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Browsing Tag

dna

156 posts
HHealth
New therapeutic approach targets undruggable protein driving aggressive breast cancer
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Study reveals a therapeutic vulnerability in aggressive subtype of triple-negative breast cancer

  • December 27, 2025
Dec 26 2025 A new study published today in Science Translational Medicine by researchers at The University of…
WWildlife
Polar Bears Are on The Brink of Extinction, But Their DNA May Be Fighting Back
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Polar Bears Are on The Brink of Extinction, But Their DNA May Be Fighting Back

  • December 23, 2025
As the Arctic warms and sea ice disappears, polar bears are being pushed into conditions they have never…
SScience
New insights reveal persistent genome structure during cell division
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Opposing protein forces fine tune mRNA stability in human cells

  • December 17, 2025
A newly revealed molecular tug-of-war may have implications for better understanding how a multitude of diseases and disorders…
MMental health
Why many mental health conditions may be more alike than we thought
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Why many mental health conditions may be more alike than we thought

  • December 16, 2025
Published on 16/12/2025 – 7:01 GMT+1 Different mental health conditions may have far more in common at a…
NNutrition
Study: Vitamin B12: A Comprehensive Review of Natural vs Synthetic Forms of Consumption and Supplementation. Image Credit: Fida Olga / Shutterstock
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Why the form of vitamin B12 you take may matter more than your intake

  • December 12, 2025
A new scientific review weighs natural and synthetic forms of vitamin B12, revealing where methylcobalamin may outperform standard…
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
HHealth
New approach doubles chemotherapy effectiveness by targeting cancer cell memory
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AI uncovers how DNA architecture failures trigger blood cancer

  • December 11, 2025
Cancer isn’t just about broken genes-it’s about broken architecture. Imagine a city where roads suddenly vanish, cutting off…
SScience
Study: Nanomaterial-induced mitochondrial biogenesis enhances intercellular mitochondrial transfer efficiency. Image Credit: Julien Tromeur / Shutterstock
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Nanoflower-treated stem cells deliver healthier mitochondria to stressed cells

  • December 10, 2025
By engineering nanomaterials that boost mitochondrial biogenesis, researchers show how stem cells can become powerful “mitochondrial biofactories,” offering…
TTechnology
Researchers unveil drug complex that makes cancer cells self-report to immune system
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A slow-growing, bone-covered, noncancerous mass named as ossifying spindled and epithelioid tumor

  • December 9, 2025
It’s not often that a pathologist gets to make a diagnosis that works for the patient by preventing…
HHealth
UCSF research maps over 600 conditions linked to endometriosis
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Modern pollutants and ancient genetic variants could explain why some women develop endometriosis

  • December 5, 2025
A new study suggests that certain genetic differences, passed down from ancient human ancestors, and exposure to common…
HHealth
New rapid PCR method detects Salmonella in food within hours
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New rapid PCR method detects Salmonella in food within hours

  • December 3, 2025
A new same-day detection strategy shows how simple, low-cost lab steps can uncover Salmonella in meats, vegetables, and…
HHealth
Epigenetic editing enables safer and more effective T cell therapies
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Epigenetic drift explains why the aging intestine becomes more vulnerable to cancer

  • November 29, 2025
Researchers from the Leibniz Institute on Aging – Fritz Lipmann Institute (FLI) in Jena, Germany, the Molecular Biotechnology…
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