Fagarasan, S. Evolution, development, mechanism and function of IgA in the gut. Curr. Opin. Immunol. 20, 170\u2013177 (2008).<\/p>\n
Article<\/a>\u00a0 Pabst, O. & Slack, E. IgA and the intestinal microbiota: the importance of being specific. Mucosal Immunol. 13, 12\u201321 (2020).<\/p>\n Article<\/a>\u00a0 Huus, K. E., Petersen, C. & Finlay, B. B. Diversity and dynamism of IgA\u2212microbiota interactions. Nat. Rev. Immunol. 21, 514\u2013525 https:\/\/doi.org\/10.1038\/s41577-021-00506-1<\/a> (2021).<\/p>\n Article<\/a>\u00a0 Catanzaro, J. R. et al. IgA-deficient humans exhibit gut microbiota dysbiosis despite secretion of compensatory IgM. Sci. Rep. 9, 13574 (2019).<\/p>\n Article<\/a>\u00a0 Yel, L. Selective IgA deficiency. J. Clin. Immunol. 30, 10\u201316 https:\/\/doi.org\/10.1007\/s10875-009-9357-x<\/a> (2010).<\/p>\n Article<\/a>\u00a0 Fadlallah, J. et al. Microbial ecology perturbation in human IgA deficiency. Sci. Transl. Med. 10, eaan1217 (2018).<\/p>\n Article<\/a>\u00a0 Conrey, P. E. et al. IgA deficiency destabilizes homeostasis toward intestinal microbes and increases systemic immune dysregulation. Sci. Immunol. 8, eade2335 (2023).<\/p>\n Article<\/a>\u00a0 Moll, J. M. et al. Gut microbiota perturbation in IgA deficiency is influenced by IgA-autoantibody status. Gastroenterology 160, 2423\u20132434 https:\/\/doi.org\/10.1053\/j.gastro.2021.02.053<\/a> (2021).<\/p>\n Article<\/a>\u00a0 Shroff, K. E., Meslin, K. & Cebra, J. J. Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut. Infect. Immun. 63, 3904\u20133913 (1995).<\/p>\n Article<\/a>\u00a0 Singh, K., Chang, C. & Gershwin, M. E. IgA deficiency and autoimmunity. Autoimmun. Rev. 13, 163\u2013177 (2014).<\/p>\n Article<\/a>\u00a0 Ludvigsson, J. F., Neovius, M., Ye, W. & Hammarstr\u00f6m, L. IgA deficiency and risk of cancer: a population-based matched cohort study. J. Clin. Immunol. 35, 182\u2013188 (2015).<\/p>\n Article<\/a>\u00a0 Langford, T. D. et al. Central importance of immunoglobulin A in host defense against Giardia spp. Infect. Immun. 70, 11\u201318 (2002).<\/p>\n Article<\/a>\u00a0 Blutt, S. E., Miller, A. D., Salmon, S. L., Metzger, D. W. & Conner, M. E. IgA is important for clearance and critical for protection from rotavirus infection. Mucosal Immunol. 5, 712\u2013719 (2012).<\/p>\n Article<\/a>\u00a0 Moor, K. et al. High-avidity IgA protects the intestine by enchaining growing bacteria. Nature 544, 498\u2013502 (2017).<\/p>\n Article<\/a>\u00a0 J\u00f8rgensen, S. F. et al. Selective IgA deficiency in humans is associated with reduced gut microbial diversity. J. Allergy Clin. Immunol. 143, 1969\u20131971(2019).<\/p>\n Article<\/a>\u00a0 Gatti, R. A. & Good, R. A. Occurrence of malignancy in immunodeficiency diseases: a literature review. Cancer 28, 89\u201398 (1971).<\/p>\n Article<\/a>\u00a0 Filipovich, A. H., Mathur, A., Kamat, D., Kersey, J. H. & Shapiro, R. S. Lymphoproliferative disorders and other tumors complicating immunodeficiencies. Immunodeficiency 5, 91\u2013112 (1994).<\/p>\n CAS<\/a>\u00a0 Ludvigsson, J. F., Neovius, M. & Hammarstr\u00f6m, L. IgA deficiency & mortality: a population-based cohort study. J. Clin. Immunol. 33, 1317\u20131324 (2013).<\/p>\n Article<\/a>\u00a0 Cunningham-Rundles, C., Pudifin, D. J., Armstrong, D. & Good, R. A. Selective IgA deficiency and neoplasia. Vox Sang. 38, 61\u201367 (1980).<\/p>\n CAS<\/a>\u00a0 Pulvirenti, F. et al. Gastric cancer is the leading cause of death in Italian adult patients with common variable immunodeficiency. Front. Immunol. 9, 2546 (2018).