Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism
Alpaca immunization and VHH immune phage library biopanning Six alpacas were immunized subcutaneously with the ECD of hIL-10Rα,…
The cellular landscape of druggable RNA-binding proteins
Gerstberger, S., Hafner, M. & Tuschl, T. A census of human RNA-binding proteins. Nat. Rev. Genet. 15, 829–845…
Modular in vivo antibody–ADC click to reverse drug resistance in tumours
Ethical compliance Animal studies were performed at the Washington University School of Medicine in compliance with institutional guidelines…