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Browsing Tag

Inflammation

138 posts
HHealth
Excessive amounts of visceral fat tied to faster heart aging
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Human heart organoids enable new therapies for atrial fibrillation

  • December 13, 2025
Though an estimated 60 million people around the world have atrial fibrillation, or A-fib, a type of irregular…
HHealth
Excessive amounts of visceral fat tied to faster heart aging
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Nighttime heart attacks cause less damage due to neutrophil circadian rhythms

  • December 13, 2025
Heart attacks that occur at night are less severe than those that strike during the day. A new…
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
HHealth
Conceptual framework linking ultra-processed foods (UPFs) to mechanistic pathways, inflammatory cascade, clinical outcomes, and dietary interventions in inflammatory bowel disease (IBD).
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How ultra-processed foods shape Crohn’s disease risk and what dietary strategies can really help

  • December 12, 2025
New evidence reveals how everyday processed foods may disrupt gut barriers and amplify inflammation, while targeted dietary strategies…
HHealth
Study: Takeaway Food Consumption, Dietary Inflammatory Index, and Cardiometabolic Risk Factors in US Adults: Findings From NHANES (2009–2018). Image Credit: New Africa / Shutterstock
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What happens to your body when you eat takeaway food too often?

  • December 12, 2025
New evidence reveals how frequent takeaway meals elevate dietary inflammation and quietly reshape key metabolic risk factors, underscoring…
HHealthcare
BioAge shows promise with new drug BGE-102 in early trial
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BioAge shows promise with new drug BGE-102 in early trial

  • December 8, 2025
The company expands its Phase 1 trial after early signals show BGE-102’s potential to address inflammation beyond the…
HHealth
UCSF research maps over 600 conditions linked to endometriosis
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Modern pollutants and ancient genetic variants could explain why some women develop endometriosis

  • December 5, 2025
A new study suggests that certain genetic differences, passed down from ancient human ancestors, and exposure to common…
HHealth
Innovative VR therapy helps ease anxiety in cardiovascular disease
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Psychosocial stress in women linked to early signs of heart tissue changes

  • December 5, 2025
Women who report high levels of psychosocial stress, such as from caregiving and lack of emotional support, show…
HHealth
Middle precentral gyrus plays key role in orchestrating speech movements
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Understanding how adult brains adapt to challenge and change

  • December 4, 2025
In a revelatory Genomic Press Interview published today in Brain Medicine, Dr. Paul Lucassen, full professor at the…
HHealth
Microbial warning signs that predict death risk in severe pneumonia
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Microbial warning signs that predict death risk in severe pneumonia

  • December 3, 2025
Researchers uncover a microbial signature in the lungs of severe pneumonia patients. Could this help explain survival differences…
HHealth
New therapeutic approach targets undruggable protein driving aggressive breast cancer
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Obesity-driven estrone emerges as a key driver of deadly postmenopausal breast cancer

  • December 2, 2025
A new analysis of research into the most common type of breast cancer has zeroed in on an…
NNutrition
Pregnant woman on couch with man, both smiling and touching her belly.
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Early-life nutrition | National Institutes of Health (NIH)

  • December 2, 2025
Research in Context  November 25, 2025 Exposures in the womb can affect lifelong health Nutrition matters, and what young,…
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