<\/p>\n Article<\/a>\u00a0 Shulzhenko, N. et al. Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut. Nat. Med. 17, 1585\u20131593 (2011).<\/p>\n Article<\/a>\u00a0 Kawamoto, S. et al. The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut. Science 336, 485\u2013489 (2012).<\/p>\n Article<\/a>\u00a0 Kubinak, J. L. et al. MyD88 signaling in T cells directs IgA-mediated control of the microbiota to promote health. Cell Host Microbe 17, 153\u2013163 (2015).<\/p>\n Article<\/a>\u00a0 Suzuki, K. et al. Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut. Proc. Natl Acad. Sci. USA 101, 1981\u20131986 (2004).<\/p>\n Article<\/a>\u00a0 Fagarasan, S. et al. Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora. Science 298, 1424\u20131427 (2002).<\/p>\n Article<\/a>\u00a0 Gopalakrishna, K. P. et al. Maternal IgA protects against the development of necrotizing enterocolitis in preterm infants. Nat. Med. 25, 1110\u20131115 (2019).<\/p>\n Article<\/a>\u00a0 Kawamoto, S. et al. Foxp3+ T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis. Immunity 41, 152\u2013165 (2014).<\/p>\n Article<\/a>\u00a0 Nagashima, K. et al. Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota. Nat. Immunol. 18, 675\u2013682 (2017).<\/p>\n Article<\/a>\u00a0 Peterson, D. A. et al. Characterizing the interactions between a naturally primed immunoglobulin A and its conserved Bacteroides thetaiotaomicron species-specific epitope in gnotobiotic mice. J. Biol. Chem. 290, 12630\u201312649 https:\/\/doi.org\/10.1074\/jbc.m114.633800<\/a> (2015).<\/p>\n Article<\/a>\u00a0 Nakajima, A. et al. IgA regulates the composition and metabolic function of gut microbiota by promoting symbiosis between bacteria. J. Exp. Med. 215, 2019\u20132034 (2018).<\/p>\n Article<\/a>\u00a0 Donaldson, G. P. et al. Gut microbiota utilize immunoglobulin A for mucosal colonization. Science 360, 795\u2013800 (2018).<\/p>\n Article<\/a>\u00a0 Rollenske, T. et al. Parallelism of intestinal secretory IgA shapes functional microbial fitness. Nature 598, 657\u2013661 https:\/\/doi.org\/10.1038\/s41586-021-03973-7<\/a> (2021).<\/p>\n Article<\/a>\u00a0 Harriman, G. R. et al. Targeted deletion of the IgA constant region in mice leads to IgA deficiency with alterations in expression of other Ig isotypes. J. Immunol. 162, 2521\u20132529 (1999).<\/p>\n Article<\/a>\u00a0 Murthy, A. K., Dubose, C. N., Banas, J. A., Coalson, J. J. & Arulanandam, B. P. Contribution of polymeric immunoglobulin receptor to regulation of intestinal inflammation in dextran sulfate sodium-induced colitis. J. Gastroenterol. Hepatol. 21, 1372\u20131380 (2006).<\/p>\n Article<\/a>\u00a0 Mathias, A. & Corth\u00e9sy, B. N-Glycans on secretory component: mediators of the interaction between secretory IgA and gram-positive commensals sustaining intestinal homeostasis. Gut Microbes 2, 287\u2013293 (2011).<\/p>\n Article<\/a>\u00a0 Kaetzel, C. S. The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces. Immunol. Rev. 206, 83\u201399 (2005).<\/p>\n Article<\/a>\u00a0 Ramanan, D. et al. An immunologic mode of multigenerational transmission governs a gut Treg setpoint. Cell 181, 1276\u20131290 (2020).<\/p>\n Article<\/a>\u00a0 van der Post, S., Birchenough, G. M. H. & Held, J. M. NOX1-dependent redox signaling potentiates colonic stem cell proliferation to adapt to the intestinal microbiota by linking EGFR and TLR activation. Cell Rep. 35, 108949 (2021).<\/p>\n Article<\/a>\u00a0 Grivennikov, S. I. et al. Adenoma-linked barrier defects and microbial products drive IL-23\/IL-17-mediated tumour growth. Nature 491, 254\u2013258 (2012).