Real-world, digital-first delivery of GLP-1 receptor agonist therapy in women
Study population Between 27 November 2024 and 31 January 2025, adult women (female sex at birth) were recruited…
Probing the many benefits of GLP-1 receptor agonists
RESEARCH HIGHLIGHT 05 October 2026 Glucagon-like peptide 1 (GLP-1) receptor agonists are approved for the treatment of type…
Associations of physical fitness with brain structure, pathology and cognition in cognitively normal older adults
Abrous, D. N. et al. Hallmarks of healthy cognitive aging: inter-individual differences in aging trajectories. Ageing Res. Rev.…
On-premise medical AI agents for reliable clinical decision-making
Ethics statement This study utilized deidentified, retrospective clinical data from the MIMIC-IV (version 2.2) and physician-curated cases from…
Initial lessons from real-world implementation of an AI-agent eye clinic in China
These authors contributed equally: Tao Yan, Di Zhang. Department of Automation, Tsinghua University, Beijing, China Tao Yan, Taizhangtian Ma, Chunyang…
Phenomic profiles and disease patterns of 1.9 million participants from Our Future Health
Ethical approval This study involves data from human participants that have participated in the OFH program and the…
A scoping review on the mental health harms of LLM-based chatbots
Weizenbaum, J. ELIZA—a computer program for the study of natural language communication between man and machine. Commun. ACM…
Psilocybin-assisted therapy for treatment-resistant major depressive disorder in a public healthcare setting: a randomized controlled trial
This study of psilocybin assisted-therapy for TRD—to our knowledge, the first RCT in this population to assess feasibility…
Divergent impacts of explainable AI for dermatological diagnosis on clinicians versus lay people
Study design We designed two complementary large-scale experiments to evaluate human−AI collaborative diagnostic performance across expertise levels (Fig.…
Learning from routine health system data builds better neuroimaging AI models
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This…
Integrated care pathway in individuals with Long COVID: STIMULATE-ICP, a cluster-randomized, phase 3 trial
Trial design and oversight The STIMULATE-ICP trial aimed to investigate the efficacy of an enhanced ICP for LC,…
Fixed-dose inotuzumab ozogamicin (INO) combined with Vincristine and Prednisone (VP) regimen as induction therapy for newly diagnosed B-cell acute lymphocytic leukemia (B-ALL): a multi-center, open-label, single-arm, prospective clinical study
Adult B-ALL exhibits significant heterogeneity and poor prognosis compared with the pediatric population. While the complete remission (CR)…