Analysis of individual patient pathway coordination in a cross-species single-cell kidney atlas
GBD Chronic Kidney Disease Collaboration Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis…
Digital twins and Big AI: the future of truly individualised healthcare
Foundational Research Gaps and Future Directions for Digital Twins | National Academies. https://www.nationalacademies.org/our-work/foundational-research-gaps-and-future-directions-for-digital-twins. Coveney, P. V. & Highfield…
Predicting resistance to chemotherapy using chromosomal instability signatures
CIN signatures as biomarkers of chemotherapy resistance The presence of CIN in a tumor has long been recognized…
Rapid deployment of large language model DeepSeek in Chinese hospitals demands a regulatory response
Gibney, E. Nature 638, 13–14 (2025). CAS PubMed Google Scholar DeepSeek-AI et al. Preprint at http://arxiv.org/abs/2501.12948 (2025). Thirunavukarasu,…
Pangenome analysis provides insights into legume evolution and breeding
Foyer, C. H. et al. Neglecting legumes has compromised human health and sustainable food production. Nat. Plants 2,…
Methods and applications of in vivo CRISPR screening
Auton, A. et al. A global reference for human genetic variation. Nature 526, 68–74 (2015). Google Scholar GarcÃa-GarcÃa,…
Towards improved fine-mapping of candidate causal variants
Visscher, P. M. et al. 10 years of GWAS discovery: biology, function, and translation. Am. J. Hum. Genet.…
A consensus statement on the use of digital twins in medicine
The DT is a generic instrument able to integrate different technologies applicable across the disease (and indeed health)…
Healthy lifestyle factors and recurrent cardiovascular events in patients with OSA: the SAVE study | BMC Medicine
Yeghiazarians Y, Jneid H, Tietjens JR, Redline S, Brown DL, El-Sherif N, et al. Obstructive sleep apnea and…
Large-scale genome-wide analyses of stuttering
Yairi, E. & Ambrose, N. Epidemiology of stuttering: 21st century advances. J. Fluen. Disord. 38, 66–87 (2013). Google…
Genetic variation in the activity of a TREM2–p53 signaling axis determines oxygen-induced lung injury
Pryhuber, G. S. et al. Prematurity and respiratory outcomes program (PROP): study protocol of a prospective multicenter study…
Single-cell polygenic risk scores dissect cellular and molecular heterogeneity of complex human diseases
Single-cell multiome dataset Single-cell multiome (snRNA-seq + snATAC-seq) data of the human left ventricle and lung were processed and clustered…