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Browsing Tag

Drugs

227 posts
HHealth
Over-contracted gut muscles drive gastrointestinal symptoms in myotonic dystrophy
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Over-contracted gut muscles drive gastrointestinal symptoms in myotonic dystrophy

  • December 13, 2025
Myotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy, affecting about 1 in…
HHealth
Single antibody causes a rare but dangerous reaction to widely-used blood thinner
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Dinutuximab beta plus chemotherapy shrinks neuroblastoma tumors in children

  • December 13, 2025
Children with a rare form of cancer called neuroblastoma which hasn’t responded to initial treatment or that has…
HHealth
Excessive amounts of visceral fat tied to faster heart aging
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Human heart organoids enable new therapies for atrial fibrillation

  • December 13, 2025
Though an estimated 60 million people around the world have atrial fibrillation, or A-fib, a type of irregular…
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
MMedication
Traveling with meds? Brittney Griner shares the risks she learned
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Traveling with meds? Brittney Griner shares the risks she learned

  • December 12, 2025
Traveling with prescription medicine? Know the laws before you go Learn why checking prescription drug laws before traveling…
SScience
Uncovering the secrets of ‘SuperAgers’ and cognitive longevity
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New molecular ruler enables precise measurement of toxic Tau fibrils in fluid samples

  • December 12, 2025
Researchers have developed a new tool, FibrilPaint combined with the FibrilRuler test, that allows scientists to directly measure…
MMedication
Telangana DCA launches special enforcement drive to curb illegal sale of habit-forming drugs, abortion kits
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Telangana DCA launches special enforcement drive to curb illegal sale of habit-forming drugs, abortion kits

  • December 11, 2025
Hyderabad: Telangana Drugs Control Administration (DCA) on Wednesday launched a special enforcement drive to curb the illegal sale…
HHealth
Van Andel Institute and Cure Parkinson's extend major Parkinson's drug trial initiative
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Van Andel Institute and Cure Parkinson’s extend major Parkinson’s drug trial initiative

  • December 10, 2025
Van Andel Institute and Cure Parkinson’s have renewed a funding agreement to support the International Linked Clinical Trials…
MMedication
Daily Record
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NHS issues advice for Naproxen and aspirin users

  • December 10, 2025
The NHS has warned about the risk of side-effects from mixing with one common medicationFiona Callingham Lifestyle writer…
SScience
Study: Nanomaterial-induced mitochondrial biogenesis enhances intercellular mitochondrial transfer efficiency. Image Credit: Julien Tromeur / Shutterstock
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Nanoflower-treated stem cells deliver healthier mitochondria to stressed cells

  • December 10, 2025
By engineering nanomaterials that boost mitochondrial biogenesis, researchers show how stem cells can become powerful “mitochondrial biofactories,” offering…
NNutrition
Target stacking up on protein supplements while capitalizing on weight loss drug trend
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Target stacking up on protein supplements while capitalizing on weight loss drug trend

  • December 10, 2025
The rapid adoption of GLP-1 weight loss medications — drugs like Novo Nordisk’s Ozempic and Wegovy and Eli Lilly’s Zepbound…
HHealth
New targeted alpha therapy shows promise for patients with radioiodine-refractory thyroid cancer
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New targeted alpha therapy shows promise for patients with radioiodine-refractory thyroid cancer

  • December 5, 2025
A new targeted alpha therapy is showing promise for patients whose thyroid cancer no longer responds to radioactive…
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