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Browsing Tag

Cytokines

12 posts
HHealth
Innate immune activation and microglial transition during neurodegeneration. (A) During neurodegeneration, distressed neurons release DAMPs such as mtDNA, ROS, HMGB1, aberrant proteins, and pTau–bound RNA. These signals activate resident microglia and astrocytes, which then recruit peripheral immune cells. As shown in more detail in B, activated microglia upregulate PRRs, including TLRs, RAGE, and cGAS, enabling detection of neuron-derived DAMPs. Engagement of PRRs induces proinflammatory gene expression programs and activates inflammasome pathways that promote release of chemokines and cytokines into the CNS parenchyma. As microglia transition from homeostatic to reactive states in a TREM2-dependent manner, damage-associated microglia increase MHC-II expression to support antigen presentation and coordination of adaptive immune responses that attempt to limit neurodegeneration.
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How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases

  • April 17, 2026
A sweeping review shows how the brain’s immune defenses can both fight and fuel neurodegeneration, revealing why timing,…
TTechnology
Study: Effect of Beetroot Nitrate Supplementation on Nitric Oxide Pathways and Oxy-Inflammatory Biomarkers in Amateur Triathletes: A Randomized Cross-Over Pilot Study. Image Credit: StockImageFactory.com / Shutterstock
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Beetroot supplement raises nitric oxide markers in triathletes after one week

  • April 14, 2026
A small pilot trial suggests a beetroot-based nitrate supplement can shift nitric oxide and redox pathways in amateur…
HHealth
Woman with cancer during chemotherapy walking around the hospital, aided my doctor
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Exercise cuts ‘chemo brain’ and fatigue in cancer patients

  • March 17, 2026
A simple home-based exercise plan helped patients stay active during chemotherapy, reducing mental fatigue and showing potential to…
HHealth
Bowls with tasty almonds on color background
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Can eating almonds reduce inflammation in obesity?

  • March 12, 2026
A six-week randomized trial shows that adding almonds to the daily diet of adults with obesity can improve…
HHealth
Scientists explore natural hypothermic states as therapy for brain injury
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Researchers identify immune markers linked to cognitive decline after viral infections

  • March 5, 2026
What impact does a viral infection have on our memory, attention, and concentration? The COVID-19 pandemic has reignited…
HHealth
Study: Immune modulation in response to coffee intake: a pilot study. Image Credit: ZeiMomArt / Shutterstock
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Study reveals coffee triggers distinct cytokine responses compared with pure caffeine

  • February 19, 2026
A controlled human study reveals that coffee’s complex chemical matrix may shape immune responses differently than pure caffeine,…
HHealth
NYU Langone strengthens world-leading GI cancer program with renowned leaders
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Chronic inflammation shapes cancer progression and immunotherapy response

  • February 16, 2026
Chronic inflammation is both a driver and suppressor of cancer depending on context. Key players-NF-κB, IL-6, STAT3, TAMs,…
HHealth
Study: Emerging Roles of Modern Lifestyle Factors in Microbiome Stability and Functionality. Image Credit: Kateryna Kon / Shutterstock
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How modern lifestyles reprogram the gut microbiome and shape disease risk

  • January 28, 2026
From jet lag and poor sleep to exercise and chronic stress, this review unpacks how everyday lifestyle factors…
HHealth
Exploring melatonin therapeutic potential in systemic lupus erythematosus
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Exploring melatonin therapeutic potential in systemic lupus erythematosus

  • December 13, 2025
A recent review published in Current Molecular Pharmacology explores the therapeutic potential of melatonin in systemic lupus erythematosus…
HHealth
Study: SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade. Image Credit: KwangSoo Kim / Shutterstock
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How COVID mRNA vaccines may make cancer treatments more effective

  • October 24, 2025
A new study reveals that SARS-CoV-2 mRNA vaccines can amplify immune checkpoint therapy in lung and skin cancers…
HHealth
NYU Langone strengthens world-leading GI cancer program with renowned leaders
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Visceral fat activity linked to advanced endometrial cancer

  • October 6, 2025
High metabolic activity of visceral fat may be associated with more aggressive endometrial cancer, new research presented today…
FFitness
Homemade Greek Yogurt in bowl
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Greek yogurt after exercise lowers inflammation more than carbs

  • September 28, 2025
Researchers discovered that young men who ate Greek yogurt after training showed lower levels of inflammation than those…
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