Can a simple daily audio hypnosis session help women find relief from one of menopause’s most disruptive symptoms – hot flashes – without medication? A new clinical trial led by Baylor University’s Gary R. Elkins, Ph.D., professor of psychology and neuroscience and director of the Mind-Body Medicine Research Laboratory, suggests it can. By decreasing hot flash frequency and intensity by over 50%, self-guided hypnosis offers a nonhormonal option for the millions of women whose hot flashes interfere with sleep, mood and quality of life.

Published in the journal JAMA Network Open, the multicenter randomized clinical trial evaluated the effectiveness of a six-week, self-administered hypnosis program compared to a sham control using white noise. The study enrolled 250 postmenopausal women experiencing frequent hot flashes, including nearly 25% with a history of breast cancer – a group often excluded from hormone-based treatments.

It is estimated that over 25 million women in the United States have hot flashes, with up to 80% of women in the general population reporting hot flashes during the menopause transition, and 96% of women with breast cancer report hot flashes soon after beginning anti-cancer therapy. While hormone replacement therapy is highly effective in reducing hot flashes, it is not a safe choice for everyone, and therefore, women need additional safe and effective alternatives.”


Gary R. Elkins, Ph.D., professor of psychology and neuroscience, Baylor University

After six weeks of daily self-hypnosis audio recordings, participants reported a 53.4% reduction in both frequency and intensity of hot flashes, and at the 3-month follow-up, hot flashes were reduced by 60.9% compared to a 40.9% reduction for women in the control group. The guided self-hypnosis intervention had an even larger treatment effect on reducing hot flashes in women with a history of breast cancer (64% reduction after six weeks).

Self-guided hypnosis: A breakthrough approach

The study is the first to compare self-guided hypnosis with an active control condition (i.e. sham white noise control group), allowing researchers to better understand how much of the benefit came from people’s expectations or the placebo effect.

“This was a major breakthrough and innovation, as almost all prior studies of mind-body interventions have only used wait-list, psycho-education or simple relaxation to compare the active hypnotherapy intervention,” Elkins said. “Also, all sessions were self-administered hypnosis, which demonstrated that women could learn how to use hypnosis for hot flashes on their own with support and guidance.

Elkins emphasized that self-hypnosis provides benefits that are easily learned and practiced using audio recordings or app-delivered hypnotherapy.

“It can be practiced at home without needing to travel for doctor visits, and it is relatively inexpensive compared to in-person sessions,” Elkins said. “Once a person learns how to use self-hypnosis to reduce hot flashes and improve sleep, it can be used for other purposes such as managing anxiety, coping with pain and for stress management.”

At the 12-week follow-up, participants in the self-guided hypnosis group showed a 60.9% reduction in hot flashes as well as significantly greater improvements in sleep, mood, concentration and overall quality of life. Nearly 90% of participants in the hypnosis group reported feeling better, compared to 64% in the control group.

“We are very excited about the findings from this important study,” Elkins said. “Our ongoing research aims to further determine how self-hypnosis can significantly improve sleep for breast cancer survivors and women in the peri- to post-menopause transition.”

Through this and other studies, Elkins and his team have been able to determine that hypnotherapy is the only behavioral intervention consistently shown to reduce the frequency and severity of hot flashes to a clinically significant amount among both post-menopausal women and breast cancer survivors.

Source:

Journal reference:

Elkins, G., et al. (2025). Self-Administered Hypnosis vs Sham Hypnosis for Hot Flashes: A Randomized Clinical Trial. JAMA Network Open. doi: 10.1001/jamanetworkopen.2025.42537.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2841242