‘Game-changing’ cancer vaccine trial to begin on NHS
Patients in England with head and neck cancer will be fast-tracked onto a clinical trial for a “potentially…
Analysis of individual patient pathway coordination in a cross-species single-cell kidney atlas
GBD Chronic Kidney Disease Collaboration Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis…
A single genetic mutation may have made humans more vulnerable to cancer than chimpanzees
(SACRAMENTO) New research from UC Davis Comprehensive Cancer Center has uncovered an evolutionary change that may explain why…
Predicting resistance to chemotherapy using chromosomal instability signatures
CIN signatures as biomarkers of chemotherapy resistance The presence of CIN in a tumor has long been recognized…
Rapid deployment of large language model DeepSeek in Chinese hospitals demands a regulatory response
Gibney, E. Nature 638, 13–14 (2025). CAS PubMed Google Scholar DeepSeek-AI et al. Preprint at http://arxiv.org/abs/2501.12948 (2025). Thirunavukarasu,…
Pangenome analysis provides insights into legume evolution and breeding
Foyer, C. H. et al. Neglecting legumes has compromised human health and sustainable food production. Nat. Plants 2,…
Methods and applications of in vivo CRISPR screening
Auton, A. et al. A global reference for human genetic variation. Nature 526, 68–74 (2015). Google Scholar GarcÃa-GarcÃa,…
Towards improved fine-mapping of candidate causal variants
Visscher, P. M. et al. 10 years of GWAS discovery: biology, function, and translation. Am. J. Hum. Genet.…
Large-scale genome-wide analyses of stuttering
Yairi, E. & Ambrose, N. Epidemiology of stuttering: 21st century advances. J. Fluen. Disord. 38, 66–87 (2013). Google…
Detecting and quantifying clonal selection in somatic stem cells
Ethical approval Patient samples were collected with informed consent under the Mechanisms of Age-Related Clonal Haematopoiesis (MARCH) Study.…
Experimental evolution in an era of molecular manipulation
Monod, J. Chance and Necessity: an Essay on the Natural Philosophy of Modern Biology (Vintage Books, 1972). Blount,…
Incorporating genetic data improves target trial emulations and informs the use of polygenic scores in randomized controlled trial design
Ethics statement This study complies with all relevant ethical regulations and was conducted in accordance with the research…