<\/p>\n Article<\/a>\u00a0 Ansari, Y. S. E. et al. T follicular helper cell expansion and hyperimmunoglobulinemia with spontaneous IgE production to dietary antigens in IgA-deficient mice. Mucosal Immunol. 18, 481\u2013490 (2025).<\/p>\n Article<\/a>\u00a0 Clay, S. L., Fonseca-Pereira, D. & Garrett, W. S. Colorectal cancer: the facts in the case of the microbiota. J. Clin. Invest. 132, e155101 (2022).<\/p>\n Article<\/a>\u00a0 Donaldson, G. P., Lee, S. M. & Mazmanian, S. K. Gut biogeography of the bacterial microbiota. Nat. Rev. Microbiol. 14, 20\u201332 (2015).<\/p>\n Article<\/a>\u00a0 Beumer, J. & Clevers, H. Cell fate specification and differentiation in the adult mammalian intestine. Nat. Rev. Mol. Cell Biol. 22, 39\u201353 (2021).<\/p>\n Article<\/a>\u00a0 Tsang, D. K. L. et al. A single cell survey of the microbial impacts on the mouse small intestinal epithelium. Gut Microbes 14, 2108281 (2022).<\/p>\n Article<\/a>\u00a0 Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S. & Medzhitov, R. Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis. Cell 118, 229\u2013241 (2004).<\/p>\n Article<\/a>\u00a0 Rundegren, J. & Arnold, R. R. Differentiation and interaction of secretory immunoglobulin A and a calcium-dependent parotid agglutinin for several bacterial strains. Infect. Immun. 55, 288\u2013292 (1987).<\/p>\n Article<\/a>\u00a0 Mollenhauer, J. et al. The genomic structure of the DMBT1gene: evidence for a region with susceptibility to genomic instability. Oncogene 18, 6233\u20136240 (1999).<\/p>\n Article<\/a>\u00a0 Uhl\u00e9n, M. et al. Tissue-based map of the human proteome. Science 347, 1260419 (2015).<\/p>\n Article<\/a>\u00a0 Madsen, J. et al. CRP-ductin, the mouse homologue of gp-340\/deleted in malignant brain tumors 1 (DMBT1), binds gram-positive and gram-negative bacteria and interacts with lung surfactant protein D. Eur. J. Immunol. 33, 2327\u20132336 (2003).<\/p>\n Article<\/a>\u00a0 Reichhardt, M. P. et al. The salivary scavenger and agglutinin in early life: diverse roles in amniotic fluid and in the infant intestine. J. Immunol. 193, 5240\u20135248 (2014).<\/p>\n Article<\/a>\u00a0 Hopkins, E. G. D., Roumeliotis, T. I., Mullineaux-Sanders, C., Choudhary, J. S. & Frankel, G. Intestinal epithelial cells and the microbiome undergo swift reprogramming at the inception of colonic Citrobacter rodentium infection. mBio 10, e00062-19 (2019).<\/p>\n Article<\/a>\u00a0 M\u00fcller, H., Nagel, C., Weiss, C., Mollenhauer, J. & Poeschl, J. Deleted in malignant brain tumors 1 (DMBT1) elicits increased VEGF and decreased IL-6 production in type II lung epithelial cells. BMC Pulm. Med. 15, 32 (2015).<\/p>\n Article<\/a>\u00a0 Fre, S. et al. Notch signals control the fate of immature progenitor cells in the intestine. Nature 435, 964\u2013968 (2005).<\/p>\n Article<\/a>\u00a0 van Es, J. H. et al. Notch\/\u03b3-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 435, 959\u2013963 (2005).<\/p>\n Article<\/a>\u00a0 The Tabula Muris Consortium. Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris. Nature 562, 367\u2013372 (2018).<\/p>\n Article<\/a>\u00a0 The Tabula Sapiens Consortium. The Tabula Sapiens: a multiple-organ, single-cell transcriptomic atlas of humans. Science 376, eabl4896 (2022).<\/p>\n Article<\/a>\u00a0 Kabatnik, S. et al. Spatial characterization and stratification of colorectal adenomas by deep visual proteomics. iScience 27, 110620 (2024).