{"rendered":"UNM Researchers Plan Clinical Trials to Test Vaccine Against Alzheimer\u2019s-Promoting Tau Protein"},"content":{"rendered":"

University of New Mexico Health Sciences researchers hope to launch human clinical trials in their quest for a vaccine to prevent the buildup of pathological tau \u2013 a protein in the brain associated with Alzheimer\u2019s dementia.<\/p>\n

In a new paper published in Alzheimer\u2019s and Dementia: The Journal of the Alzheimer\u2019s Association<\/a>, a team led by Kiran Bhaskar, PhD, professor in the Department of Molecular Genetics & Microbiology<\/a> in the UNM School of Medicine, found that the experimental vaccine generated a robust immune response in both mice and non-human primates, building on earlier research.<\/p>\n

\u201cBecause we\u2019ve shown efficacy in the non-human primate, I think that is suggesting to us it’s much closer to a clinical trial,\u201d Bhaskar said, adding that he and his colleagues are seeking funding from venture capitalists and the Alzheimer\u2019s Association to launch a Phase 1 trial in humans.<\/p>\n

Tau is a naturally occurring protein that helps stabilize neurons, but when it undergoes a process called phosphorylation, it deforms and is ejected from neurons into the extracellular space, creating the tangles that are characteristic of Alzheimer\u2019s and other neurodegenerative diseases.<\/p>\n

\"Tau<\/p>\n

\u00a0<\/p>\n

Because we\u2019ve shown efficacy in the non-human primate, I think that is suggesting to us it’s much closer to a clinical trial.<\/p>\n

\u00a0<\/p>\n

\u00a0-Kiran Bhaskar, PhD, Professor, Dept. of Molecular Genetics & Microbiology, UNM School of Medicine<\/p>\n

There are several new FDA-approved treatments for drugs that reduce levels of amyloid beta, another protein implicated in Alzheimer\u2019s pathology, but they have only a modest effect on the progression of the disease, leading many to wonder whether targeting tau might be a better bet.<\/p>\n

The active immunotherapy developed at UNM generates antibodies that bind to pT181, a region of the altered tau protein that has been identified as an Alzheimer\u2019s biomarker. In a 2019 paper published in NPJ Vaccines<\/a>, Bhaskar and his colleagues reported that when the vaccine was given to mice bred to express pathological tau they generated antibodies, reduced the extent of the tangles in key brain structures and improved their performance on tests to gauge their cognitive disability.<\/p>\n

The new paper expands on those findings. The vaccine elicited a strong immune response in two other strains of mice bred to develop tau-related disease \u2013 one of which had a human tau gene inserted in its genome. In a collaboration with the University of California, Davis, and the California National Primate Research Center\u00a0<\/a> the vaccine was also administered to macaques, primates whose immune systems and brains are closer to humans. They also showed a strong and durable immune response.<\/p>\n

The researchers also tested antibodies in the serum from the immunized monkeys on samples of blood plasma drawn from people with mild cognitive impairment, often a precursor to full-blown Alzheimer\u2019s dementia, as well as the sera in brain tissue from people who had died from Alzheimer\u2019s, and found that they bound to the human version of the tau protein.<\/p>\n

\"TAU<\/p>\n

Kiran Bhaskar, PhD, center, and Bryce Chackerian, PhD, right, walking on UNM North Campus with Janice Knoefel, MD, a UNM neurologist and geriatrician who was instrumental in recruiting patients for the study. Photo Credit: Allan Stone<\/p>\n

The vaccine was developed using a virus-like particle (VLP) platform developed by Bryce Chackerian, PhD, and David Peabody, PhD, Bhaskar\u2019s colleagues in Molecular Genetics & Microbiology. VLPs are essentially viruses whose DNA has been removed, rendering them harmless. Snippets of proteins \u2013 in this case pT181 \u2013 can be attached to their surface, rendering them visible to immune cells on the lookout for invaders.<\/p>\n

VLP-based vaccines have been shown to create durable immunity, with one primary inoculation and two booster shots, Bhaskar said. They don\u2019t require adjuvants \u2013 substances (such as aluminum) administered with a vaccine to enhance the immune response. And, they have been shown to be safe in humans.<\/p>\n

Nicole Maphis, PhD, a postdoctoral researcher in the UNM Department of Neurosciences, was the first author on both of the vaccine papers. She said the collaboration with UC Davis was critical for validating the vaccine\u2019s efficacy.<\/p>\n

\u201cThis was important because it extends our work in an animal model that is more similar to humans,\u201d she said. \u201cMice don’t have a human immune response, but these non-human primates, their immune response is much more similar to humans.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"University of New Mexico Health Sciences researchers hope to launch human clinical trials in their quest for a…\n","protected":false},"author":2,"featured_media":9097,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[50],"tags":[200,79],"class_list":["post-9096","post","type-post","status-publish","format-standard","has-post-thumbnail","category-genetics","tag-genetics","tag-science"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/9096","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/comments?post=9096"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/9096\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media\/9097"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media?parent=9096"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/categories?post=9096"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/tags?post=9096"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}