<\/p>\n Article<\/a>\u00a0 Tang, Y. et al. MZB1-mediated IgA secretion suppresses the development and progression of colorectal cancer triggered by gut inflammation. Mucosal Immunol. 17, 450\u2013460 https:\/\/doi.org\/10.1016\/j.mucimm.2023.12.002<\/a> (2024).<\/p>\n Article<\/a>\u00a0 Biswas, S. et al. IgA transcytosis and antigen recognition govern ovarian cancer immunity. Nature 591, 464\u2013470 (2021).<\/p>\n Article<\/a>\u00a0 Pelka, K. et al. Spatially organized multicellular immune hubs in human colorectal cancer. Cell 184, 4734\u20134752 (2021).<\/p>\n Article<\/a>\u00a0 Dogan, I. et al. Multiple layers of B cell memory with different effector functions. Nat. Immunol. 10, 1292\u20131299 (2009).<\/p>\n Article<\/a>\u00a0 Robertson, S. J. et al. Comparison of co-housing and littermate methods for microbiota standardization in mouse models. Cell Rep. 27, 1910\u20131919 (2019).<\/p>\n Article<\/a>\u00a0 Quadros, R. M. et al. Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins. Genome Biol. 18, 92 (2017).<\/p>\n Article<\/a>\u00a0 Dmitrieva-Posocco, O. et al. \u03b2-Hydroxybutyrate suppresses colorectal cancer. Nature 605, 160\u2013165 (2022).<\/p>\n Article<\/a>\u00a0 Brugiroux, S. et al. Genome-guided design of a defined mouse microbiota that confers colonization resistance against Salmonella enterica serovar Typhimurium. Nat. Microbiol. 2, 16215 (2016).<\/p>\n Article<\/a>\u00a0 Mandal, S. et al. Analysis of composition of microbiomes: a novel method for studying microbial composition. Microb. Ecol. Health Dis. 26, 27663 (2015).<\/p>\n PubMed<\/a>\u00a0 Earley, Z. M. et al. GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology. Immunity 56, 43\u201357 (2023).<\/p>\n Article<\/a>\u00a0 Bharathkar, S. K. et al. The structures of secretory and dimeric immunoglobulin A. eLife 9, e56098 (2020).<\/p>\n Article<\/a>\u00a0 Dreyfus, C. et al. Highly Conserved Protective Epitopes on Influenza B Viruses. Science 337, 1343\u20131348 (2012).<\/p>\n Article<\/a>\u00a0 Miyoshi, H. & Stappenbeck, T. S. In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture. Nat. Protoc. 8, 2471\u20132482 (2013).<\/p>\n Article<\/a>\u00a0 Sanjana, N. E., Shalem, O. & Zhang, F. Improved vectors and genome-wide libraries for CRISPR screening. Nat. Methods 11, 783\u2013784 (2014).<\/p>\n Article<\/a>\u00a0 Roper, J. et al. In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Nat. Biotechnol. 35, 569\u2013576 (2017).<\/p>\n Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n","protected":false},"excerpt":{"rendered":"Fagarasan, S. Evolution, development, mechanism and function of IgA in the gut. Curr. Opin. Immunol. 20, 170\u2013177 (2008).…\n","protected":false},"author":2,"featured_media":914246,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[89160,21874,97,1159,14377,381930,1160,79],"class_list":["post-914245","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-antibodies","tag-colorectal-cancer","tag-health","tag-humanities-and-social-sciences","tag-microbiome","tag-mucosal-immunology","tag-multidisciplinary","tag-science"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/914245","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/comments?post=914245"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/posts\/914245\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media\/914246"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/media?parent=914245"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/categories?post=914245"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us\/wp-json\/wp\/v2\/tags?post=914245"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}